Roles of G‐protein‐coupled receptor dimerization

Mammalian Sweet Taste Receptors

2001 • 1,550 citations

An amino-acid taste receptor

2002 • 1,419 citations

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

2000 • 1,197 citations

Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

2000 • 866 citations

Rhodopsin dimers in native disc membranes

2003 • 734 citations

A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

2000 • 666 citations

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 631 citations

Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes

2003 • 591 citations

G-Protein-coupled receptor oligomerization and its potential for drug discovery

2002 • 584 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

Oligomerization of μ- and δ-Opioid Receptors

2000 • 545 citations

Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

2000 • 528 citations

Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors

2002 • 494 citations

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

2000 • 487 citations

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

2000 • 465 citations

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

2001 • 453 citations

Dopamine D ₁ and adenosine A ₁ receptors form functionally interacting heteromeric complexes

2000 • 437 citations

Adenosine A2A-Dopamine D2 Receptor-Receptor Heteromerization

2003 • 424 citations

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways

2001 • 423 citations

Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate Synergy

2000 • 393 citations

Mechanism of Transdominant Inhibition of CCR5-mediated HIV-1 Infection by ccr5Δ32

1997 • 371 citations

Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function

2001 • 363 citations

GABAB receptors – the first 7TM heterodimers

1999 • 345 citations

G-protein-coupled receptors function as oligomers in vivo

2000 • 313 citations

Homo- and Heterodimerization of Somatostatin Receptor Subtypes

2001 • 312 citations

Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer

2002 • 311 citations

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 304 citations

Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis

2003 • 303 citations

Export from the Endoplasmic Reticulum Represents the Limiting Step in the Maturation and Cell Surface Expression of the Human δ Opioid Receptor

2000 • 285 citations

The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer

2003 • 285 citations

Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein

2003 • 270 citations

Heterodimerization of Somatostatin and Opioid Receptors Cross-modulates Phosphorylation, Internalization, and Desensitization

2002 • 259 citations

Dual Inhibition of β-Adrenergic and Angiotensin II Receptors by a Single Antagonist

2003 • 239 citations

Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration.

1995 • 239 citations

The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

1999 • 229 citations

Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor

2003 • 222 citations

β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy

2002 • 210 citations

Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors

2002 • 209 citations

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

2002 • 207 citations

Newly Synthesized Human δ Opioid Receptors Retained in the Endoplasmic Reticulum Are Retrotranslocated to the Cytosol, Deglycosylated, Ubiquitinated, and Degraded by the Proteasome

2001 • 206 citations

Truncated V2 Vasopressin Receptors as Negative Regulators of Wild-Type V2 Receptor Function

1998 • 196 citations

Constitutive and Agonist-dependent Homo-oligomerization of the Thyrotropin-releasing Hormone Receptor

2001 • 194 citations

Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells

2002 • 186 citations

Metabotropic Glutamate 1α and Adenosine A1 Receptors Assemble into Functionally Interacting Complexes

2001 • 179 citations

Evidence for Adenosine/Dopamine Receptor Interactions Indications for Heteromerization

2000 • 169 citations

Inhibition of Gonadotropin-Releasing Hormone Receptor Signaling by Expression of a Splice Variant of the Human Receptor

1997 • 158 citations

The Dopamine D3 Receptor Interacts with Itself and the Truncated D3 Splice Variant D3nf: D3-D3nf Interaction Causes Mislocalization of D3 Receptors

2000 • 152 citations

Oligomerization of the α1a- and α1b-Adrenergic Receptor Subtypes

2003 • 152 citations

Gonadotropin-releasing Hormone Receptor Microaggregation

2001 • 136 citations

C5a Receptor Oligomerization

2003 • 132 citations

Homodimerization of Neuropeptide Y Receptors Investigated by Fluorescence Resonance Energy Transfer in Living Cells

2003 • 128 citations

Agonist-dependent Dissociation of Oligomeric Complexes of G Protein-coupled Cholecystokinin Receptors Demonstrated in Living Cells Using Bioluminescence Resonance Energy Transfer

2001 • 125 citations

Heterodimerization of α2A- and β1-Adrenergic Receptors

2003 • 121 citations

The Extracellular N-terminal Domain and Transmembrane Domains 1 and 2 Mediate Oligomerization of a Yeast G Protein-coupled Receptor

2002 • 121 citations

Ligand-dependent Inhibition of Oligomerization at the Human Thyrotropin Receptor

2002 • 120 citations

Assembly, sorting, and exit of oligomeric proteins from the endoplasmic reticulum

1998 • 108 citations

Ligand-independent CXCR2 Dimerization

2003 • 106 citations

G protein-linked receptors: pharmacological evidence for the formation of heterodimers.

1999 • 91 citations

Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)

2002 • 82 citations

C5a Receptor Oligomerization

2003 • 68 citations

Naturally Occurring Deletional Mutation in the C-Terminal Cytoplasmic Tail of CCR5 Affects Surface Trafficking of CCR5

2001 • 68 citations

Binding of Agonist but Not Antagonist Leads to Fluorescence Resonance Energy Transfer between Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptors

2001 • 61 citations

Coexpression of δ-Opioid Receptors with μ Receptors in GH₃ Cells Changes the Functional Response to μ Agonists from Inhibitory to Excitatory

2003 • 59 citations

Dimerization and Phosphorylation of Thyrotropin-releasing Hormone Receptors Are Modulated by Agonist Stimulation

2002 • 51 citations

Self-Association and Raft Localization of Functional Luteinizing Hormone Receptors

2003 • 43 citations

Membrane Organization of Luteinizing Hormone Receptors Differs between Actively Signaling and Desensitized Receptors

2003 • 42 citations

Agonist‐independent and ‐dependent oligomerization of dopamine D₂ receptors by fusion to fluorescent proteins

2001 • 39 citations

Heterodimerization of 2A - and 1 -Adrenergic Receptors*

2003 • 25 citations