The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel

1994 • 450 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3

1989 • 252 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

G protein beta gamma subunits. Simplified purification and properties of novel isoforms.

1994 • 178 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions

1994 • 168 citations

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

1992 • 129 citations

A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-beta.

1996 • 73 citations

Subunit composition of G(o) proteins functionally coupling galanin receptors to voltage-gated calcium channels.

1995 • 73 citations

[25] Identification of receptor-activated G proteins with photoreactive GTP analog, [α-32P]GTP azidoanilide

1991 • 70 citations

Identification and characterization of a lysophosphatidic acid receptor.

1994 • 64 citations

G12 and G13 α-Subunits Are Immunochemically Detectable in Most Membranes of Various Mammalian Cells and Tissues

1994 • 64 citations

Inhibition of GTP-utilizing enzymes by tyrphostins.

1994 • 37 citations

Interaction of G protein Gβγ dimers with small GTP‐binding proteins of the Rho family

1996 • 32 citations

Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of Gα12 purified from rat brain

1996 • 16 citations

Purification of the G-protein G13 from rat brain membranes

1994 • 15 citations