Importin β Can Mediate the Nuclear Import of an Arginine-Rich Nuclear Localization Signal in the Absence of Importin α

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Sequence requirements for nuclear location of simian virus 40 large-T antigen

1984 • 1,278 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α

1998 • 759 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

THE HIV-1 REV PROTEIN

1998 • 716 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Identification of different roles for RanGDP and RanGTP in nuclear protein import.

1996 • 644 citations

The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1997 • 628 citations

Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

1997 • 613 citations

A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

1995 • 529 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

Importin beta , transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

1998 • 524 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

A nuclear localization domain in the hnRNP A1 protein.

1995 • 510 citations

A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus.

1996 • 419 citations

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

1998 • 392 citations

The Arginine-Rich Domains Present in Human Immunodeficiency Virus Type 1 Tat and Rev Function as Direct Importin β-Dependent Nuclear Localization Signals

1999 • 384 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

Identification of a tRNA-Specific Nuclear Export Receptor

1998 • 379 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

1997 • 371 citations

Nucleocytoplasmic Transport: The Last 200 Nanometers

1998 • 361 citations

Protein Sequence Requirements for Function of the Human T-Cell Leukemia Virus Type 1 Rex Nuclear Export Signal Delineated by a Novel In Vivo Randomization-Selection Assay

1996 • 356 citations

Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1

1995 • 334 citations

HIV-1 Auxiliary Proteins: Making Connections in a Dying Cell

1998 • 328 citations

Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

1988 • 308 citations

The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.

1994 • 305 citations

Mechanism of action of regulatory proteins encoded by complex retroviruses

1992 • 299 citations

Nuclear protein import

1997 • 296 citations

Identification of a nuclear export receptor for tRNA

1998 • 286 citations

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure

1998 • 276 citations

Sequence and characterization of cytoplasmic nuclear protein import factor p97.

1995 • 274 citations

Interactions between HIV rev and nuclear import and export factors: the rev nuclear localisation signal mediates specific binding to human importin-β

1997 • 255 citations

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

1996 • 252 citations

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins

1997 • 252 citations

From nucleoporins to nuclear pore complexes

1997 • 243 citations

Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein

1988 • 216 citations

Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins

1995 • 211 citations

Requirement of Guanosine Triphosphate-Bound Ran for Signal-Mediated Nuclear Protein Export

1997 • 183 citations

Karyopherin β2 mediates nuclear import of a mRNA binding protein

1997 • 160 citations

Nucleo-cytoplasmic distribution of human hnrnp proteins: a search for the targeting domains in hnrnp a1

1995 • 158 citations

Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif

1991 • 147 citations

Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β

1997 • 146 citations

Inhibition of nuclear accumulation of karyophilic proteins in living cells by microinjection of the lectin wheat germ agglutinin

1988 • 146 citations

Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport.

1991 • 144 citations

Nuclear import of U snRNPs requires importin beta

1997 • 141 citations

Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

1996 • 137 citations

The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.

1994 • 136 citations

Functional similarity of HIV-I rev and HTLV-I rex proteins: Identification of a new nucleolar-targeting signal in rev protein

1989 • 131 citations

Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals

1996 • 119 citations

Association of the T-cell Protein Tyrosine Phosphatase with Nuclear Import Factor p97

1997 • 118 citations

Analysis of Trafficking of Rev and Transdominant Rev Proteins in Living Cells Using Green Fluorescent Protein Fusions: Transdominant Rev Blocks the Export of Rev from the Nucleus to the Cytoplasm1

1995 • 114 citations

Structural and functional characterization of the human immunodeficiency virus rev protein.

1989 • 100 citations

Characterization of the Nuclear Export Signal of Human T-Cell Lymphotropic Virus Type 1 Rex Reveals that Nuclear Export Is Mediated by Position-Variable Hydrophobic Interactions

1996 • 96 citations

Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways.

1992 • 93 citations

HIV-1 Rev Is Capable of Shuttling between the Nucleus and Cytoplasm

1994 • 84 citations

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.

1991 • 83 citations

Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange

1992 • 75 citations

Trans-dominant inactivation of HTLV-I and HIV-1 gene expression by mutation of the HTLV-I Rex transactivator

1989 • 73 citations

The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal

1996 • 67 citations

RanGTP-mediated nuclear export of karyopherin α involves its interaction with the nucleoporin Nup153

1997 • 65 citations

Identification and Functional Characterization of a Novel Nuclear Localization Signal Present in the Yeast Nab2 Poly(A)⁺ RNA Binding Protein

1998 • 63 citations

Nucleocytoplasmic Transport of the Rev Protein of Human Immunodeficiency Virus Type 1 Is Dependent on the Activation Domain of the Protein

1995 • 63 citations

Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms

1998 • 57 citations

The Human Immunodeficiency Virus Type 1 Rev Protein Shuttles between the Cytoplasm and Nuclear Compartments

1994 • 51 citations

Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function

1991 • 43 citations

Signal-mediated nuclear export pathways of proteins and RNAs

1996 • 33 citations