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Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration

Data up to Jan 2025

Published2003
Citations130
References60

Total Citations Per Year

Abstract

References (60)

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

A review of central 5-HT receptors and their function

1999 • 3,121 citations

A stereotaxic atlas of the rat brain

1980 • 2,782 citations

Molecular, pharmacological and functional diversity of 5-HT receptors

2002 • 1,822 citations

Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

1996 • 1,301 citations

Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

1994 • 861 citations

Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine

2002 • 783 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

1997 • 519 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

1983 • 491 citations

Neuropsychopharmacology

2003 • 430 citations

A Critique of Fixed and Progressive Ratio Schedules Used to Examine the Neural Substrates of Drug Reinforcement

1997 • 387 citations

Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat

2000 • 333 citations

5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential.

1998 • 324 citations

Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement.

1996 • 301 citations

Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat

1995 • 293 citations

Fluoxetine reduces intravenous cocaine self-administration in rats

1990 • 254 citations

Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding

2002 • 247 citations

SB 242 084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system

1999 • 244 citations

Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats

1997 • 240 citations

Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera

1995 • 240 citations

Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin

1990 • 231 citations

Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens

1991 • 226 citations

Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement

1996 • 225 citations

Parameters of self-administration of cocaine in rats under a progressive-ratio schedule

1993 • 217 citations

Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement

1993 • 214 citations

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

2000 • 209 citations

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats

1996 • 196 citations

Effects of medial prefrontal or anterior cingulate cortex lesions on responding for cocaine under fixed-ratio and second-order schedules of reinforcement in rats

1997 • 188 citations

Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat

1991 • 182 citations

Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin2C receptors

2000 • 179 citations

Serotonin and drug reward: focus on 5-HT2C receptors

2003 • 155 citations

Response of nicotine self-administration in the rat to manipulations of mu-opioid and γ-aminobutyric acid receptors in the ventral tegmental area

2000 • 154 citations

Enhanced Locomotor, Reinforcing, and Neurochemical Effects of Cocaine in Serotonin 5-Hydroxytryptamine 2C Receptor Mutant Mice

2002 • 152 citations

Role of serotonin2C receptors in the control of brain dopaminergic function

2002 • 151 citations

Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules

2000 • 149 citations

3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions.

2001 • 145 citations

Supersensitivity to the reinforcing effects of cocaine following 6-hydroxydopamine lesions to the medial prefrontal cortex in rats

1991 • 144 citations

Differential Actions of Serotonin, Mediated by 5-HT1Band 5-HT2CReceptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata NeuronsIn Vitro

1996 • 143 citations

The GABAB agonist baclofen modifies cocaine self-administration in rats.

1998 • 139 citations

Excitatory responses to serotonin (5‐HT) in neurons of the rat piriform cortex: Evidence for mediation by 5‐HT1C receptors in pyramidal cells and 5‐HT2 receptors in interneurons

1991 • 132 citations

Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat

1993 • 130 citations

m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors

2001 • 124 citations

Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine

2001 • 120 citations

Serotonin 5-HT2C receptors in nucleus accumbens regulate expression of the hyperlocomotive and discriminative stimulus effects of cocaine

2002 • 109 citations

An investigation of the role of 5-HT2C receptors in modifying ethanol self-administration behaviour

2002 • 93 citations

Intra-VTA Baclofen Attenuates Cocaine Self-Administration on a Progressive Ratio Schedule of Reinforcement

2000 • 90 citations

Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-administration under both a fixed and progressive ratio schedule of reinforcement

1995 • 86 citations

L-Tryptophan decreases the breaking point under a progressive ratio schedule of intravenous cocaine reinforcement in the rat

1993 • 84 citations

Characterization of phospholipase C activity at h5-HT 2C compared with h5-HT 2B receptors: influence of novel ligands upon membrane-bound levels of [ 3 H]phosphatidylinositols

2002 • 82 citations

Effects of the 5-HT2C/2B Antagonist SB 206553 on Hyperactivity Induced by Cocaine

1999 • 81 citations

Comparison of changes in extracellular dopamine concentrations in the nucleus accumbens during intravenous self-administration of cocaine or d-amphetamine

1995 • 73 citations

Dietary tryptophan supplements attenuate amphetamine self-administration in the rat

1986 • 70 citations

The effects of ventral tegmental administration of GABAA, GABAB and NMDA receptor agonists on medial forebrain bundle self-stimulation

1995 • 69 citations

Functional Interaction between Serotonin and Other Neuronal Systems: Focus on In Vivo Microdialysis Studies

1996 • 60 citations

Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO60-0175: a pharmacological analysis

1999 • 60 citations

Effects of Ventral Tegmental Microinjections of the GABAA Agonist Muscimol on Self-Administration of Ethanol and Sucrose

1996 • 52 citations

Neuropeptide Y-induced operant responding for sucrose is not mediated by dopamine

1998 • 36 citations

Effect of typical and atypical neuroleptics on the behavioural consequences of activation by muscimol of mesolimbic and nigro-striatal dopaminergic pathways in the rat

1991 • 28 citations

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Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area… (2003) – Neuropsychopharmacology | Metascience Observatory Explorer