The activation of NF-κB and AP-1 in peripheral blood mononuclear cells isolated from patients with diabetic nephropathy

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

NF-κB: Ten Years After

1996 • 3,008 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

2002 • 2,164 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

2000 • 1,096 citations

Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications

2002 • 1,000 citations

Role of oxidative stress in development of complications in diabetes

1991 • 787 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Inhibitors of NF-κB signaling: 785 and counting

2006 • 553 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.

1994 • 527 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Reactive Oxygen Species-Regulated Signaling Pathways in Diabetic Nephropathy

2003 • 463 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Diabetic Vascular Complications: Pathophysiology, Biochemical Basis and Potential Therapeutic Strategy

2005 • 436 citations

AP-1: One Switch for Many Signals

1999 • 386 citations

Diabetes mellitus, hypertension, and cardiovascular disease: Which role for oxidative stress?

1995 • 367 citations

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

1992 • 353 citations

Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy

2006 • 352 citations

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

2000 • 327 citations

Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose

2000 • 312 citations

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.

1993 • 291 citations

Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule

1992 • 264 citations

Generation of reactive oxygen intermediates, activation of NF-κB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?

1999 • 213 citations

Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB

1999 • 190 citations

Evaluation of Urinary 8-Hydroxydeoxy-Guanosine as a Novel Biomarker of Macrovascular Complications in Type 2 Diabetes

2003 • 182 citations

Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B

1995 • 181 citations

The Dietary Pigment Curcumin Reduces Endothelial Tissue Factor Gene Expression by Inhibiting Binding of AP-1 to the DNA and Activation of NF-κB

1997 • 165 citations

Insufficient Glycemic Control Increases Nuclear Factor-κB Binding Activity in Peripheral Blood Mononuclear Cells Isolated From Patients With Type 1 Diabetes

1998 • 165 citations

PPARα activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats

2003 • 165 citations

AP-1 Proteins Mediate Hyperglycemia-Induced Activation of the Human TGF-β1 Promoter in Mesangial Cells

2000 • 162 citations

Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-κB in mononuclear cells

2004 • 155 citations

Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney

2005 • 140 citations

Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy

2005 • 112 citations

Study of urinary 8-hydroxydeoxyguanosine as a biomarker of oxidative DNA damage in diabetic nephropathy patients

2004 • 111 citations

The Renal Expression of Transforming Growth Factor-β Isoforms and Their Receptors in Acute and Chronic Experimental Diabetes in Rats*

2000 • 110 citations

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.

2000 • 102 citations

Role of oxidative stress in the development of diabetic nephropathy.

1995 • 87 citations

Cyclosporine a inhibits tissue factor expression in monocytes/macrophages

1996 • 71 citations

High glucose alone, as well as in combination with proinflammatory cytokines, stimulates nuclear factor kappa-B-mediated transcription in hepatocytes in vitro

2006 • 66 citations

Role of Cytokines, Tyrosine Kinase, and Protein Kinase C on Production of Superoxide and Induction of Scavenging Enzymes in Human Leukocytes

1996 • 63 citations

Does oxidant stress play a role in diabetic retinopathy?

1995 • 54 citations

Elevated Thrombomodulin Plasma Levels as a Result of Endothelial Involvement in Plasmodium falciparum Malaria

1994 • 49 citations

Role of Cytokines

2008 • 47 citations

Transforming growth factor-β₁differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells

2006 • 47 citations

Identification of monocytes in suspensions of mononuclear cells

1976 • 37 citations

Extracellular signals and intracellular pathways in diabetic nephropathy

2001 • 30 citations

Prevention of progression of renal fibrosis: how far are we?

1996 • 28 citations

The Renal Expression of Transforming Growth Factor- Isoforms and Their Receptors in Acute and Chronic Experimental Diabetes in Rats

2000 • 27 citations

Function and Activation of NF-kappa B in Immune System

2005 • 18 citations

Favorable Treatment Outcome with Neutralizing anti Transforming Growth Factor I:} Antibodies in Experimental Diabetic Kidney Disease

1999 • 4 citations