Isolation of Mutations that Disrupt Cooperative DNA Binding by the Drosophila Bicoid Protein

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

The development of Drosophila melanogaster

1994 • 3,057 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition

1992 • 1,411 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Shape representation in the inferior temporal cortex of monkeys

1995 • 979 citations

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

1996 • 948 citations

Homeodomain-DNA recognition

1994 • 784 citations

PCR primer: a laboratory manual.

2003 • 743 citations

The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo.

1988 • 736 citations

A new class of yeast transcriptional activators

1987 • 706 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Quantitative model for gene regulation by lambda phage repressor.

1982 • 596 citations

The OR control system of bacteriophage lambda

1985 • 524 citations

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

1994 • 506 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

A rapid method for localized mutagenesis of yeast genes

1992 • 456 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Guidebook to the homeobox genes

1994 • 399 citations

Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins

1996 • 393 citations

Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid

1986 • 386 citations

λ Repressor and cro—components of an efficient molecular switch

1981 • 385 citations

Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

1987 • 370 citations

[9] Quantitative DNase footprint titration: A method for studying protein-DNA interactions

1986 • 357 citations

Interactions between DNA-bound repressors govern regulation by the λ phage repressor

1979 • 329 citations

A Common Motif within the Negative Regulatory Regions of Multiple Factors Inhibits Their Transcriptional Synergy

2000 • 222 citations

A Genetic Model for Interaction of the Homeodomain Recognition Helix with DNA

1991 • 216 citations

Activation of posterior gap gene expression in the Drosophila blastoderm

1995 • 201 citations

Fusion of GAL4-VP16 to a steroid-binding domain provides a tool for gratuitous induction of galactose-responsive genes in yeast

1993 • 188 citations

Molecular mechanisms of cell-type determination in budding yeast

1995 • 184 citations

Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo

1998 • 180 citations

Structural studies of the engrailed homeodomain

1994 • 158 citations

A Genetic Switch: Gene Control and Phage

1987 • 157 citations

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 • 125 citations

The Drosophila morphogenetic protein Bicoid binds DNA cooperatively

1996 • 124 citations

Free energy coupling within macromolecules

1983 • 123 citations

Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo

1994 • 87 citations

Cooperativity mutants of the γδ resolvase identify an essential interdimer interaction

1990 • 81 citations

Yeast a1 and α2 Homeodomain Proteins Form a DNA-binding Activity with Properties Distinct from those of either Protein

1993 • 78 citations

Specific DNA recognition and intersite spacing are critical for action of the bicoid morphogen.

1994 • 74 citations

Interaction between two homeodomain proteins is specified by a short C-terminal tail

1994 • 59 citations

Homeodomain Proteins: Cooperating to be different

1995 • 56 citations

Specificity determinants for the interaction of lambda repressor and P22 repressor dimers.

1994 • 54 citations

Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator

1999 • 51 citations

Isolation of .lambda. repressor mutants with defects in cooperative operator binding

1993 • 49 citations

The Yeast α2 and Mcm1 Proteins Interact through a Region Similar to a Motif Found in Homeodomain Proteins of Higher Eukaryotes

1996 • 47 citations

Self-Assembly of Bacteriophage .lambda. cI Repressor: Effects of Single-Site Mutations on the Monomer-Dimer Equilibrium

1994 • 47 citations

Control of transcription by the bacteriophage P22 repressor

1982 • 43 citations

Single-Site Mutations in the C-Terminal Domain of Bacteriophage .lambda. cI Repressor Alter Cooperative Interactions between Dimers Adjacently Bound to OR

1994 • 43 citations

Highly Cooperative DNA Binding by the Coliphage HK022 Repressor

1993 • 37 citations

Identification of Drosophila Bicoid-interacting proteins using a custom two-hybrid selection

2000 • 35 citations

Genetic selection for mutations that impair the co‐operative binding of lambda repressor

1994 • 31 citations

Sequences Outside the Homeodomain of Bicoid Are Required for Protein-Protein Interaction

1996 • 30 citations

A genetic method for dissecting the mechanism of transcriptional activator synergy by identical activators

1999 • 21 citations

Self-association and DNA binding of .lambda. cI repressor N-terminal domains reveal linkage between sequence-specific binding and the C-terminal cooperativity domain

1994 • 17 citations

A variant of lambda repressor with an altered pattern of cooperative binding to DNA sites.

1995 • 17 citations

P22 repressor mutants deficient in co-operative binding and DNA loop formation.

1989 • 15 citations

Mutations affecting cooperative DNA binding of phage HK022 CI repressor 1 1Edited by M. Gottesman

1998 • 8 citations