Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

1997 • 2,062 citations

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

1997 • 1,195 citations

NUCLEOCYTOPLASMIC TRANSPORT: The Soluble Phase

1998 • 1,184 citations

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor

1997 • 1,144 citations

Leptomycin B Inhibition of Signal-Mediated Nuclear Export by Direct Binding to CRM1

1998 • 801 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export

1997 • 716 citations

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

1997 • 654 citations

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1997 • 480 citations

Distinct functions for the two importin subunits in nuclear protein import

1995 • 479 citations

The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65

1998 • 462 citations

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

1994 • 453 citations

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

1997 • 435 citations

A Novel Class of RanGTP Binding Proteins

1997 • 427 citations

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1

1998 • 304 citations

Experiments with fission yeast: A laboratory course manual

1994 • 290 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

1995 • 264 citations

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery.

1989 • 246 citations

Transport routes through the nuclear pore complex

1998 • 240 citations

The Specificity of the CRM1-Rev Nuclear Export Signal Interaction Is Mediated by RanGTP

1998 • 221 citations

Molecular Cloning and Cell Cycle-dependent Expression of Mammalian CRM1, a Protein Involved in Nuclear Export of Proteins

1997 • 212 citations

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.

1983 • 160 citations

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1

1999 • 141 citations

Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells

1990 • 123 citations

Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1.

1992 • 116 citations

Caffeine-resistance in fission yeast is caused by mutations in a single essential gene,crm1 +

1996 • 51 citations

A cytosolic activity distinct from Crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells

1998 • 48 citations

Fission Yeast pap1-Dependent Transcription Is Negatively Regulated by an Essential Nuclear Protein, crml

1992 • 32 citations