Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

A review of central 5-HT receptors and their function

1999 • 3,121 citations

The Mesolimbic Dopamine Reward Circuit in Depression

2006 • 1,931 citations

Brain Dopamine and Reward

1989 • 1,899 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

1985 • 1,855 citations

Molecular, pharmacological and functional diversity of 5-HT receptors

2002 • 1,822 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

1989 • 1,107 citations

Selective activation of the mesocortical DA system by stress

1976 • 1,037 citations

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

1997 • 985 citations

Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action

1998 • 875 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

1994 • 861 citations

Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

1992 • 832 citations

Supranormal Stimulation of D₁Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance

1997 • 805 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

1985 • 803 citations

Serotonin receptors : their key role in drugs to treat schizophrenia

2003 • 759 citations

Increased dopamine transmission in schizophrenia: relationship to illness phases

1999 • 713 citations

Neurotransmitter regulation of dopamine neurons in the ventral tegmental area

1993 • 713 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding

1992 • 681 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

1993 • 607 citations

5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex

1991 • 599 citations

Noise Stress Impairs Prefrontal Cortical Cognitive Function in Monkeys

1998 • 585 citations

Comparative localization of serotonin_{1A, 1C}, and ₂ receptor subtype mRNAs in rat brain

1995 • 549 citations

Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of [3h]5-hydroxytryptamine

1981 • 527 citations

SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

1997 • 519 citations

5-Hydroxytryptamine _2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

1998 • 510 citations

Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate‐treated rats

1997 • 501 citations

Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat

1999 • 498 citations

5‐HT_2A and D₂ receptor blockade increases cortical DA release via 5‐HT_1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release

2001 • 491 citations

Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells

1997 • 487 citations

Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain

2000 • 472 citations

Expression of Serotonin1A and Serotonin2A Receptors in Pyramidal and GABAergic Neurons of the Rat Prefrontal Cortex

2004 • 463 citations

Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons

1987 • 374 citations

Altered Editing of Serotonin 2C Receptor Pre-mRNA in the Prefrontal Cortex of Depressed Suicide Victims

2002 • 370 citations

Nervous system distribution of the serotonin 5-HT3 receptor mRNA.

1993 • 369 citations

Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS

2000 • 367 citations

The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals

1994 • 346 citations

Localization of 5-HT1B, 5-HT1Dα, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain

1994 • 343 citations

Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat

2000 • 333 citations

Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex

1997 • 324 citations

Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system

1997 • 317 citations

Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

2001 • 317 citations

Cellular localization of the 5-HT receptor in primate brain neurons and glial cells

1996 • 304 citations

Constitutive Activity of the Serotonin2C Receptor InhibitsIn VivoDopamine Release in the Rat Striatum and Nucleus Accumbens

2004 • 301 citations

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

1992 • 293 citations

Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors.

2000 • 290 citations

Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors.

2000 • 286 citations

Involvement of 5-HT_1AReceptors in Prefrontal Cortex in the Modulation of Dopaminergic Activity: Role in Atypical Antipsychotic Action

2005 • 280 citations

Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

1998 • 278 citations

5-HT Modulation of Dopamine Release in Basal Ganglia in Psilocybin-Induced Psychosis in Man—A PET Study with [11C]raclopride

1999 • 277 citations

Serotonin 5-HT2C Receptors as a Target for the Treatment of Depressive and Anxious States: Focus on Novel Therapeutic Strategies

2005 • 276 citations

5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line

1988 • 261 citations

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

1989 • 258 citations

Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis

1993 • 256 citations

The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat

1990 • 254 citations

RNA Editing of the Human Serotonin 5-HT2C Receptor Alterations in Suicide and Implications for Serotonergic Pharmacotherapy

2001 • 249 citations

5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons

1992 • 247 citations

Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

2002 • 247 citations

SB 242 084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system

1999 • 244 citations

Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats

1997 • 240 citations

Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera

1995 • 240 citations

In vitro and in vivo profile of SB 206553, a potent 5‐HT_2C/5‐HT_2B receptor antagonist with anxiolytic‐like properties

1996 • 239 citations

Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.

1989 • 238 citations

Facilitation of dopamine release in vivo by serotonin agonists: studies with microdialysis

1991 • 235 citations

The 5-HT6 Receptor Antagonist SB-271046 Selectively Enhances Excitatory Neurotransmission in the Rat Frontal Cortex and Hippocampus

2001 • 233 citations

Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain

1993 • 232 citations

Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

2000 • 231 citations

Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species

1989 • 230 citations

Serotonin-facilitated dopamine release in vivo: pharmacological characterization.

1993 • 230 citations

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

1991 • 225 citations

Functional hyperdopaminergia in dopamine transporter knock-out mice

1999 • 225 citations

5-HT6 receptors: a novel target for cognitive enhancement

2005 • 223 citations

Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study

1999 • 220 citations

Iontophoretically administered drugs acting at the N‐methyl‐D‐aspartate receptor modulate burst firing in A9 dopamine neurons in the rat

1992 • 219 citations

Cellular and subcellular localization of 5-hydroxytryptamine1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies

1999 • 218 citations

Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes.

1989 • 216 citations

5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum

2002 • 213 citations

Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways

1976 • 213 citations

Multiple Serotonin Receptors: Clinical and Experimental Aspects

1994 • 212 citations

Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo.

1994 • 210 citations

Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons.

1991 • 210 citations

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

2000 • 209 citations

Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex

2003 • 209 citations

Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system

1997 • 206 citations

The activation of 5‐HT_2A receptors in prefrontal cortex enhances dopaminergic activity

2005 • 203 citations

Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

1991 • 201 citations

Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation

1997 • 201 citations

Localization of 5-HT7 receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression

2001 • 200 citations

5-HT1A receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex

2000 • 200 citations

Distribution of neurons expressing immunoreactivity for the 5HT3 receptor subtype in the rat brain and spinal cord

1998 • 193 citations

Cocaine inhibits GABA release in the VTA through endogenous 5-HT

1994 • 191 citations

Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats

1996 • 191 citations

5-hydroxytryptamine2A receptor inverse agonists as antipsychotics.

2001 • 190 citations

Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex

2005 • 188 citations

Dissociable Contribution of 5-HT1A and 5-HT2A Receptors in the Medial Prefrontal Cortex to Different Aspects of Executive Control such as Impulsivity and Compulsive Perseveration in Rats

2005 • 182 citations

Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin2C receptors

2000 • 179 citations

Differential effects of acute and chronic fluoxetine administration on the spontaneous activity of dopaminergic neurones in the ventral tegmental area

1995 • 179 citations

Blockage of 5HT_2Cserotonin receptors by fluoxetine (Prozac)

1997 • 178 citations

Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: a combined in vivo electrophysiological and microdialysis study

2000 • 175 citations

Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens

2001 • 174 citations

Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area

2000 • 173 citations

Serotonin_1BReceptor Stimulation Enhances Cocaine Reinforcement

1998 • 172 citations

Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats

1999 • 171 citations

Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons.

1990 • 170 citations

Localization of 5-HT2A receptors on dopamine cells in subnuclei of the midbrain A10 cell group

2002 • 169 citations

The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor.

1992 • 167 citations

Role of Striatal Serotonin_2A and Serotonin_2C Receptor Subtypes in the Control of In Vivo Dopamine Outflow in the Rat Striatum

2000 • 165 citations

Modulation of dopamine release by striatal 5‐HT2C receptors

2005 • 165 citations

Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra

1988 • 165 citations

Quantitative autoradiographic mapping of 5‐HT₃ receptors in the rat CNS using [¹²⁵I]iodo‐zacopride and [³H]zacopride as radioligands

1992 • 165 citations

The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons

1993 • 165 citations

The 5-HT7 receptor: orphan found

1997 • 164 citations

Activation of a 5-HT3 receptor releases dopamine from rat striatal slice

1988 • 163 citations

Distribution of serotonin 5‐HT_1C receptor mRNA in adult rat brain

1989 • 161 citations

5‐HT_2A and α1b‐adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants

2004 • 160 citations

5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra

1988 • 160 citations

The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study

1990 • 160 citations

Role of Serotonin_2A and Serotonin_2B/2C Receptor Subtypes in the Control of Accumbal and Striatal Dopamine Release Elicited In Vivo by Dorsal Raphe Nucleus Electrical Stimulation

1999 • 160 citations

Effects of 5, 7-dihydroxytryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography

1987 • 155 citations

Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse

2006 • 154 citations

5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats

1989 • 153 citations

Enhanced Locomotor, Reinforcing, and Neurochemical Effects of Cocaine in Serotonin 5-Hydroxytryptamine 2C Receptor Mutant Mice

2002 • 152 citations

Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain

1999 • 152 citations

Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens

1995 • 150 citations

Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.

1995 • 148 citations

Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.

1988 • 145 citations

Serotonergic involvement in haloperidol-induced catalepsy.

1993 • 144 citations

Opposite change of in vivo dopamine release in the rat nucleus accumbens and striatum that follows electrical stimulation of dorsal raphe nucleus: role of 5-HT3 receptors.

1998 • 143 citations

The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus

1996 • 143 citations

Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine

1990 • 142 citations

5‐HT₆ receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

2003 • 142 citations

LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.

1996 • 140 citations

Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro

1994 • 138 citations

Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rat

1995 • 136 citations

Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization.

1996 • 134 citations

Tonic GABA-ergic modulation of striatal dopamine release studied by in vivo microdialysis in the freely moving rat

1995 • 133 citations

5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner

2002 • 133 citations

Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration

2003 • 130 citations

Serotonin 5‐HT₄ receptors and their mRNAs in rat and guinea pig brain: Distribution and effects of neurotoxic lesions

2005 • 129 citations

Blockade of Striatal 5‐Hydroxytryptmine₂ Receptors Reduces the Increase in Extracellullar Concentrations of Dopamine Produced by the Amphhetamine analogue 3,4‐Methylenedioxymethamphetamine

1994 • 129 citations

Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat

1992 • 129 citations

Characterisation and autoradiographic localisation of 5-HT3 receptor recognition sites identified with [3H]-(S)-zacopride in the forebrain of the rat

1990 • 128 citations

M100,907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex

2001 • 128 citations

Contrasting Contribution of 5-Hydroxytryptamine 1A Receptor Activation to Neurochemical Profile of Novel Antipsychotics: Frontocortical Dopamine and Hippocampal Serotonin Release in Rat Brain

2005 • 127 citations

Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function

1993 • 125 citations

Contribution of Serotonin (5-Hydroxytryptamine; 5-HT) 5-HT₂ Receptor Subtypes to the Hyperlocomotor Effects of Cocaine: Acute and Chronic Pharmacological Analyses

2004 • 124 citations

m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors

2001 • 124 citations

Serotonin-3 receptor and ethanol-stimulated somatodendritic dopamine release

1996 • 122 citations

Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum

2001 • 119 citations

Localization of 5-HT3 receptors in the rat brain using [3H]LY278584

1991 • 117 citations

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

1996 • 117 citations

Lesion Study of the Distribution of Serotonin 5‐HT₄ Receptors in Rat Basal Ganglia and Hippocampus

1996 • 116 citations

The effect of serotonin1A receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens

2000 • 115 citations

Localization of 5-HT2A Receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken

1998 • 115 citations

Elevated Expression of 5-HT_1BReceptors in Nucleus Accumbens Efferents Sensitizes Animals to Cocaine

2002 • 113 citations

Opposite Change ofIn VivoDopamine Release in the Rat Nucleus Accumbens and Striatum That Follows Electrical Stimulation of Dorsal Raphe Nucleus: Role of 5-HT₃Receptors

1998 • 108 citations

Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: enhancement of antipsychotic-like effects without catalepsy

1991 • 106 citations

Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors

2005 • 105 citations

Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment

2004 • 104 citations

Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin_2C(5-HT_2C) Receptors in Rat Prefrontal Cortex

2003 • 104 citations

Selective blockade of serotonin2C/2B receptors enhances dopamine release in the rat nucleus accumbens

1998 • 104 citations

Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex

2001 • 103 citations

8-OH-DPAT, a 5-HT 1A agonist and ritanserin, a 5-HT 2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release

1997 • 103 citations

Evidence for the presence of N-methyl-d-aspartate receptors in the ventral tegmental area of the rat: an electrophysiological in vitro study

1990 • 103 citations

5-HT5 Receptors

2004 • 102 citations

Modulation of the discriminative stimulus properties of cocaine by 5-HT1B and 5-HT2C receptors.

1995 • 102 citations

(R)‐8‐OH‐DPAT preferentially increases dopamine release in rat medial prefrontal cortex

1993 • 102 citations

Serotonin_1BReceptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels

2004 • 99 citations

Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535

1998 • 99 citations

5-HT3 receptor antagonists block morphine- and nicotine-induced place-preference conditioning

1988 • 98 citations

High Calcium Permeability of Serotonin 5‐HT₃ Receptors on Presynaptic Nerve Terminals from Rat Striatum

1998 • 96 citations

In Vivo Evidence that 5-HT2C Receptor Antagonist but not Agonist Modulates Cocaine-Induced Dopamine Outflow in the Rat Nucleus Accumbens and Striatum

2003 • 95 citations

Activation of 5-HT1B/1D receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study

2001 • 95 citations

5-HT6 receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine

2002 • 95 citations

The Selective Serotonin-2A Receptor Antagonist M100907 Reverses Behavioral Deficits in Dopamine Transporter Knockout Mice

2003 • 94 citations

Stimulation of 5‐hydroxytryptamine (5‐HT_2C) receptors in the ventrotegmental area inhibits stress‐induced but not basal dopamine release in the rat prefrontal cortex

2002 • 94 citations

Excitation of rat substantia nigra pars reticulata neurons by 5-hydroxytryptaminein vitro: Evidence for a direct action mediated by 5-hydroxytryptamine2C receptors

1995 • 92 citations

Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons

1989 • 91 citations

Localization of serotonin-4 receptors in the striatonigral pathway in rat brain

1995 • 86 citations

Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning

1992 • 86 citations

Serotonin-stimulated release of [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens: a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine.

1992 • 86 citations

Serotonin-1 receptor binding sites in the human basal ganglia are decreased in huntington's chorea but not in parkinson's disease: A quantitative in vitro autoradiography study

1989 • 85 citations

DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum

1995 • 84 citations

RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine

1999 • 84 citations

Presynaptic dopamine release is enhanced by 5‐HT₃ receptor activation in medial prefrontal cortex of freely moving rats

1992 • 84 citations

Serotonin–GABA interactions modulate MDMA‐induced mesolimbic dopamine release

2004 • 83 citations

Autoradiographic distribution of [ 3 H]-(S)-zacopride-labelled 5-HT 3 receptors in human brain

1996 • 82 citations

5-HT1D receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra

1988 • 81 citations

Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: Effect of 5,7-dihydroxytryptamine

1997 • 81 citations

5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat

1993 • 81 citations

Behavioral Effects of 5-HT2CReceptor Antagonism in the Substantia Nigra Zona Reticulata of the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

1998 • 80 citations

SR46349-B, a 5-HT2A/2C Receptor Antagonist, Potentiates Haloperidol-induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens

2002 • 77 citations

Selective stimulation of serotonin_2C receptors blocks the enhancement of striatal and accumbal dopamine release induced by nicotine administration

2004 • 77 citations

The 5-Hydroxytryptamine₆Receptor-Selective radioligand [³H]Ro 63–0563 Labels 5-Hydroxytryptamine Receptor Binding Sites in Rat and Porcine Striatum

1998 • 77 citations

R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum.

1999 • 76 citations

Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT2C/2B receptor antagonists: neurochemical and behavioural studies

2000 • 75 citations

Serotonin 5-HT2C agonists selectively inhibit morphine-induced dopamine efflux in the nucleus accumbens

1998 • 74 citations

The 5-HT1A receptor and behavioral stimulation in the rat: effects of 8-OHDPAT on spontaneous and cocaine-induced behavior

2004 • 73 citations

Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis

2004 • 73 citations

Modulation of the Discriminative Stimulus Properties of Cocaine: Comparison of the Effects of Fluoxetine with 5-HT1A and 5-HT1B Receptor Agonists

1997 • 72 citations

Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase

1992 • 72 citations

5-HT3-like receptors in the rat medial prefrontal cortex: an electrophysiological study

1991 • 70 citations

Serotonin_1AReceptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia

2004 • 70 citations

Ability of 5‐HT₄ receptor ligands to modulate rat striatal dopamine release in vitro and in vivo

1996 • 69 citations

Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells.

1995 • 69 citations

Agonist‐Induced Phosphoinositide Hydrolysis in Choroid Plexus

1986 • 69 citations

The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity.

2000 • 68 citations

Local 5HT3 receptors mediate fluoxetine but not desipramine-induced increase of extracellular dopamine in the prefrontal cortex

1995 • 66 citations

Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner

2004 • 66 citations

Local infusion of the selective 5HT‐1B agonist CP‐93,129 facilitates striatal dopamine release in vivo

1993 • 66 citations

Local infusion of the serotonin antagonists ritanserin or ICS 205,930 increases in vivo dopamine release in the rat medial prefrontal cortex

1996 • 66 citations

5-Hydroxytryptamine and 5-hydroxytryptaminergic-dopaminergic interactions in the ventral tegmental area of rat brain

1982 • 65 citations

Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex

1999 • 64 citations

Distribution of serotonin 5-HT2A receptors in afferents of the rat striatum

2001 • 64 citations

Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors

1999 • 64 citations

5-HT 3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat

2002 • 62 citations

Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats

2005 • 61 citations

S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol.

1998 • 61 citations

Targeting of serotonin 1a receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain

2001 • 61 citations

Serotonin 5‐HT₂ Receptor Stimulation of Dopamine Release in the Posterior but Not Anterior Nucleus Accumbens of the Rat

2000 • 60 citations

Conditional involvement of striatal serotonin₃ receptors in the control of in vivo dopamine outflow in the rat striatum

2003 • 59 citations

Serotonin Stimulation of 5‐HT₄ Receptors Indirectly Enhances In Vivo Dopamine Release in the Rat Striatum

1997 • 59 citations

The 5-HT3 receptor antagonist zatosetron decreases the number of spontaneously active A10 dopamine neurons

1991 • 58 citations

5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes

1999 • 57 citations

The putative 5-HT3 agonist phenylbiguanide induces carrier-mediated release of [3H]dopamine

1989 • 57 citations

Atypical antipsychotics in bipolar depression: Neurobiological basis and clinical implications

2006 • 56 citations

Nicotinic receptors co-localize with 5-HT3 serotonin receptors on striatal nerve terminals

2000 • 55 citations

Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats

2003 • 55 citations

Stimulation of serotonin 1B receptors induces conditioned place aversion and facilitates cocaine place conditioning in rats

2002 • 53 citations

Stimulation of Serotonin_2CReceptors Blocks the Hyperactivation of Midbrain Dopamine Neurons Induced by Nicotine Administration

2004 • 53 citations

Decreased Neuroendocrine Responses to Meta-Chlorophenylpiperazine (m-CPP) but Normal Responses to Ipsapirone in Marathon Runners

1999 • 52 citations

Alterations in Extracellular and Tissue Levels of Biogenic Amines in Rat Brain Induced by the Serotonin₂ Receptor Antagonist, Ritanserin

1992 • 51 citations

Neurochemical and electrophysiological evidence that 5‐HT₄ receptors exert a state‐dependent facilitatory control in vivo on nigrostriatal, but not mesoaccumbal, dopaminergic function

2001 • 51 citations

Serotonin‐1B receptor‐mediated inhibition of [³H]GABA release from rat ventral tegmental area slices

2001 • 50 citations

Regionally and functionally distinct serotonin₃ receptors control in vivo dopamine outflow in the rat nucleus accumbens

2005 • 50 citations

The 5-HT3 antagonist zacopride attenuates cocaine-induced increases in extracellular dopamine in rat nucleus accumbens

1993 • 49 citations

Characterization of 5-hydroxytryptamine3 receptors in the medial prefrontal cortex: a microiontophoretic study

1989 • 48 citations

Influence of 5-HT1B/1D receptors on dopamine release in the guinea pig nucleus accumbens: a microdialysis study

1997 • 48 citations

Central serotonin4 receptors selectively regulate the impulse-dependent exocytosis of dopamine in the rat striatum: in vivo studies with morphine, amphetamine and cocaine

2002 • 48 citations

Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys

2004 • 48 citations

Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell.

1999 • 47 citations

5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes: further evidence using 5-HT moduline, polyclonal 5-HT1B receptor antibodies and 5-HT1B receptor knock-out mice

2000 • 47 citations

5-HT4 receptor involvement in the serotonin-enhanced dopamine efflux from the substantia nigra of the freely moving rat: a microdialysis study

1998 • 47 citations

5-HT2C receptor antagonists enhance the behavioural response to dopamine D1 receptor agonists in the 6-hydroxydopamine-lesioned rat

2000 • 45 citations

Role of 5‐HT₃ receptors in basal and K⁺‐evoked dopamine release from rat olfactory tubercle and striatal slices

1994 • 43 citations

Role of 5-HT2A and 5-HT2C/B receptors in the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on striatal single-unit activity and locomotion in freely moving rats

2005 • 43 citations

SSRI treatment decreases prolactin and hyperthermic responses to mCPP

1997 • 42 citations

Role and localization of serotonin2 (S2)-receptor-binding sites: effects of neuronal lesions.

1983 • 41 citations

Conditioned place preference for cocaine is attenuated in mice over-expressing the 5-HT 3 receptor

2001 • 41 citations

Differential regulation of somatodendritic and nerve terminal dopamine release by serotonergic innervation of substantia nigra

2003 • 39 citations

Dopamine releasing effect of phenylbiguanide in rat striatal slices

1992 • 39 citations

Rewarding effects elicited by cocaine microinjections into the ventral tegmental area of C57BL/6 mice: involvement of dopamine D1 and serotonin1B receptors

2004 • 38 citations

Dissociable Roles for the Dorsal and Median Raphé in the Facilitatory Effect of 5-HT1A Receptor Stimulation upon Cocaine-Induced Locomotion and Sensitization

2004 • 37 citations

Regional distribution of serotonin-2 receptor binding sites in the brain and effects of neuronal lesions.

1982 • 35 citations

Intranigral GR-113808, a selective 5-HT4 receptor antagonist, attenuates morphine-stimulated dopamine release in the rat striatum

1995 • 35 citations

Serotonin2C receptors (5-HT2CR) control expression of cocaine-induced conditioned hyperactivity

2005 • 33 citations

Neurochemistry and neuropharmacology of schizophrenia

1987 • 33 citations

Ritanserin, a 5-HT2A/2C antagonist, reverses direct dopamine agonist-induced inhibition of midbrain dopamine neurons.

1995 • 31 citations

Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice

2003 • 31 citations

5‐HT₃ receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo

1995 • 30 citations

Action of serotonin in the medial prefrontal cortex: Mediation by serotonin₃‐like receptors

1992 • 30 citations

Ritanserin administration potentiates amphetamine-stimulated dopamine release in the rat prefrontal cortex

1997 • 28 citations

Validation of a selective serotonin 5-HT2C receptor antibody for utilization in fluorescence immunohistochemistry studies

2005 • 27 citations

Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on cocaine discrimination in rats

2003 • 27 citations

Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: OPPOSING ROLES FOR DOPAMINE AND SEROTONIN AT PRESYNAPTIC RECEPTORS IN THE VENTRAL TEGMENTAL AREA

1995 • 27 citations

Effects of a 5-HT7 receptor antagonist DR4004 on the exploratory behavior in a novel environment and on brain monoamine dynamics in mice

2005 • 27 citations

Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons

1989 • 27 citations

m-Chlorophenylpiperazine (mCPP) Modulates the Discriminative Stimulus Effects of Cocaine Through Actions at the 5-HT₂C Receptor.

2004 • 26 citations

5-HT 3 receptor mediated dopamine release in the nucleus accumbens during withdrawal from continuous cocaine

1997 • 26 citations

Chronic treatment with DAU 6215, a new 5-HT3 receptor antagonist, causes a selective decrease in the number of spontaneously active dopaminergic neurons in the rat ventral tegmental area

1992 • 25 citations

Selective reduction of extracellular dopamine in the rat nucleus accumbens following chronic treatment with DAU 6215, a 5-HT3 receptor antagonist

1995 • 25 citations

5-HT3 agonist-induced dopamine overflow during withdrawal from continuous or intermittent cocaine administration

1995 • 16 citations

The 5-HT1A receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens

2005 • 16 citations

γ-Aminobutyric acid (GABAB) receptor-mediated inhibition of tyrosine hydroxylase activity in the striatum of rat

1991 • 15 citations

Blockade of accumbens 5-HT3 receptor down-regulation by ondansetron administered during continuous cocaine administration

1999 • 15 citations

Human serotonin_ receptors is encoded by a subfamily of two distinct genes : 5-HT_ and 5-HT_

1992 • 13 citations

Dopamine and Reward

2002 • 13 citations

Dopamine Transporter-Dependent and -Independent Endogenous Dopamine Release from Weaver Mouse Striatum In Vitro

1995 • 10 citations