Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model

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1977 • 4,272 citations

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

1990 • 1,362 citations

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

1998 • 919 citations

Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression

1995 • 917 citations

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

2001 • 911 citations

Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development

1998 • 883 citations

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

2001 • 877 citations

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

2000 • 836 citations

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

2000 • 698 citations

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

2001 • 647 citations

Corticotropin-releasing factor, norepinephrine, and stress

1999 • 623 citations

Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

1995 • 554 citations

Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression

2002 • 513 citations

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

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CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.

1995 • 444 citations

Primary structure of corticotropin-releasing factor from ovine hypothalamus.

1981 • 421 citations

Corticotropin Releasing Factor Receptors and Their Ligand Family

1999 • 421 citations

Modulation of Learning and Anxiety by Corticotropin-Releasing Factor (CRF) and Stress: Differential Roles of CRF Receptors 1 and 2

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4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor₁ Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders

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Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease

1995 • 229 citations

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

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Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): Development of CRFR2β-selective antisauvagine-30

1998 • 170 citations

Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses

2003 • 168 citations

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice

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AMINO ACID COMPOSITION AND SEQUENCE ANALYSIS OF SAUVAGINE, A NEW ACTIVE PEPTIDE FROM THE SKIN OF PHYLLOMEDUSA SAWAGEI

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Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning

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Pharmacology and Biology of Corticotropin-Releasing Factor (CRF) Receptors

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Corticotropin-releasing hormone receptors

2002 • 62 citations

A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: Implications for the design of agonists and antagonists

2001 • 59 citations

A Role for a Helical Connector between Two Receptor Binding Sites of a Long-chain Peptide Hormone

2000 • 52 citations

Functional and protein chemical characterization of the N‐terminal domain of the rat corticotropin‐releasing factor receptor 1

2001 • 37 citations

Structure–function relationship of different domains of the rat corticotropin-releasing factor receptor

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Pharmacological characterization of recombinant rat corticotropin releasing factor binding protein using different sauvagine analogs

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Differential responsiveness of CRF receptor subtypes to N-terminal truncation of peptidic ligands

2002 • 12 citations

Pharmacology and Biology of Corticotropin-Releasing Factor (CRF) Receptors

2002 • 8 citations