Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

1997 • 529 citations

Familial breast-ovarian cancer locus on chromosome 17q12-q23

1991 • 513 citations

Signal transduction by fibroblast growth factor receptors

1999 • 419 citations

Replacement of Fhit in cancer cells suppresses tumorigenicity

1997 • 368 citations

Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation.

1988 • 357 citations

Analysis of Loss of Heterozygosity in 399 Premalignant Breast Lesions at 15 Genetic Loci

1998 • 338 citations

Stromal-epithelial interactions in adult organs

1985 • 315 citations

Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer.

1999 • 277 citations

Psoriatic Fibroblasts Induce Hyperproliferation of Normal Keratinocytes in a Skin Equivalent Model in Vitro

1985 • 220 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ("clinging ductal carcinoma in situ"): a simulator of normal mammary epithelium.

2000 • 202 citations

Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: a new tumor-associated chromosome rearrangement

1996 • 195 citations

Genetic events and the role of TGFβ in epithelial tumour progression

1999 • 166 citations

Genome-wide search for loss of heterozygosity shows extensive genetic diversity of human breast carcinomas.

1997 • 157 citations

Stromal regulation of epithelial function

1991 • 154 citations

Expression of the C-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression

1997 • 153 citations

Mechanisms of inactivation of E-cadherin in breast cancer cell lines.

1998 • 148 citations

Loss of heterozygosity at chromosome 16q in prostate adenocarcinoma: identification of three independent regions.

1997 • 142 citations

Normal Differentiation of Myeloid Leukaemic Cells induced by a Differentiation-inducing Protein

1972 • 138 citations

Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture.

1995 • 138 citations

Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.

1997 • 137 citations

Intestinal Epithelial‐Mesenchymal Cell Interactions

1998 • 128 citations

Intrauterine transplantation of rat basal cell carcinoma as a model for reconversion of malignant to benign growth.

1977 • 112 citations

Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region.

1996 • 109 citations

Clonal heterogeneity in fibroblast phenotype: Implications for the control of epithelial‐mesenchymal interactions

1987 • 103 citations

Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma.

1991 • 101 citations

Role of Basement Membranes in Cell Differentiation

1987 • 96 citations

Uterine and Vaginal Organ Growth Requires Epidermal Growth Factor Receptor Signaling from Stroma*

1998 • 95 citations

Inhibition of stromal matrix metalloproteases: Effects on breast-tumor promotion by fibroblasts

1998 • 91 citations

Alveolar soft-part sarcoma: Further evidence by FISH for the involvement of chromosome band 17q25

1998 • 87 citations

Gain of 17q24-qter detected by comparative genomic hybridization in malignant tumors from patients with von Recklinghausen's neurofibromatosis.

1996 • 77 citations

Abnormal properties of skin fibroblasts from patients with breast cancer

1984 • 75 citations

Loss of heterozygosity at 11q23.1 in breast carcinomas: Indication for involvement of a gene distal and close toATM

1997 • 72 citations

High levels of allele loss at the FHIT and ATM genes in non-comedo ductal carcinoma in situ and grade I tubular invasive breast cancers.

1996 • 70 citations

FIBROBLASTS FROM PATIENTS WITH BREAST CANCER SHOW ABNORMAL MIGRATORY BEHAVIOUR IN VITRO

1984 • 70 citations

Altered biochemical properties of actin in normal skin fibroblasts from individuals predisposed to dominantly inherited cancers.

1986 • 51 citations

Spontaneous transformation of human skin fibroblasts derived from neoplastic patients

1976 • 47 citations

Hepatocyte Growth Factor Is a Paracrine Regulator of Rat Prostate Epithelial Growth

1996 • 42 citations

Molecular aspects of early stages of breast cancer progression

1993 • 41 citations

p53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints

1999 • 40 citations

Molecular analysis of premalignant and carcinoma in situ lesions of the human breast.

1996 • 35 citations

Microsatellite instability and loss of heterozygosity in prostatic carcinomas: Comparison of primary tumors, and of corresponding recurrences after androgen-deprivation therapy and lymph-node metastases

1999 • 30 citations

An Integrated Physical and Gene Map of Human Distal Chromosome 17q24–Proximal 17q25 Encompassing Multiple Disease Loci

1999 • 28 citations

A new cis element is involved in the HER2 gene overexpression in human breast cancer cells.

1999 • 28 citations

The stroma and the control of cell growth

1986 • 27 citations

Evidence that Leydig cells in Sertoli-Leydig cell tumors have a reactive rather than a neoplastic profile

1999 • 24 citations

High levels of enhanced reactivation of herpes simplex virus in skin fibroblasts from various hereditary cancer-prone syndromes.

1992 • 18 citations

Introduction of the c-kit gene leads to growth suppression of a breast cancer cell line, MCF-7.

1996 • 17 citations

Abnormalities of the FHIT Transcripts in Osteosarcoma and Ewing Sarcoma

1998 • 12 citations