NTF2 mediates nuclear import of Ran

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1991 • 703 citations

Identification of different roles for RanGDP and RanGTP in nuclear protein import.

1996 • 644 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

Importin beta , transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

1998 • 524 citations

The Cell Nucleus

1966 • 522 citations

Movement of a karyophilic protein through the nuclear pores of oocytes.

1984 • 510 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

A Novel Class of RanGTP Binding Proteins

1997 • 427 citations

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

1995 • 398 citations

Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

1995 • 385 citations

Identification of a tRNA-Specific Nuclear Export Receptor

1998 • 379 citations

The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

1989 • 367 citations

Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

1997 • 365 citations

A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

1997 • 335 citations

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

1995 • 334 citations

Transport into and out of the cell nucleus

1998 • 332 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Identification of a nuclear export receptor for tRNA

1998 • 286 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Facilitated nuclear transport of histone H1 and other small nucleophilic proteins

1990 • 278 citations

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1993 • 261 citations

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins

1997 • 252 citations

RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

1997 • 250 citations

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

1995 • 247 citations

The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus.

1990 • 228 citations

Transport of macromolecules between the nucleus and the cytoplasm.

1998 • 207 citations

tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process.

1983 • 202 citations

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

1993 • 195 citations

RanBP2 associates with Ubc9p and a modified form of RanGAP1

1997 • 190 citations

Importin Provides a Link between Nuclear Protein Import and U snRNA Export

1996 • 189 citations

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form

1995 • 188 citations

Requirement of Guanosine Triphosphate-Bound Ran for Signal-Mediated Nuclear Protein Export

1997 • 183 citations

RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import.

1996 • 175 citations

Role of the Nuclear Transport Factor p10 in Nuclear Import

1996 • 166 citations

Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus

1997 • 163 citations

Ran-unassisted Nuclear Migration of a 97-kD Component of Nuclear Pore–targeting Complex

1997 • 160 citations

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

1996 • 155 citations

Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the ras-family GTPase ran 1 1Edited by I. B. Holland

1998 • 151 citations

Disassembly of RanGTP-Karyopherin β Complex, an Intermediate in Nuclear Protein Import

1997 • 147 citations

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β

1997 • 146 citations

Mutants in a yeast Ran binding protein are defective in nuclear transport.

1995 • 144 citations

CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae.

1993 • 138 citations

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

1996 • 137 citations

Ran-binding Protein 1 (RanBP1) Forms a Ternary Complex with Ran and Karyopherin β and Reduces Ran GTPase-activating Protein (RanGAP) Inhibition by Karyopherin β

1997 • 134 citations

The C Terminus of the Nuclear RAN/TC4 GTPase Stabilizes the GDP-bound State and Mediates Interactions with RCC1, RAN-GAP, and HTF9A/RANBP1

1995 • 133 citations

RNA1 Encodes a GTPase-activating Protein Specific for Gsp1p, the Ran/TC4 Homologue of Saccharomyces cerevisiae

1995 • 129 citations

Human RanGTPase activating protein RanGAP1 is a homolog of yeast RNA1p involved in messenger RNA processing and transport

1995 • 125 citations

Separate Binding Sites on Nuclear Transport Factor 2 (NTF2) for GDP-Ran and the Phenylalanine-rich Repeat Regions of Nucleoporins p62 and Nsp1p

1996 • 122 citations

RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.

1996 • 118 citations

Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis

1998 • 113 citations

The NTF2 Gene Encodes an Essential, Highly Conserved Protein That Functions in Nuclear Transport in Vivo

1996 • 102 citations

Interaction between the Small GTPase Ran/Gsp1p and Ntf2p Is Required for Nuclear Transport

1997 • 98 citations

A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.

1993 • 93 citations

Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.

1996 • 80 citations

Functions of the GTPase Ran in RNA export from the nucleus

1998 • 80 citations

Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran

1997 • 71 citations

Molecular interactions between the importin α/β heterodimer and proteins involved in vertebrate nuclear protein import

1997 • 70 citations

The nuclear import factor p10 regulates the functional size of the nuclear pore complex during oogenesis

1998 • 56 citations

High Levels of the GTPase Ran/TC4 Relieve the Requirement for Nuclear Protein Transport Factor 2

1997 • 41 citations

CSE1 and CSE2, Two New Genes Required for Accurate Mitotic Chromosome Segregation in Saccharomyces cerevisiae

1993 • 41 citations

Crystallization and Preliminary X-Ray Diffraction Analysis of Nuclear Transport Factor 2

1996 • 28 citations