Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.
Data up to Jan 2025
Total Citations Per Year
Abstract
References (97)
Calcium's Role in Mechanotransduction during Muscle Development
2014 • 14,293 citations
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 • 9,986 citations
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
1996 • 3,454 citations
Integrins and Signal Transduction Pathways: the Road Taken
1995 • 3,002 citations
Integrins: Emerging Paradigms of Signal Transduction
1995 • 1,591 citations
Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10
1990 • 1,495 citations
How does the extracellular matrix direct gene expression?
1982 • 1,475 citations
Autocrine growth factors and cancer
1985 • 1,462 citations
Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
1997 • 1,444 citations
Regulation of development and differentiation by the extracellular matrix
1993 • 1,216 citations
Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.
1988 • 1,209 citations
Normal genetically mosaic mice produced from malignant teratocarcinoma cells.
1975 • 1,175 citations
Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.
1992 • 1,047 citations
Origins of Cell Polarity
1996 • 1,024 citations
The Lifetime Risk of Developing Breast Cancer
1993 • 928 citations
Primary culture of parenchymal liver cells on collagen membranes
1975 • 808 citations
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction
1996 • 772 citations
Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro
1989 • 746 citations
Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane
1989 • 700 citations
Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes
1977 • 641 citations
Multi‐faceted regulation of cell differentiation by extracellular matrix
1993 • 610 citations
Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas
1996 • 583 citations
Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.
1991 • 574 citations
Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.
1987 • 547 citations
Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.
1988 • 534 citations
How does extracellular matrix control capillary morphogenesis?
1989 • 466 citations
The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.
1995 • 425 citations
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.
1985 • 416 citations
A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression
1995 • 378 citations
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization.
1987 • 343 citations
Growth of normal human mammary cells in culture
1980 • 316 citations
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements.
1990 • 300 citations
Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.
1993 • 298 citations
Terminal differentiation of epidermal keratinocytes
1989 • 273 citations
Adhesion molecules in cancer: the role of integrins
1993 • 264 citations
Extracellular matrix regulates expression of the TGF-beta 1 gene.
1993 • 260 citations
Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.
1990 • 242 citations
A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium
1987 • 237 citations
A function for the integrin alpha 6 beta 4 in the hemidesmosome.
1991 • 225 citations
The Extracellular Matrix Coordinately Modulates Liver Transcription Factors and Hepatocyte Morphology
1991 • 224 citations
Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules.
1991 • 224 citations
Use of extracellular matrix components for cell culture
1987 • 217 citations
The mammary gland
1991 • 216 citations
The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay
1996 • 212 citations
The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture
1981 • 208 citations
Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma
1995 • 203 citations
Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin
1990 • 198 citations
Trisomy 7 in nonneoplastic cells
1993 • 187 citations
Laminin receptors for neurite formation.
1988 • 187 citations
Cytoskeletal and adhesion proteins as tumor suppressors
1997 • 185 citations
Widespread histologic distribution of the alpha 2 beta 1 integrin cell-surface collagen receptor.
1990 • 183 citations
Apical, basal, and lateral cues for epithelial polarization
1995 • 181 citations
Tumor progression in four mammary epithelial cell lines derived from the same patient.
1990 • 174 citations
Human tissues and cells in carcinogenesis research.
1987 • 173 citations
Matrigel induces thymosin β4 gene in differentiating endothelial cells
1995 • 170 citations
From laminin to lamin: regulation of tissue-specific gene expression by the ECM
1995 • 165 citations
A Novel Function for the nm23-H1 Gene: Overexpression in Human Breast Carcinoma Cells Leads to the Formation of Basement Membrane and Growth Arrest
1994 • 157 citations
The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells.
1989 • 155 citations
Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression.
1996 • 155 citations
Spontaneous In Vitro Immortalization of Breast Epithelial Cells from a Patient with Li-Fraumeni Syndrome
1995 • 152 citations
Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors
1995 • 147 citations
The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology.
1991 • 138 citations
The development of a functionally relevant cell culture model of progressive human breast cancer
1995 • 133 citations
Designer microenvironments for the analysis of cell and tissue function
1990 • 124 citations
Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo
1991 • 120 citations
The Extracellular Matrix in Epithelial Biology: Shared Molecules and Common Themes in Distant Phyla
1996 • 118 citations
Breast Cancer and Environmental Risk Factors: Epidemiological and Experimental Findings
1996 • 117 citations
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.
1996 • 115 citations
Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitro
1995 • 114 citations
Cell proliferation, extracellular matrix mineralization, and ovotransferrin transient expression during in vitro differentiation of chick hypertrophic chondrocytes into osteoblast-like cells
1993 • 112 citations
The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis
1997 • 109 citations
Teratocarcinomas and Other Neoplasms as Developmental Defects in Gene Expression
1981 • 109 citations
A cell line (HBL-100) established from human breast milk
1982 • 108 citations
Epithelial HBL-100 cell line derived from milk of an apparently healthy woman harbours SV40 genetic information
1985 • 96 citations
Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization.
1993 • 96 citations
Keratin Expression in the Mammary Gland
1987 • 94 citations
Clonal chromosome abnormalities in human breast carcinomas I. Twenty‐eight cases with primary disease
1993 • 89 citations
The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia.
1990 • 87 citations
Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.
1996 • 85 citations
Clonal chromosome abnormalities in human breast carcinomas II. Thirty‐four cases with metastatic disease
1993 • 79 citations
Integrins: Emerging Paradigms of Signal Transduction
1995 • 79 citations
Alteration of stromal protein and integrin expression in breast—a marker of premalignant change?
1992 • 78 citations
Loss of p53 protein during radiation transformation of primary human mammary epithelial cells.
1994 • 78 citations
Culture systems for study of human mammary epithelial cell proliferation, differentiation and transformation.
1993 • 73 citations
Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix.
1990 • 70 citations
Narrow and variable lines in the ultraviolet spectrum of the Seyfert galaxy NGC4151
1985 • 67 citations
Selective cell culture of primary breast carcinoma.
1995 • 62 citations
Cell adhesion molecules in the normal and cancerous mammary gland
1996 • 61 citations
Preparation and identification of human breast epithelial cells in culture
1980 • 56 citations
Altered Gene Expression of c-myc, Epidermal Growth Factor Receptor, Transforming Growth Factor-α, and c-erb-B2 in an Immortalized Human Breast Epithelial Cell Line, HMT-3522, Is Associated with Decreased Growth Factor Requirements
1992 • 54 citations
Modulation of Myoepithelial-Associated α6β4 Integrin in a Breast Cancer Cell Line Alters Invasive Potential
1997 • 52 citations
Gradual Selection of a Cellular Clone Presenting a Mutation at Codon 179 of the p53 Gene during Establishment of the Immortalized Human Breast Epithelial Cell Line HMT-3522
1994 • 36 citations
In vitro karyotype evolution and cytogenetic instability in the non-tumorigenic human breast epithelial cell line HMT-3522
1994 • 29 citations
Loss of p53 Protein During Radiation Transformation of Primary Human Mammary Epithelial Cells
1994 • 21 citations
Altered gene expression of c-myc, epidermal growth factor receptor, transforming growth factor-alpha, and c-erb-B2 in an immortalized human breast epithelial cell line, HMT-3522, is associated with decreased growth factor requirements.
1992 • 21 citations
Tumor cell-specific loss of p53 protein in a unique in vitro model of human breast tumor progression
1994 • 16 citations
Chapter 5 Methods for the Isolation and Culture of Normal Human Breast Epithelial Cells
1980 • 15 citations
Cited By (0)
No citing papers found in database