CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1997 • 654 citations

Identification of different roles for RanGDP and RanGTP in nuclear protein import.

1996 • 644 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

Poliovirus RNA synthesis utilizes an RNP complex formed around the 5′-end of viral RNA.

1993 • 493 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

Synthetic peptides as nuclear localization signals

1986 • 472 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

A Novel Class of RanGTP Binding Proteins

1997 • 427 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

1997 • 371 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

A cap-binding protein complex mediating U snRNA export

1995 • 347 citations

A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

1997 • 335 citations

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

1995 • 334 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins

1996 • 306 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

A human nucleoporin-like protein that specifically interacts with HIV Rev

1995 • 268 citations

A Role for the M9 Transport Signal of hnRNP A1 in mRNA Nuclear Export

1997 • 249 citations

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery.

1989 • 246 citations

From nucleoporins to nuclear pore complexes

1997 • 243 citations

The Vertebrate GLFG Nucleoporin, Nup98, Is an Essential Component of Multiple RNA Export Pathways

1997 • 227 citations

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

1995 • 223 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process.

1983 • 202 citations

Importin Provides a Link between Nuclear Protein Import and U snRNA Export

1996 • 189 citations

Requirement of Guanosine Triphosphate-Bound Ran for Signal-Mediated Nuclear Protein Export

1997 • 183 citations

RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import.

1996 • 175 citations

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.

1983 • 160 citations

A G protein involved in nucleocytoplasmic transport: the role of Ran

1994 • 159 citations

Nucleo-cytoplasmic distribution of human hnrnp proteins: a search for the targeting domains in hnrnp a1

1995 • 158 citations

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β

1997 • 146 citations

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

1996 • 137 citations

Ran-binding Protein 1 (RanBP1) Forms a Ternary Complex with Ran and Karyopherin β and Reduces Ran GTPase-activating Protein (RanGAP) Inhibition by Karyopherin β

1997 • 134 citations

Cytosolic factors in nuclear transport: What's importin?

1994 • 133 citations

Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA.

1992 • 128 citations

RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.

1996 • 118 citations

Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.

1992 • 116 citations

Transportin: Nuclear Transport Receptor of a Novel Nuclear Protein Import Pathway

1996 • 114 citations

Identification of two HSP70-related Xenopus oocyte proteins that are capable of recycling across the nuclear envelope.

1990 • 108 citations

HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs

1996 • 106 citations

The yeast nucleoporin Rip1p contributes to multiple export pathways with no essential role for its FG-repeat region

1997 • 95 citations

A Role for Nucleoporin FG Repeat Domains in Export of Human Immunodeficiency Virus Type 1 Rev Protein and RNA from the Nucleus

1996 • 90 citations

Interaction of cellular proteins with the leukemia specific fusion proteins DEK-CAN and SET-CAN and their normal counterpart, the nucleoporin CAN.

1996 • 85 citations

A family of Ran binding proteins that includes nucleoporins.

1995 • 79 citations

A GTPase distinct from Ran is involved in nuclear protein import.

1996 • 50 citations

Nuclear Export Pathways of tRNA and 40 S Ribosomes Include both Common and Specific Intermediates

1995 • 40 citations

Nuclear Localization of a Cap-binding Protein Complex

1995 • 28 citations

A PCR shortcut to oocyte expression.

1993 • 10 citations