The Molecular Mechanisms Underlying the Regulation of the Biological Activity of Corticotropin-Releasing Hormone Receptors: Implications for Physiology and Pathophysiology

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

2002 • 1,241 citations

CRF and CRF Receptors: Role in Stress Responsivity and Other Behaviors

2004 • 1,235 citations

G Protein-coupled Receptors

1998 • 1,033 citations

Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse

2000 • 1,029 citations

Expression cloning of a human corticotropin-releasing-factor receptor.

1993 • 923 citations

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

1998 • 919 citations

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

2001 • 911 citations

A placental clock controlling the length of human pregnancy

1995 • 897 citations

Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development

1998 • 883 citations

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

2002 • 881 citations

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

2001 • 877 citations

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

2000 • 836 citations

Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

1995 • 836 citations

Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A

2004 • 745 citations

Roles of G‐protein‐coupled receptor dimerization

2004 • 668 citations

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

2001 • 647 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

The role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes

2000 • 618 citations

Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

2000 • 591 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

1996 • 561 citations

In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*

1982 • 557 citations

Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need

1995 • 525 citations

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

2002 • 519 citations

Desensitization of G-protein-coupled Receptors

1999 • 510 citations

Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.

1995 • 497 citations

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

2000 • 490 citations

Role of Corticotropin-Releasing Factor in Drug Addiction

2011 • 477 citations

CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.

1995 • 444 citations

Molecular Basis of Receptor/G-Protein-Coupling Selectivity

1998 • 444 citations

Endocrine Manifestations of Stimulatory G Protein α-Subunit Mutations and the Role of Genomic Imprinting

2001 • 420 citations

Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABA_AReceptor Subunits in Frontal Cortical Brain Region

2004 • 378 citations

A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle.

1995 • 373 citations

Heterotrimeric G proteins

1996 • 318 citations

Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor

2005 • 313 citations

The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.

1992 • 288 citations

Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes

2002 • 279 citations

Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways

2002 • 264 citations

Molecular Identification and Analysis of a Novel Human Corticotropin-Releasing Factor (CRF) Receptor: The CRF2γ Receptor

1998 • 258 citations

Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress

2002 • 255 citations

Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice.

1992 • 254 citations

Urocortin III-Immunoreactive Projections in Rat Brain: Partial Overlap with Sites of Type 2 Corticotrophin-Releasing Factor Receptor Expression

2002 • 240 citations

Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides

1995 • 239 citations

Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor.

1995 • 230 citations

Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

2001 • 222 citations

Corticotropin-Releasing Factor Receptors Couple to Multiple G-Proteins to Activate Diverse Intracellular Signaling Pathways in Mouse Hippocampus: Role in Neuronal Excitability and Associative Learning

2003 • 201 citations

NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor

2004 • 191 citations

The Origins of Diversity and Specificity in G Protein-Coupled Receptor Signaling

2005 • 188 citations

Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin.

1998 • 187 citations

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

1996 • 187 citations

Neuroendocrine Regulation of the Hypothalamic Pituitary Adrenal Axis by the nurr1/nur77 Subfamily of Nuclear Receptors

1997 • 185 citations

Responses of Plasma Adrenocorticotropin, Cortisol, and Dehydroepiandrosterone to Ovine Corticotropin- Releasing Hormone in Healthy Aging Men*

1986 • 183 citations

Activation of G-protein-coupled receptors: a common molecular mechanism

2003 • 182 citations

Alternative splicing of CRH‐R1 receptors in human and mouse skin: identification of new variants and their differential expression

2001 • 179 citations

Central CRF, urocortins and stress increase colonic transit via CRF₁ receptors while activation of CRF₂ receptors delays gastric transit in mice

2004 • 177 citations

Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): Development of CRFR2β-selective antisauvagine-30

1998 • 170 citations

Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus RecordedIn Vitro

2004 • 165 citations

Corticotropin-Releasing Hormone Augments Proinflammatory Cytokine Production from Macrophages In Vitro and in Lipopolysaccharide-Induced Endotoxin Shock in Mice

2002 • 162 citations

Nitric oxide NO - biogeneration regulation and relevence to human diseases

2003 • 162 citations

Potent and Long-Acting Corticotropin Releasing Factor (CRF) Receptor 2 Selective Peptide Competitive Antagonists

2002 • 157 citations

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice

1999 • 151 citations

The neurobiology of urocortin

2000 • 147 citations

Role of corticotropin-releasing hormone in onset of labour

1999 • 147 citations

Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: involvement of the nitric oxide-cyclic guanosine 3',5'-monophosphate-mediated pathway.

1995 • 145 citations

Expression of Urocortin and Corticotropin-Releasing Factor Receptor Subtypes in the Human Heart

2002 • 140 citations

Rat cerebral cortex corticotropin‐releasing hormone receptors: evidence for receptor coupling to multiple G‐proteins

2001 • 139 citations

Urocortin, But Not Urocortin II, Protects Cultured Hippocampal Neurons from Oxidative and Excitotoxic Cell Death via Corticotropin-Releasing Hormone Receptor Type I

2002 • 135 citations

Urocortin-II and Urocortin-III Are Cardioprotective against Ischemia Reperfusion Injury: An Essential Endogenous Cardioprotective Role for Corticotropin Releasing Factor Receptor Type 2 in the Murine Heart

2003 • 135 citations

Ligand requirements of the human corticotropin-releasing factor-binding protein.

1995 • 133 citations

Receptor-Mediated Adenylyl Cyclase Activation Through XLαs, the Extra-Large Variant of the Stimulatory G Protein α-Subunit

2002 • 129 citations

The cardiovascular physiologic actions of urocortin II: Acute effects in murine heart failure

2004 • 126 citations

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

2001 • 124 citations

Urocortin, but Not Corticotropin-Releasing Hormone (CRH), Activates the Mitogen-Activated Protein Kinase Signal Transduction Pathway in Human Pregnant Myometrium: An Effect Mediated via R1α and R2β CRH Receptor Subtypes and Stimulation of Gq-Proteins

2000 • 117 citations

A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor

1997 • 116 citations

Peripheral corticotropin-releasing hormone and urocortin in the control of the immune response

2001 • 116 citations

A Novel Spliced Variant of the Type 1 Corticotropin-Releasing Hormone Receptor with a Deletion in the Seventh Transmembrane Domain Present in the Human Pregnant Term Myometrium and Fetal Membranes

1999 • 116 citations

The N-Terminal Fragment of Human Parathyroid Hormone Receptor 1 Constitutes a Hormone Binding Domain and Reveals a Distinct Disulfide Pattern

2000 • 111 citations

Characterization of the Extra-large G Protein α-Subunit XLαs

2000 • 111 citations

Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF.

1996 • 110 citations

Protein Kinase A Mediates the Modulation of the Slow Ca²⁺-Dependent K⁺Current,I_sAHP, by the Neuropeptides CRF, VIP, and CGRP in Hippocampal Pyramidal Neurons

2000 • 110 citations

Corticotropin-releasing factor-binding protein is produced by human placenta and intrauterine tissues.

1993 • 109 citations

Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction.

1995 • 103 citations

The corticotropin-releasing hormone system in the regulation of energy balance in obesity

2000 • 103 citations

The Protooncogene c-fosIs Induced by Corticotropin-Releasing Factor and Stimulates Proopiomelanocortin Gene Transcription in Pituitary Cells

1991 • 103 citations

Localization of Agonist- and Antagonist-Binding Domains of Human Corticotropin-Releasing Factor Receptors

1997 • 103 citations

Urocortins and the regulation of gastrointestinal motor function and visceral pain

2004 • 101 citations

Drosophila CG8422encodes a functional diuretic hormone receptor

2004 • 101 citations

Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas

2005 • 99 citations

Expression and Coupling Characteristics of the CRH and Orexin Type 2 Receptors in Human Fetal Adrenals

2001 • 98 citations

Phosphorylation of Serine 1105 by Protein Kinase A Inhibits Phospholipase Cβ3 Stimulation by Gαq

1998 • 98 citations

Role of stress peptides during human pregnancy and labour

2002 • 97 citations

Corticotropin-Releasing Factor Synapses within the Paraventricular Nucleus of the Hypothalamus

1989 • 95 citations

Specificity and Regulation of Extracellularly Regulated Kinase1/2 Phosphorylation through Corticotropin-Releasing Factor (CRF) Receptors 1 and 2β by the CRF/Urocortin Family of Peptides

2003 • 95 citations

Determination of Bradykinin B2 Receptor in Vivo Phosphorylation Sites and Their Role in Receptor Function

2001 • 95 citations

Molecular and functional characterization of novel CRFR1 isoforms from the skin

2004 • 94 citations

Mitogen-Activated Protein Kinase Signaling in the Hippocampus and Its Modulation by Corticotropin-Releasing Factor Receptor 2: A Possible Link between Stress and Fear Memory

2003 • 94 citations

Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice.

1998 • 94 citations

Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization

2002 • 93 citations

The First Extracellular Domain of Corticotropin Releasing Factor-R1 Contains Major Binding Determinants for Urocortin and Astressin*

1998 • 92 citations

Corticotropin-releasing Hormone Induces Fas Ligand Production and Apoptosis in PC12 Cells via Activation of p38 Mitogen-activated Protein Kinase

2002 • 92 citations

Structural aspects of heterotrimeric G-protein signaling

1997 • 91 citations

A soluble mouse brain splice variant of type 2α corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity

2005 • 90 citations

Corticotropin-Releasing Hormone Directly Stimulates Cortisol and the Cortisol Biosynthetic Pathway in Human Fetal Adrenal Cells

2005 • 89 citations

Altered expression of type 2 CRH receptor mRNA in the VMH by glucocorticoids and starvation

1998 • 89 citations

Decreased Type 2 Corticotropin-Releasing Hormone Receptor mRNA Expression in the Ventromedial Hypothalamus during Repeated Immobilization Stress

1999 • 89 citations

Corticotropin-Releasing Factor Type 1 and Type 2α Receptors Regulate Phosphorylation of Calcium/Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and Activation of p42/p44 Mitogen-Activated Protein Kinase

1999 • 87 citations

Evolution of the Corticotropin‐releasing Hormone Signaling System and Its Role in Stress‐induced Phenotypic Plasticity

1999 • 87 citations

Expression of Urocortin III/Stresscopin in Human Heart and Kidney

2004 • 86 citations

CRF₂ receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators

2004 • 86 citations

Agonist-specific receptor conformations

1997 • 86 citations

Mouse Corticotropin-Releasing Factor Receptor Type 2α Gene: Isolation, Distribution, Pharmacological Characterization and Regulation by Stress and Glucocorticoids

2004 • 85 citations

Expression of Corticotropin-Releasing Hormone and Its R1 receptor in Human Endometrial Stromal Cells

1997 • 83 citations

A Variant of the Human Corticotropin-Releasing Factor (CRF) Receptor: Cloning, Expression, and Pharmacology

1994 • 82 citations

Localization of Ligand-Binding Domains of Human Corticotropin-Releasing Factor Receptor: A Chimeric Receptor Approach

1997 • 82 citations

Urocortin Stimulates Placental Adrenocorticotropin and Prostaglandin Release and Myometrial Contractility in Vitro

1999 • 81 citations

Brain Region-Specific Neuroprotective Action and Signaling of Corticotropin-Releasing Hormone in Primary Neurons

2003 • 80 citations

Corticotropin-Releasing Hormone System in Human Adipose Tissue

2004 • 80 citations

Expression, Purification, and Characterization of a Soluble Form of the First Extracellular Domain of the Human Type 1 Corticotropin Releasing Factor Receptor

2001 • 80 citations

Corticotropin-Releasing Hormone (CRH) and Urocortin Act through Type 1 CRH Receptors to Stimulate Dehydroepiandrosterone Sulfate Production in Human Fetal Adrenal Cells

2005 • 78 citations

Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model

2004 • 78 citations

Potential signalling pathways underlying corticotrophin‐releasing hormone‐mediated neuroprotection from excitotoxicity in rat hippocampus

2002 • 77 citations

Regulation of Corticotropin-Releasing Hormone Type 2 Receptors by Multiple Promoters and Alternative Splicing: Identification of Multiple Splice Variants

2003 • 77 citations

Identification of Amino Acids in the N‐Terminal Domain of Corticotropin‐Releasing Factor Receptor 1 that Are Important Determinants of High‐Affinity Ligand Binding

1999 • 76 citations

Urocortin-Deficient Mice Display Normal Stress-Induced Anxiety Behavior and Autonomic Control but an Impaired Acoustic Startle Response

2002 • 76 citations

Corticotropin-Releasing Hormone (CRH) Downregulates the Function of Its Receptor (CRF1) and Induces CRF1 Expression in Hippocampal and Cortical Regions of the Immature Rat Brain

2002 • 75 citations

Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line.

1988 • 74 citations

Urocortin, a Newly Identified Corticotropin-Releasing Factor-Related Mammalian Peptide, Stimulates Atrial Natriuretic Peptide and Brain Natriuretic Peptide Secretions from Neonatal Rat Cardiomyocytes

1998 • 74 citations

Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells

2002 • 74 citations

A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.

1990 • 73 citations

Characterization of Corticotropin-Releasing Hormone Binding Protein in Human Plasma by Chemical Cross-Linking and its Binding during Pregnancy*

1988 • 73 citations

Ligand Affinity for Amino-Terminal and Juxtamembrane Domains of the Corticotropin Releasing Factor Type I Receptor: Regulation by G-Protein and Nonpeptide Antagonists

2004 • 73 citations

Corticotropin-Releasing Factor Receptor 1 in Mouse Spleen: Expression After Immune Stimulation and Identification of Receptor-Bearing Cells

1999 • 73 citations

Modulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Mature Human Subcutaneous Adipocytes by Hypothalamic Messengers

2003 • 73 citations

Ancient evolution of stress-regulating peptides in vertebrates

2004 • 72 citations

Extracellular Cysteines of the Corticotropin-Releasing Factor Receptor Are Critical for Ligand Interaction^†

1997 • 71 citations

Heterogeneity between Brain and Pituitary Corticotropin-Releasing Factor Receptors Is Due To Differential Glycosylation

1989 • 70 citations

Regulation of Corticotropin-Releasing Hormone Receptor Type 1α Signaling: Structural Determinants for G Protein-Coupled Receptor Kinase-Mediated Phosphorylation and Agonist-Mediated Desensitization

2004 • 69 citations

The Human Placenta and Fetal Membranes Express the Corticotropin-Releasing Hormone Receptor 1α (CRH-1α) and the CRH-C Variant Receptor¹

1998 • 69 citations

Regulation of Corticotropin-Releasing Factor Receptor Type 2β Messenger Ribonucleic Acid in the Rat Cardiovascular System by Urocortin, Glucocorticoids, and Cytokines*

2000 • 69 citations

Leptin Effects on the Expression of Type‐2 CRH Receptor mRNA in the Ventromedial Hypothalamus in the Rat

1999 • 69 citations

Expression of CRHR1 and CRHR2 in Mouse Pituitary and Adrenal Gland: Implications for HPA System Regulation

2001 • 67 citations

CRH Inhibits Cell Growth of Human Endometrial Adenocarcinoma Cells via CRH-Receptor 1-Mediated Activation of cAMP-PKA Pathway

2002 • 67 citations

Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors

2003 • 67 citations

Altered Serotonergic Neurotransmission but Normal Hypothalamic–Pituitary–Adrenocortical Axis Activity in Mice Chronically Treated with the Corticotropin-Releasing Hormone Receptor Type 1 Antagonist NBI 30775

2003 • 66 citations

Urocortin II Is Expressed in Human Pregnant Myometrial Cells and Regulates Myosin Light Chain Phosphorylation: Potential Role of the Type-2 Corticotropin-Releasing Hormone Receptor in the Control of Myometrial Contractility

2003 • 66 citations

Constitutive activation of tethered-peptide/ corticotropin-releasing factor receptor chimeras

2000 • 66 citations

Human Corticotropin-Releasing Hormone Receptor: Differences in Subtype Expression between Pregnant and Nonpregnant Myometria¹

1998 • 66 citations

Autonomic and Behavioral Effects of Centrally Administered Corticotropin-Releasing Factor in Rats

1991 • 64 citations

Ectopic Expression of the CRF‐binding Protein: Minor Impact on HPA Axis Regulation but Induction of Sexually Dimorphic Weight Gain

1998 • 64 citations

Regulation of hypothalamic and pituitary corticotropin-releasing hormone receptor messenger ribonucleic acid by adrenalectomy and glucocorticoids.

1995 • 63 citations

Regulation of Corticotropin‐Releasing Factor Receptor Function in Human Y‐79 Retinoblastoma Cells: Rapid and Reversible Homologous Desensitization but Prolonged Recovery

1997 • 62 citations

Expression and effects of metabotropic CRF₁and CRF₂receptors in rat small intestine

2005 • 62 citations

Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptor.

1995 • 61 citations

Association of human corticotropin-releasing hormone to its binding protein in blood may trigger clearance of the complex.

1994 • 61 citations

Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity

2004 • 60 citations

Distinct Conformations of the Corticotropin Releasing Factor Type 1 Receptor Adopted following Agonist and Antagonist Binding Are Differentially Regulated

2005 • 59 citations

Preeclampsia Is Associated with Impaired Regulation of the Placental Nitric Oxide-Cyclic Guanosine Monophosphate Pathway by Corticotropin-Releasing Hormone (CRH) and CRH-Related Peptides

2005 • 59 citations

Corticotropin-Releasing Hormone (CRH) Downregulates Interleukin-18 Expression in Human HaCaT Keratinocytes by Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Pathway

2005 • 59 citations

Vasodilative Effects of Urocortin II via Protein Kinase A and a Mitogen-activated Protein Kinase in Rat Thoracic Aorta

2003 • 59 citations

A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: Implications for the design of agonists and antagonists

2001 • 59 citations

Corticotropin-Releasing Hormone-Mediated Induction of Intracellular Signaling Pathways and Brain-Derived Neurotrophic Factor Expression Is Inhibited by the Activation of the Endocannabinoid System

2005 • 58 citations

The Genomic Structure of the Rat Corticotropin Releasing Factor Receptor

1996 • 58 citations

Cross reactivity studies of CRF-related peptides on insect Malpighian tubules

1995 • 57 citations

Differential regulation of corticotropin-releasing hormone mRNA in rat brain

1990 • 57 citations

Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes

2004 • 57 citations

Role of Mitogen-Activated Protein Kinase Pathway in Prostaglandin F2α-Induced Rat Puerperal Uterine Contraction

1997 • 57 citations

Corticotropin Releasing Factor Receptor Type II (CRF2) Messenger Ribonucleic Acid Levels in the Hypothalamic Ventromedial Nucleus of the Infant Rat Are Reduced by Maternal Deprivation

1997 • 56 citations

A Soluble Form of the First Extracellular Domain of Mouse Type 2β Corticotropin-releasing Factor Receptor Reveals Differential Ligand Specificity

2003 • 56 citations

Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity

2004 • 55 citations

Urocortin-induced relaxation in the human internal mammary artery

2004 • 55 citations

Transcriptional Activation of the Macrophage Migration-Inhibitory Factor Gene by the Corticotropin-Releasing Factor is Mediated by the Cyclic Adenosine 3′,5′-Monophosphate Responsive Element-Binding Protein CREB in Pituitary Cells

1998 • 55 citations

Receptors and Actions of Corticotropin-Releasing Hormone in the Primate Pituitary Gland

1987 • 54 citations

NF-κB Participates in the Corticotropin-releasing, Hormone-induced Regulation of the Pituitary Proopiomelanocortin Gene

2004 • 53 citations

Corticotropin‐releasing factor (CRF) rapidly suppresses apoptosis by acting upstream of the activation of caspases

2003 • 53 citations

Expression of Genes Encoding Corticotropin-Releasing Factor (CRF), Type 1 CRF Receptor, and CRF-Binding Protein and Localization of the Gene Products in the Human Ovary1

1997 • 52 citations

A Role for a Helical Connector between Two Receptor Binding Sites of a Long-chain Peptide Hormone

2000 • 52 citations

Modified yeast cells to investigate the coupling of G protein‐coupled receptors to specific G proteins

2003 • 51 citations

Spontaneous and Receptor-Controlled Soluble Guanylyl Cyclase Activity in Anterior Pituitary Cells

2001 • 51 citations

Signal Transduction Characteristics of the Corticotropin-Releasing Hormone Receptors in the Feto-Placental Unit

2000 • 50 citations

Rapid Agonist-Induced Phosphorylation of the Human CRF Receptor, Type 1: A Potential Mechanism for Homologous Desensitization

2000 • 50 citations

The Alternatively Spliced Δe13 Transcript of the Rabbit Calcitonin Receptor Dimerizes with the C1a Isoform and Inhibits Its Surface Expression

2003 • 49 citations

Mutation and Expression Analysis of Corticotropin-Releasing Factor 1 Receptor in Adrenocorticotropin-Secreting Pituitary Adenomas1

1998 • 49 citations

Corticotropin-releasing hormone stimulation of Ca2+ entry in corticotropes is partially dependent on protein kinase A.

1995 • 49 citations

Promoter Analysis of Human Corticotropin-Releasing Factor (CRF) Type 1 Receptor and Regulation by CRF and Urocortin

2004 • 49 citations

Activation of Protein Kinase C by Oxytocin Inhibits the Biological Activity of the Human Myometrial Corticotropin-Releasing Hormone Receptor at Term*

1999 • 48 citations

Modulation of CRF-R1 mRNA in rat anterior pituitary by dexamethasone: Correlation with POMC mRNA

1996 • 47 citations

Protein Kinase A-Induced Negative Regulation of the Corticotropin-Releasing Hormone R1α Receptor-Extracellularly Regulated Kinase Signal Transduction Pathway: The Critical Role of Ser³⁰¹for Signaling Switch and Selectivity

2003 • 46 citations

Urocortin 1, Urocortin 3/Stresscopin, and Corticotropin-Releasing Factor Receptors in Human Adrenal and Its Disorders

2005 • 46 citations

Reduced Expression of Corticotropin-Releasing Hormone Receptor Type-1α in Human Preeclamptic and Growth-Restricted Placentas

2003 • 44 citations

GRK3 regulation during CRF- and urocortin-induced CRF1 receptor desensitization

2002 • 44 citations

Regulation of the Coupling to Different G Proteins of Rat Corticotropin-releasing Factor Receptor Type 1 in Human Embryonic Kidney 293 Cells

2004 • 44 citations

Regulation of Nuclear Factor-κB by Corticotropin-Releasing Hormone in Mouse Thymocytes

2002 • 43 citations

Synergistic role of cAMP and IP3 in corticotropin-releasing hormone-induced cell shape changes in invertebrate immunocytes

2000 • 43 citations

Human Corticotropin-Releasing Hormone Receptor: Differences in Subtype Expression between Pregnant and Nonpregnant Myometria

1998 • 40 citations

The role of the fourth extracellular domain of the rat corticotropin‐releasing factor receptor type 1 in ligand binding

1999 • 39 citations

Corticotropin Releasing Factor Receptor Type 1: Molecular Cloning and Investigation of Alternative Splicing in the Hamster Skin

2002 • 38 citations

Mediation of Corticotropin Releasing Factor Type 1 Receptor Phosphorylation and Desensitization by Protein Kinase C: A Possible Role in Stress Adaptation

2003 • 37 citations

Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of β‐arrestin 1 recruitment

2004 • 37 citations

Functional and protein chemical characterization of the N‐terminal domain of the rat corticotropin‐releasing factor receptor 1

2001 • 37 citations

The Δe13 Isoform of the Calcitonin Receptor Forms a Six-Transmembrane Domain Receptor with Dominant-Negative Effects on Receptor Surface Expression and Signaling

2005 • 36 citations

Localization of the Human CRF2 Receptor to 7p21–p15 by Radiation Hybrid Mapping and FISH Analysis

1997 • 34 citations

Expression and signalling characteristics of the corticotrophin-releasing hormone receptors during the implantation phase in the human endometrium

2004 • 34 citations

A Natural Variant Type II G Protein-coupled Receptor for Vasoactive Intestinal Peptide with Altered Function

2004 • 34 citations

Immunopathogenesis of Rheumatic Diseases in the Context of Neuroendocrine Interactions

2002 • 34 citations

Juxtamembrane Region of the Amino Terminus of the Corticotropin Releasing Factor Receptor Type 1 Is Important for Ligand Interaction

2001 • 33 citations

Divergent effects of corticotropin releasing hormone on endothelial cell nitric oxide synthase are associated with different expression of CRH type 1 and 2 receptors

2001 • 33 citations

Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype

2004 • 32 citations

Corticotropin-Releasing Factor (CRF) Agonists Stimulate Testosterone Production in Mouse Leydig Cells through CRF Receptor-1*

1998 • 32 citations

Corticotropin‐Releasing Hormone Signaling in Synovial Tissue Vascular Endothelium Is Mediated through the cAMP/CREB Pathway

2002 • 32 citations

Receptor-Controlled Phosphorylation of α₁Soluble Guanylyl Cyclase Enhances Nitric Oxide-Dependent Cyclic Guanosine 5′-Monophosphate Production in Pituitary Cells

2003 • 32 citations

Localization and Characterization of a Short Isoform of the Corticotropin-Releasing Factor Receptor Type 2α (CRF2α-tr) in the Rat Brain

2001 • 32 citations

Regulation of corticotropin-releasing factor receptor type 2β mRNA via cyclic AMP pathway in A7r5 aortic smooth muscle cells

2003 • 31 citations

Pharmacological characterization of recombinant rat corticotropin releasing factor binding protein using different sauvagine analogs

2001 • 31 citations

Association of human corticotropin-releasing hormone to its binding protein in blood may trigger clearance of the complex

1994 • 31 citations

Multiple Sites of Control of Type-1 Corticotropin Releasing Hormone Receptor Levels in the Pituitary

2002 • 30 citations

Basal and Interleukin-1β-Stimulated Prostaglandin Production from Cultured Human Myometrial Cells: Differential Regulation by Corticotropin- Releasing Hormone¹

1999 • 29 citations

Persistent corticotropin-releasing factor1 receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32

2001 • 29 citations

N-glycosylation of CRF receptor type 1 is important for its ligand-specific interaction

2001 • 28 citations

Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells.

1992 • 27 citations

A New Role for Corticotropin-Releasing Factor Receptor-2 Suppression of Vascularization

2003 • 27 citations

Involvement of cAMP‐Response Element Binding Protein in Corticotropin‐Releasing Factor (CRF)‐Induced Down‐Regulation of CRF Receptor 1 Gene Expression in Rat Anterior Pituitary Cells

2002 • 27 citations

G Protein-Coupled Receptor Kinase 2 Involvement in Desensitization of Corticotropin-Releasing Factor (CRF) Receptor Type 1 by CRF in Murine Corticotrophs

2005 • 26 citations

Corticotropin-releasing factor antagonists, binding-protein and receptors: implications for central nervous system disorders

1999 • 26 citations

Corticotropin-releasing factor-like peptides increase cytosolic [Ca2+] in human epidermoid A-431 cells

1997 • 26 citations

Control of Intracellular Signalling by Corticotropin-Releasing Hormone in Human Myometrium

2001 • 26 citations

Expression of Genes Encoding Corticotropin-Releasing Factor (CRF), Type 1 CRF Receptor, and CRF-Binding Protein and Localization of the Gene Products in the Human Ovary

1997 • 25 citations

Transcriptional Response to Corticotropin-Releasing Factor in AtT-20 Cells

2004 • 23 citations

Mutation and Expression Analysis of Corticotropin-Releasing Factor 1 Receptor in Adrenocorticotropin-Secreting Pituitary Adenomas

1998 • 23 citations

Urocortin 2 induces tyrosine hydroxylase phosphorylation in PC12 cells

2005 • 22 citations

The Cushing Syndromes

1990 • 22 citations

Homologous desensitization of human corticotropin-releasing factor, receptor in stable transfected mouse fibroblast cells

1996 • 20 citations

Mechanisms of relaxation by urocortin in renal arteries from male and female rats

2003 • 20 citations

Human corticotropin-releasing hormone receptor gene (CRHR) is located on the long arm of chromosome 17 (17q12?qter)

1994 • 20 citations

Corticotropin-Releasing Hormone Stimulates the Expression of the Steroidogenic Acute Regulatory Protein in MA-10 Mouse Cells1

1997 • 20 citations

Stimulation by Corticotropin-Releasing Factor of Atrial Natriuretic Peptide and Brain Natriuretic Peptide Secretions from Cultured Neonatal Rat Cardiomyocytes

1996 • 19 citations

Role of Corticotropin-Releasing Factor Receptor Type 2β in Urocortin-Induced Vasodilation of Rat Aortas

2004 • 18 citations

Determinants of Corticotropin Releasing Factor. Receptor Selectivity of Corticotropin Releasing Factor Related Peptides

2004 • 17 citations

Effects of glucocorticoid on corticotropin-releasing hormone gene regulation by second messenger pathways in NPLC and AtT-20 cells

1992 • 16 citations

Selective anorexigenic effects of corticotropin releasing hormone in the rhesus monkey

1991 • 16 citations

Participation of Maternal and Fetal CRH in Early Phases of Human Implantation: The Role of Antalarmin

2004 • 13 citations

Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to Chromosome 6

1997 • 7 citations

Localization of the corticotropin-releasing hormone receptor gene on mouse Chromosome 11

1995 • 7 citations