Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Cancer statistics, 1994

1994 • 1,345 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

Intratumor microvessel density as a prognostic factor in cancer.

1995 • 881 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Antioncogenes and human cancer.

1993 • 772 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

The molecular and cellular biology of wound repair

1996 • 562 citations

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.

1996 • 494 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

Halting angiogenesis suppresses carcinoma cell invasion

1997 • 430 citations

The keratinocyte handbook

1995 • 428 citations

Genetic analysis of indefinite division in human cells: identification of four complementation groups.

1988 • 358 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.

1994 • 324 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture.

1994 • 248 citations

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

1993 • 238 citations

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

1998 • 236 citations

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

1991 • 217 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

1996 • 212 citations

Mortality and immortality at the cellular level. A review.

1997 • 204 citations

Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.

1994 • 203 citations

Regulation of the cell cycle machinery by oncogenic ras.

1996 • 202 citations

SV40-lnduced Immortalization of Human Cells

1994 • 199 citations

Induction of Cellular Senescence in Immortalized Cells by Human Chromosome 1

1990 • 195 citations

Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4.

1991 • 179 citations

Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones

1989 • 164 citations

Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT

1997 • 142 citations

Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants

1998 • 138 citations

Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression.

1995 • 134 citations

The role of fibroblasts in tumor behavior

1995 • 125 citations

Differential modulation of epidermal keratinization in immortalized (HaCaT) and tumorigenic human skin keratinocytes (HaCaT-ras) by retinoic acid and extracellular Ca2+

1993 • 102 citations

Genetic and cellular basis of multistep carcinogenesis

1990 • 98 citations

Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events

1996 • 96 citations

Epithelial-Stromal Interactions in Basal Cell Cancer: The PDGF System

1994 • 90 citations

Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor‐inducing effect of wounding in initiated nmri mouse skin

1989 • 83 citations

Oral cancer : detection of patients and lesions at risk

1991 • 79 citations

Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells.

1995 • 75 citations

Environmental modulation of the expression of differentiation and malignancy in six human squamous cell carcinoma cell lines.

1985 • 74 citations

Biological properties of VEGF/VPF receptors

1996 • 73 citations

Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line.

1991 • 66 citations

Pathways of Ras Function: Connections to the Actin Cytoskeleton

1993 • 64 citations

Integrin and basement membrane normalization in mouse grafts of human keratinocytes – Implications for epidermal homeostasis

1997 • 64 citations

Progressive abrogation of TGF‐β‐1 and EGF growth control is associated with tumour progression in ras‐transfected human keratinocytes

1992 • 61 citations

Step-wise progression in human skin carcinogenesis in vitro involves mutational inactivation of p53, rasH oncogene activation and additional chromosome loss.

1995 • 51 citations

Malignant progression of an SV40-transformed human epidermal keratinocyte cell line

1987 • 46 citations

Carcinogenesis in human skin grafted to SCID mice.

1996 • 41 citations

Phenotypic and cytogenetic characteristics of different stages during spontaneous transformation of mouse keratinocytes in vitro.

1985 • 40 citations

Colorectal carcinogenesis: sequential steps in the in vitro immortalization and transformation of human colonic epithelial cells (review).

1990 • 38 citations

Immortalization of Human Cells and Its Mechanisms

1996 • 37 citations

Neoplastic Transformation in Human Cell Culture

1991 • 37 citations

Functional evidence for tumor-suppressor activity on chromosome 15 in human skin carcinoma cells and thrombospondin-1 as the potential suppressor

1997 • 21 citations

Role of elevated temperature in malignant transformation of mammalian cells in vztro

1980 • 15 citations

Failure of genotoxic carcinogens to produce tumors in human skin xenografts transplanted to SCID mice

1995 • 12 citations

In vitro transformation of human skin epithelial cells: Role of RAS oncogene in malignant progression

1990 • 11 citations

Altered Regulation of Growth and Differentiation at Different Stages of Transformation of Human Skin Keratinocytes

1991 • 6 citations

Carcinogenesis Studies of Human Cells: Reliable In Vitro Models

1994 • 5 citations