Treatment With Lorcaserin for Cocaine Use: The TLC Study

NCT03192995

PHASE2INTERVENTIONAL

Glenn-Milo Santos

22 participants

Started 2018-01-01 · Completed 2020-06-30

Status: Terminated (as of 12-23-2025)

Conditions

Cocaine Use Disorder

Interventions

DRUG: lorcaserin DRUG: Placebo Oral Tablet BEHAVIORAL: Substance use counseling BEHAVIORAL: ACASI DIAGNOSTIC_TEST: Cocaine metabolites+3 more

Linked Papers (from SciSciNet-V2)

Total Papers27

Background

27

Result

0

Derived

0

Unknown

0

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This project is a placebo-controlled, double-blind randomized trial evaluating the feasibility, tolerability, acceptability and adherence for lorcaserin among actively using, men who have sex with men (MSM) with cocaine use disorders.The study will enroll 45 individuals who will randomly be assigned to either the treatment (lorcaserin) arm or the placebo arm, to be taken twice a day for 12 weeks.

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Background Papers27

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

Statistics Notes: Blinding in clinical trials and other studies

Drug Use and Medication Adherence among HIV-1 Infected Individuals

Specific Sex Drug Combinations Contribute to the Majority of Recent HIV Seroconversions Among MSM in the MACS

Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women

Real-Time Adherence Monitoring for HIV Antiretroviral Therapy

The Barratt Impulsiveness Scale–11: Reassessment of its structure in a community sample.

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control

Mirtazapine to Reduce Methamphetamine Use

Pharmacotherapy for Cocaine Use Disorder—a Systematic Review and Meta-analysis

Reduced Forebrain Serotonin Transmission is Causally Involved in the Development of Compulsive Cocaine Seeking in Rats

Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

Walking the line: Stimulant use during sex and HIV risk behavior among Black urban MSM

Dose-Response Associations Between Number and Frequency of Substance Use and High-Risk Sexual Behaviors Among HIV-Negative Substance-Using Men Who Have Sex With Men (SUMSM) in San Francisco

Effects of Serotonin 2C Receptor Agonists on the Behavioral and Neurochemical Effects of Cocaine in Squirrel Monkeys

Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens

Factors associated with event-level stimulant use during sex in a sample of older, low-income men who have sex with men in Los Angeles

Cumulative exposure to stimulants and immune function outcomes among HIV-positive and HIV-negative men in the Multicenter AIDS Cohort Study

Symptoms of substance dependence and risky sexual behavior in a probability sample of HIV-negative men who have sex with men in Chicago

A Novel, Nonbinary Evaluation of Success and Failure Reveals Bupropion Efficacy Versus Methamphetamine Dependence: Reanalysis of a Multisite Trial

The serotonin-2C agonist Lorcaserin delays intravenous choice and modifies the subjective and cardiovascular effects of cocaine: A randomized, controlled human laboratory study

Predictors of HIV Sexual Risk Behavior Among Men Who Have Sex with Men, Men Who Have Sex with Men and Women, and Transgender Women

Estimating the contribution of stimulant injection to HIV and HCV epidemics among people who inject drugs and implications for harm reduction: A modeling analysis

Feasibility and acceptability of a phase II randomized pharmacologic intervention for methamphetamine dependence in high-risk men who have sex with men

Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization

5‐HT_2A receptor blockade and 5‐HT_2C receptor activation interact to reduce cocaine hyperlocomotion and fos protein expression in the caudate‐putamen

Learning from lorcaserin: lessons from the negative clinical trial of lorcaserin to treat cocaine use disorder

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers0

No unknown papers linked