The Carboxyl Terminus of Interferon-γ Contains a Functional Polybasic Nuclear Localization Sequence

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

1997 • 362 citations

Regulation of STAT‐dependent pathways by growth factors and cytokines

1996 • 297 citations

Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling?

1998 • 161 citations

Identification of a nuclear localization sequence within the structure of the human interleukin-1 alpha precursor.

1993 • 154 citations

[11] Nuclear protein import using digitonin-permeabilized cells

1992 • 138 citations

Nuclear signaling pathways for polypeptide ligands and their membrane receptors?

1994 • 133 citations

Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4

1996 • 112 citations

Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-gamma encapsulated in liposomes.

1985 • 95 citations

Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells.

1987 • 74 citations

Nuclear accumulation of interferon gamma.

1994 • 69 citations

The carboxyl-terminal region of human interferon γ is important for biological activity: mutagenic and NMR analysis

1991 • 66 citations

Role of polycationic C-terminal portion in the structure and activity of recombinant human interferon-gamma.

1986 • 63 citations

Role of the carboxy-terminal sequence on the biological activity of human immune interferon (IFN-γ)

1988 • 57 citations

The C-Terminus of IFN-γ Is Sufficient for Intracellular Function

1994 • 57 citations

The cytokine interleukin‐5 (IL‐5) effects cotransport of its receptor subunits to the nucleus in vitro

1997 • 53 citations

Cytokine-Receptor Complexes as Chaperones for Nuclear Translocation of Signal Transducers

1998 • 50 citations

Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages.

1990 • 48 citations

A functional bipartite nuclear localisation signal in the cytokine interleukin‐5

1997 • 41 citations

Binding of IFNγ and Its C-Terminal Peptide to a Cytoplasmic Domain of Its Receptor That Is Essential for Function

1994 • 38 citations

Transport of γ-interferon into the cell nucleus may be mediated by nuclear membrane receptors

1986 • 36 citations

Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133).

1995 • 33 citations

Carboxy‐terminal truncated rhuIFN‐γ with a substitution of Gln133 or Ser132 to leucine leads to higher biological activity than in the wild type

1991 • 30 citations

Structural Requirements for Agonist Activity of a Murine Interferon-γ Peptide

1996 • 27 citations

Mutational analysis of the C-terminus of human interferon-γ

1990 • 26 citations

Human IFNγ Receptor Cytoplasmic Domain: Expression and Interaction with HuIFNγ

1998 • 18 citations

Expression of Intracellular Interferon Constitutively Activates ISGF3 and Confers Resistance to EMC Viral Infection

1996 • 15 citations

The cellular internalization of recombinant gamma interferon differs from that of natural interferon gamma

1988 • 6 citations