Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Gain of function mutations in p53

1993 • 876 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

1994 • 283 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

Mapping of the p53 and mdm-2 Interaction Domains

1993 • 241 citations

Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

1993 • 193 citations

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.

1994 • 151 citations

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest.

1992 • 123 citations

The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

1993 • 120 citations

Analysis of p53 mutants for transcriptional activity.

1991 • 106 citations

The mdm-2 Oncogene Can Overcome Wild-Type p53 Suppression of Transformed Cell Growth

1993 • 84 citations

Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53.

1993 • 42 citations

Analysis of p53 Mutants for Transcriptional Activity

1991 • 31 citations