Nucleocytoplasmic shuttling of transcription factors

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

STATs and Gene Regulation

1997 • 3,927 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A short amino acid sequence able to specify nuclear location

1984 • 2,529 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

1999 • 1,011 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Signaling to p53

1998 • 636 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

1998 • 610 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

Regulation of cell proliferation by the E2F transcription factors

1998 • 486 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

NTF2 mediates nuclear import of Ran

1998 • 459 citations

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

1997 • 403 citations

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

1995 • 398 citations

The Arginine-Rich Domains Present in Human Immunodeficiency Virus Type 1 Tat and Rev Function as Direct Importin β-Dependent Nuclear Localization Signals

1999 • 384 citations

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

1997 • 362 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

The nuclear pore complex: from molecular architecture to functional dynamics

1999 • 343 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp

1999 • 340 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway

1991 • 316 citations

Cotranslational Biogenesis of NF-κB p50 by the 26S Proteasome

1998 • 312 citations

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

1998 • 306 citations

Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT

1998 • 298 citations

NF-κB to the rescue: RELs, apoptosis and cellular transformation

1999 • 276 citations

Structure of the Amino-Terminal Protein Interaction Domain of STAT-4

1998 • 267 citations

Introduction to the E2F Family: Protein Structure and Gene Regulation

1996 • 249 citations

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery.

1989 • 246 citations

Importins and exportins: how to get in and out of the nucleus

1998 • 242 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

1995 • 215 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

Importin β Can Mediate the Nuclear Import of an Arginine-Rich Nuclear Localization Signal in the Absence of Importin α

1999 • 207 citations

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization

1997 • 195 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

1998 • 190 citations

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

1999 • 179 citations

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.

1983 • 160 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

Rapid targeting of nuclear proteins to the cytoplasm

1997 • 112 citations

STAT structure and function in signaling

1998 • 91 citations

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

1996 • 73 citations

The Carboxyl Terminus of Interferon-γ Contains a Functional Polybasic Nuclear Localization Sequence

1999 • 70 citations

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.

1992 • 69 citations

Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

1999 • 53 citations

Mechanism of expression and role in transcriptional control of the proto-oncogene NFKB-2/LYT-10.

1994 • 49 citations

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors

1997 • 48 citations

Loss of IκBα-Mediated Control over Nuclear Import and DNA Binding Enables Oncogenic Activation of c-Rel

1998 • 47 citations

Serine 32 and serine 36 of IκBα are directly phosphorylated by protein kinase CKII in Vitro

1999 • 32 citations

Association with E2F-1 governs intracellular trafficking and polyubiquitination of DP-1

1999 • 26 citations