Interaction with Gβγ Is Required for Membrane Targeting and Palmitoylation of Gαs and Gαq

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G _sα ·GTPγS

1997 • 780 citations

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 • 663 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

1990 • 463 citations

GENETIC AND BIOCHEMICAL STUDIES OF PROTEIN N-MYRISTOYLATION

1994 • 403 citations

Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.

1994 • 351 citations

Myristoylation

1997 • 350 citations

Membrane organization in G‐protein mechanisms

1994 • 345 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

1983 • 331 citations

Signalling functions of protein palmitoylation

1998 • 328 citations

Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes

1995 • 294 citations

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

1993 • 293 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits

1993 • 262 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Receptor regulation of G-protein palmitoylation.

1994 • 229 citations

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

1990 • 225 citations

Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins

1996 • 217 citations

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.

1992 • 205 citations

Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization

1994 • 205 citations

Identification of effector-activating residues of Gsα

1992 • 180 citations

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

1993 • 180 citations

G-protein Palmitoyltransferase Activity Is Enriched in Plasma Membranes

1996 • 170 citations

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

1994 • 165 citations

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.

1997 • 160 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

A novel N-terminal motif for palmitoylation of G-protein α subunits

1993 • 156 citations

Functional Importance of the Amino Terminus of Gqα

1996 • 143 citations

Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif

1997 • 136 citations

Gonadotropin-Releasing Hormone Receptor Couples to Multiple G Proteins in Rat Gonadotrophs and in GGH3 Cells: Evidence from Palmitoylation and Overexpression of G proteins1

1998 • 118 citations

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.

1994 • 111 citations

Plasma Membrane Localization of Gα_zRequires Two Signals

1998 • 94 citations

Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells.

1995 • 93 citations

Structural analysis of rod GTP-binding protein, Gt. Limited proteolytic digestion pattern of Gt with four proteases defines monoclonal antibody epitope

1991 • 93 citations

Fatty Acylation of α2

1995 • 90 citations

Regulation of Gq/11α by the Gonadotropin-Releasing Hormone Receptor

1997 • 88 citations

Persistent membrane association of activated and depalmitoylated G protein α subunits

1999 • 87 citations

Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.

1992 • 75 citations

Lipid Modifications and Membrane Targeting of G<sub>α</sub>

1998 • 73 citations

Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells.

1996 • 71 citations

G ProteinsTechniques of Analysis

1999 • 69 citations

Gβγ and Palmitate Target Newly Synthesized Gαzto the Plasma Membrane

1999 • 63 citations

A Non-farnesylated Ha-Ras Protein Can Be Palmitoylated and Trigger Potent Differentiation and Transformation

1999 • 63 citations

Characterization of interactions between transducin alpha/beta gamma-subunits and lipid membranes.

1994 • 60 citations

Failure to myristoylate the alpha subunit of Gz is correlated with an inhibition of palmitoylation and membrane attachment, but has no affect on phosphorylation by protein kinase C.

1994 • 56 citations

N-terminal fatty acylation of the α-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation

1994 • 49 citations

Identification of Common and Distinct Residues Involved in the Interaction of αi2 and αs with Adenylyl Cyclase

1997 • 44 citations

Gα₁₂ Requires Acylation for Its Transforming Activity

1998 • 39 citations

G _sα contains an unidentified covalent modification that increases its affinity for adenylyl cyclase

1997 • 38 citations

The palmitoylation status of the G-protein Go1 α regulates its activity of interaction with the plasma membrane

1994 • 38 citations

Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli.

1993 • 37 citations

A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding.

1992 • 33 citations

Effect of monoclonal antibody binding on .alpha.-.beta..gamma. subunit interactions in the rod outer segment G protein, Gt

1989 • 26 citations

Serotonin-mediated palmitoylation and depalmitoylation of G alpha proteins in rat brain cortical membranes.

1998 • 23 citations

N-terminal domain of Gpa1 (G protein α subunit) is sufficient for plasma membrane targeting in yeast Saccharomyces cerevisiae

1998 • 20 citations

Interaction of the G‐protein G₁₁α with receptors and phosphoinositidase C:

1997 • 20 citations

Analysis of the N-terminal binding domain of Goα

1997 • 16 citations