GRK3 regulation during CRF- and urocortin-induced CRF1 receptor desensitization

Seven-transmembrane-spanning receptors and heart function

2002 • 926 citations

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

1999 • 656 citations

A role for corticotropin releasing factor and urocortin in behavioral responses to stressors

1999 • 527 citations

The CRF peptide family and their receptors: yet more partners discovered

2002 • 525 citations

Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins

2002 • 519 citations

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

1998 • 501 citations

Functional Dissociation of μ Opioid Receptor Signaling and Endocytosis

1999 • 422 citations

Corticotropin Releasing Factor Receptors and Their Ligand Family

1999 • 421 citations

Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System

2000 • 342 citations

Reciprocal In Vivo Regulation of Myocardial G Protein–Coupled Receptor Kinase Expression by β-Adrenergic Receptor Stimulation and Blockade

1998 • 258 citations

Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase

1997 • 257 citations

Regulation of G Protein-Coupled Receptor Kinases

2000 • 213 citations

Role of CRF 1 and CRF 2 receptors in fear and anxiety

2001 • 188 citations

G-Protein–Coupled Receptor Kinase Activity in Hypertension

2000 • 140 citations

Partial agonists and G protein-coupled receptor desensitization

1999 • 139 citations

Urocortin, but Not Corticotropin-Releasing Hormone (CRH), Activates the Mitogen-Activated Protein Kinase Signal Transduction Pathway in Human Pregnant Myometrium: An Effect Mediated via R1α and R2β CRH Receptor Subtypes and Stimulation of Gq-Proteins

2000 • 117 citations

Degradation of the G Protein-coupled Receptor Kinase 2 by the Proteasome Pathway

1998 • 110 citations

Long-lasting stress sensitisation

2000 • 107 citations

Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2.

1995 • 106 citations

Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo.

2001 • 98 citations

Agonist-Dependent Modulation of G Protein-Coupled Receptor Kinase 2 by Mitogen-Activated Protein Kinases

2000 • 89 citations

Mechanisms of Receptor Regulation

1985 • 70 citations

Analysis of the Human G Protein–Coupled Receptor Kinase 2 (GRK2) Gene Promoter

2000 • 70 citations

G Protein-coupled Receptor Kinase 5 in Cultured Vascular Smooth Muscle Cells and Rat Aorta

1997 • 68 citations

Oxidative Stress Decreases G Protein-Coupled Receptor Kinase 2 in Lymphocytes via a Calpain-Dependent Mechanism

2002 • 65 citations

Regulation of Corticotropin‐Releasing Factor Receptor Function in Human Y‐79 Retinoblastoma Cells: Rapid and Reversible Homologous Desensitization but Prolonged Recovery

1997 • 62 citations

Albuterol-induced downregulation of Gsα accounts for pulmonary β2-adrenoceptor desensitization in vivo

2000 • 62 citations

Changes in the expression of G protein‐coupled receptor kinases and β‐arrestin 2 in rat brain during opioid tolerance and supersensitivity

2001 • 57 citations

The ligand‐selective Domains of Corticotropin‐Releasing Factor Type 1 and Type 2 Receptor Reside in Different Extracellular Domains

1999 • 51 citations

Rapid Agonist-Induced Phosphorylation of the Human CRF Receptor, Type 1: A Potential Mechanism for Homologous Desensitization

2000 • 50 citations

G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells

2001 • 41 citations

The CRF Receptor Structure, Function and Potential for Therapeutic Intervention.

2001 • 38 citations

Upregulation of G protein-linked receptor kinases with advancing age in rat aorta

2001 • 36 citations

Persistent corticotropin-releasing factor1 receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32

2001 • 29 citations

Extracellular signal‐regulated kinases control expression of G protein‐coupled receptor kinase 2 (GRK2)

2002 • 21 citations