5-HT6 receptors: a novel target for cognitive enhancement

Serotonin receptors : their key role in drugs to treat schizophrenia

2003 • 759 citations

Acetylcholine in mind: a neurotransmitter correlate of consciousness?

1999 • 750 citations

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1994 • 592 citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

1993 • 588 citations

A Novel Rat Serotonin (5-HT6) Receptor: Molecular Cloning, Localization and Stimulation of cAMP Accumulation

1993 • 407 citations

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression.

2004 • 394 citations

Stress, cognitive impairment and cell adhesion molecules

2004 • 370 citations

Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT₆ Serotonin Receptor

1996 • 370 citations

Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system

1997 • 317 citations

5-ht6 Receptors

2004 • 296 citations

Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders

2003 • 250 citations

Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.

1993 • 246 citations

The 5-HT6 Receptor Antagonist SB-271046 Selectively Enhances Excitatory Neurotransmission in the Rat Frontal Cortex and Hippocampus

2001 • 233 citations

Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling

2003 • 211 citations

A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze

2001 • 201 citations

Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum

1996 • 195 citations

5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation—an effect sensitive to NMDA receptor antagonism

2004 • 192 citations

Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats

1996 • 191 citations

Influence of the 5-HT₆Receptor on Acetylcholine Release in the Cortex: Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT₆Receptor Antagonist

2003 • 188 citations

Antibodies and Antisense Oligonucleotide for Probing the Distribution and Putative Functions of Central 5-HT6 Receptors

1999 • 186 citations

Characterization of Ro 04‐6790 and Ro 63‐0563: potent and selective antagonists at human and rat 5‐HT₆ receptors

1998 • 181 citations

Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides.

1995 • 177 citations

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT₆ Receptor Antagonist

1999 • 169 citations

Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant

2003 • 157 citations

5-HT 6 receptor antagonists enhance retention of a water maze task in the rat

2001 • 154 citations

2-Substituted Tryptamines: Agents with Selectivity for 5-HT₆Serotonin Receptors

2000 • 147 citations

Differential Involvement of 5-HT1B/1D and 5-HT6 Receptors in Cognitive and Non-cognitive Symptoms in Alzheimer's Disease

2003 • 144 citations

5‐HT₆ receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

2003 • 142 citations

Characterization of SB‐271046: A potent, selective and orally active 5‐HT₆ receptor antagonist

2000 • 137 citations

In vivo effects of the 5-HT₆ antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate

2000 • 128 citations

The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

2003 • 128 citations

Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro�04-6790

2003 • 123 citations

Effects of the 5-HT7 receptor antagonist SB-258741 in animal models for schizophrenia

2002 • 117 citations

DARPP-32 mediates serotonergic neurotransmission in the forebrain

2002 • 116 citations

Investigation of stretching behaviour induced by the selective 5‐HT₆ receptor antagonist, Ro 04–6790, in rats

1999 • 105 citations

Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop

2001 • 103 citations

An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning

2003 • 102 citations

Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus

1997 • 99 citations

5-HT6 receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine

2002 • 95 citations

5-ht₆ Receptors as Emerging Targets for Drug Discovery

2000 • 93 citations

Central distribution and function of 5-HT6 receptor subtype in the rat brain

1998 • 89 citations

Lack of association between the T→C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia

2001 • 86 citations

5‐HT₆ receptor binding sites in schizophrenia and following antipsychotic drug administration: Autoradiographic studies with [¹²⁵I]SB‐258585

2002 • 85 citations

The 5-Hydroxytryptamine₆Receptor-Selective radioligand [³H]Ro 63–0563 Labels 5-Hydroxytryptamine Receptor Binding Sites in Rat and Porcine Striatum

1998 • 77 citations

Role of amygdala oscillations in the consolidation of emotional memories

2003 • 75 citations

Investigation of the human serotonin 6 (5-HT6) receptor gene in bipolar affective disorder and schizophrenia

2000 • 74 citations

Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders

2003 • 66 citations

Increase of hippocampal acetylcholine turnover rate and the stretching-yawning syndrome elicited by alpha-MSH and ACTH

1978 • 61 citations

Effects of the 5-HT6 receptor antagonist, SB-271046, in animal models for schizophrenia

2002 • 59 citations

Association Study of the 5-HT<sub>6</sub> Receptor Polymorphism (C267T) and Symptomatology and Antidepressant Response in Major Depressive Disorders

2001 • 57 citations

An RT-PCR study of 5-HT6 and 5-HT7 receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia

2002 • 56 citations

Association study of sertonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior

1999 • 56 citations

Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease

1999 • 56 citations

Effects of altered 5-ht6 expression in the rat: functional studies using antisense oligonucleotides

1995 • 56 citations

Role of 5-HT6 receptors in memory formation

2001 • 54 citations

Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine6 receptors in rat nucleus accumbens by antisense oligonucleotides

1999 • 53 citations

List of Drugs in Development for Neurodegenerative Diseases

2004 • 53 citations

Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain

1999 • 52 citations

5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides

2001 • 44 citations

Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

2004 • 41 citations

Association study of the 5-HT6 receptor gene in schizophrenia

1999 • 41 citations

Ionotropic Glutamate Receptor Modulation of 5-HT6 and 5-HT7 mRNA Expression in Rat Brain

1999 • 40 citations

Identification of a human 5-HT6 receptor variant produced by alternative splicing

1999 • 38 citations

Characterization of 5-ht6 receptor and expression of 5-ht6 mRNA in the rat brain during ontogenetic development

1998 • 36 citations

Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells

2000 • 34 citations

Creation, expression, and characterization of a constitutively active mutant of the human serotonin 5‐HT₆ receptor

2002 • 34 citations

Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245

2004 • 34 citations

Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease

2001 • 30 citations

Effects of 5-HT 6 receptor blockade on the neurochemical outcome of antidepressant treatment in the frontal cortex of the rat

2003 • 28 citations

Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus

2004 • 24 citations

Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese

2004 • 24 citations

Association study of the 5-hydroxytryptamine6 receptor gene in Alzheimer's disease

2002 • 22 citations

Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson’s disease

2002 • 22 citations

Novel polymorphism in the 5′-upstream region of the human 5-HT6 receptor gene and schizophrenia

2001 • 21 citations

5-Hydroxytryptamine 6 receptor (5-HT6) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country

2003 • 20 citations

Central Distribution and Function of 5‐ht₆ Receptor Subtype in the Rat Brain

1998 • 18 citations

Regulation of glial Na+/K+-ATPase by serotonin: identification of participating receptors.

1999 • 17 citations

List of Drugs in Development for Neurodegenerative Diseases

2004 • 12 citations

Family‐based association study of the serotonin‐6 receptor gene (C267T polymorphism) in schizophrenia

2003 • 8 citations