SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

1994 • 861 citations

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

1988 • 822 citations

CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?

1978 • 782 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

1993 • 588 citations

Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes

1987 • 406 citations

Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor

1992 • 402 citations

Inverse agonist activity of beta-adrenergic antagonists.

1994 • 357 citations

The pharmacology and distribution of human 5‐hydroxytryptamine_2B (5‐HT_2b) receptor gene products: comparison with 5‐HT_2a and 5‐HT_2c receptors

1995 • 299 citations

m-Chlorophenylpiperazine as a probe of serotonin function

1991 • 291 citations

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

1993 • 281 citations

Evidence that hypophagia induced bymCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors

1988 • 257 citations

The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination

1962 • 240 citations

In vitro and in vivo profile of SB 206553, a potent 5‐HT_2C/5‐HT_2B receptor antagonist with anxiolytic‐like properties

1996 • 239 citations

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

1991 • 225 citations

Characterization and distribution of putative 5‐ht₇ receptors in guinea‐pig brain

1995 • 223 citations

m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats

1979 • 221 citations

Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system

1997 • 206 citations

Cloning and functional characterization of the rat stomach fundus serotonin receptor.

1992 • 192 citations

In vivo properties of SB 200646A, a 5‐HT_2C/2B receptor antagonist

1994 • 182 citations

Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus.

1992 • 181 citations

Nonlinear regression using spreadsheets

1995 • 160 citations

Cloning and functional characterization of the human 5‐HT_2B serotonin receptor

1994 • 150 citations

Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

1993 • 144 citations

New mouse 5‐HT2‐like receptor Expression in brain, heart and intestine

1992 • 123 citations

5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats

1996 • 120 citations

Characterization of α1-adrenoceptor subtypes in prostate and prostatic urethra of rat, rabbit, dog and man

1993 • 115 citations

Effects of the 5‐HT_2B receptor agonist, BW 723C86, on three rat models of anxiety

1996 • 108 citations

Increased food intake in satiated rats induced by the 5-HT antagonists methysergide, metergoline and ritanserin

1988 • 106 citations

Activation of 5-HT 2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat

1997 • 99 citations

Evidence that blockade of post-synaptic 5-HT1 receptors elicits feeding in satiated rats

1989 • 92 citations

d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors

1993 • 82 citations

Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety

1995 • 72 citations

5‐HT_2B receptor‐mediated calcium release from ryanodine‐sensitive intracellular stores in human pulmonary artery endothelial cells

1996 • 71 citations

(+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity

1995 • 58 citations

Characterisation of Human 5‐Hydroxytryptamine_2A and 5‐Hydroxytryptamine_2C Receptors Expressed in the Human Neuroblastoma Cell Line SH‐SY5Y: Comparative Stimulation by Hallucinogenic Drugs

1996 • 45 citations

Regulation of phenylethanolamine N-methyltransferase synthesis and degradation. II. Control of the thermal stability of the enzyme by an endogenous stabilizing factor.

1978 • 16 citations

S-17-5 5HT2C receptor agonists and antagonists in animal models of anxiety

1995 • 16 citations