Receptor-Mediated Adenylyl Cyclase Activation Through XLαs, the Extra-Large Variant of the Stimulatory G Protein α-Subunit

Culture of Animal Cells

1983 • 3,334 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

Untitled

1995 • 536 citations

Culture of animal cells: A manual of basic technique

1995 • 471 citations

Src Tyrosine Kinase Is a Novel Direct Effector of G Proteins

2000 • 422 citations

Endocrine Manifestations of Stimulatory G Protein α-Subunit Mutations and the Role of Genomic Imprinting

2001 • 420 citations

Variable and tissue-specific hormone resistance in heterotrimeric G _s protein α-subunit (G _s α) knockout mice is due to tissue-specific imprinting of the G _s α gene

1998 • 406 citations

Crystal Structure of the Adenylyl Cyclase Activator G _{s α}

1997 • 310 citations

Imprinting in Albright's hereditary osteodystrophy.

1993 • 306 citations

Imprinting of the Gsα gene GNAS1 in the pathogenesis of acromegaly

2001 • 292 citations

Rapid GDP release from Gsα in patients with gain and loss of endocrine function

1994 • 288 citations

Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins

1998 • 286 citations

Paternally Inherited Inactivating Mutations of theGNAS1Gene in Progressive Osseous Heteroplasia

2002 • 282 citations

The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins

1998 • 264 citations

A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2

1999 • 244 citations

RGS-PX1, a GAP for Gα _s and Sorting Nexin in Vesicular Trafficking

2001 • 226 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Paternal Uniparental Isodisomy of Chromosome 20q—and the Resulting Changes in GNAS1 Methylation—as a Plausible Cause of Pseudohypoparathyroidism

2001 • 203 citations

Identification of a Methylation Imprint Mark within the Mouse Gnas Locus

2000 • 187 citations

An imprinted antisense transcript at the human GNAS1 locus

2000 • 165 citations

An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus

2000 • 160 citations

Molecular properties of the PTH/PTHrP receptor

2001 • 160 citations

Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism

2000 • 153 citations

GNAS1Lesions in Pseudohypoparathyroidism Ia and Ic: Genotype Phenotype Relationship and Evidence of the Maternal Transmission of the Hormonal Resistance

2002 • 128 citations

Parental origin of transcription from the human GNAS1 gene.

1994 • 120 citations

Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage

2001 • 117 citations

Alternative promoter and 5' exon generate a novel Gs alpha mRNA.

1990 • 114 citations

Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.

1987 • 111 citations

Characterization of the Extra-large G Protein α-Subunit XLαs

2000 • 111 citations

Residues in the Membrane-spanning and Extracellular Loop Regions of the Parathyroid Hormone (PTH)-2 Receptor Determine Signaling Selectivity for PTH and PTH-related Peptide

1997 • 91 citations

Analysis of the GNAS1 Gene in Albright’s Hereditary Osteodystrophy

2001 • 91 citations

Characterization of the Extra-large G Protein α-Subunit XLαs

2000 • 89 citations

Differential expression of novel Gsα signal transduction protein cDNA species

1991 • 78 citations

Tissue-Specific Expression of Antisense and Sense Transcripts at the Imprinted Gnas Locus

2000 • 64 citations

Analysis of the GNAS1 Gene in Albright's Hereditary Osteodystrophy

2001 • 53 citations

Genetic Variation of the Extra-large Stimulatory G Protein α-Subunit Leads to Gs Hyperfunction in Platelets and Is a Risk Factor for Bleeding

2001 • 53 citations

Gαs Transcripts Are Biallelically Expressed in the Human Kidney Cortex: Implications for Pseudohypoparathyroidism Type 1b

2001 • 51 citations

Expression of the extra-large G protein α-subunit XLαs in neuroepithelial cells and young neurons during development of the rat nervous system

2001 • 33 citations

A Proline-rich Region and Nearby Cysteine Residues Target XLαs to the Golgi Complex Region

2000 • 29 citations

Introduction to G-Protein-Coupled Signal Transduction and Human Disease

1998 • 18 citations

CORRECTIONS: XLαs is a new type of G protein

1995 • 14 citations

Hypoparathyroidism and Pseudohypoparathyroidism

1998 • 4 citations