IL-17 Immunity in Human Type 1 Diabetes

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

2008 • 1,524 citations

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

2009 • 1,447 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

Late Developmental Plasticity in the T Helper 17 Lineage

2009 • 1,022 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

IL-21 and TGF-β are required for differentiation of human TH17 cells

2008 • 882 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

2009 • 774 citations

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

2008 • 715 citations

Identification of IL-17-producing FOXP3⁺regulatory T cells in humans

2009 • 657 citations

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

2009 • 545 citations

Heterogeneity of natural Foxp3 ⁺ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

2009 • 493 citations

Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives

2006 • 493 citations

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

2008 • 492 citations

Increased intestinal permeability precedes clinical onset of type 1 diabetes

2006 • 421 citations

Developmental plasticity of Th17 and Treg cells

2009 • 405 citations

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

2009 • 368 citations

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

2009 • 361 citations

Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells

2004 • 296 citations

Human memory FOXP3⁺Tregs secrete IL-17 ex vivo and constitutively express the T_H17 lineage-specific transcription factor RORγt

2009 • 293 citations

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

2009 • 279 citations

Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays

2001 • 231 citations

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

2008 • 191 citations

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

2008 • 182 citations

Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation

2009 • 169 citations

Immunologic Activity in the Small Intestinal Mucosa of Pediatric Patients With Type 1 Diabetes

2003 • 168 citations

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

2003 • 164 citations

Regulation of IL-17 in Human CCR6+ Effector Memory T Cells

2008 • 131 citations

Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis.

1998 • 117 citations

Involvement of β7 Integrin and Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) in the Development of Diabetes in Nonobese Diabetic Mice

1997 • 115 citations

Mucosa-Associated (βT-integrinhigh) Lymphocytes Accumulate Early in the Pancreas of NOD Mice and Show Aberrant Recirculation Behavior

1996 • 95 citations

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line

2009 • 90 citations

In Vitro–Deranged Intestinal Immune Response to Gliadin in Type 1 Diabetes

2004 • 90 citations

Interleukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells

2005 • 67 citations

Endothelial Cell-Binding Properties of Lymphocytes Infiltrated Into Human Diabetic Pancreas: Implications for Pathogenesis of IDDM

1993 • 56 citations

Protease-resistant human GAD-derived altered peptide ligands decrease TNF-α and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus

2009 • 19 citations