Integrated signalling pathways for mast-cell activation

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Depletion of intracellular calcium stores activates a calcium current in mast cells

1992 • 1,748 citations

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

2005 • 1,680 citations

Mast cells

1997 • 1,636 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Mast cells in the development of adaptive immune responses

2005 • 1,252 citations

LAT

1998 • 1,251 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Mast-cell responses to pathogens

2004 • 833 citations

Middleton’s Allergy: Principles and Practice

2013 • 823 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Middleton's Allergy: Principles and Practice

2013 • 609 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Heterogeneity of Mast Cells and Phenotypic Change Between Subpopulations

1989 • 484 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

A Role for Lipid Rafts in B Cell Antigen Receptor Signaling and Antigen Targeting

1999 • 473 citations

The role of PI3K in immune cells

2003 • 460 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene

1993 • 395 citations

Early signaling pathways activated by c-Kit in hematopoietic cells

1999 • 385 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

2004 • 384 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Signal transduction by Fc receptors: the Fc&RI case

1993 • 373 citations

Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses.

1991 • 369 citations

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

1993 • 369 citations

Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.

1977 • 366 citations

T cell costimulation by chemokine receptors

2005 • 336 citations

LAT Is Essential for FcεRI-Mediated Mast Cell Activation

2000 • 332 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.

1992 • 308 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

2002 • 293 citations

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.

1996 • 292 citations

The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.

1993 • 279 citations

c-kit ligand: a unique potentiator of mediator release by human lung mast cells.

1992 • 275 citations

Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement

1991 • 272 citations

The Receptor with High Affinity for IgE

1992 • 266 citations

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

1997 • 251 citations

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production

1998 • 249 citations

IL-4 enhances proliferation and mediator release in mature human mast cells

1999 • 248 citations

Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.

1993 • 232 citations

Complete structure of the mouse mast cell receptor for IgE (Fc ϵ RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

1989 • 231 citations

BTK Regulates PtdIns-4,5-P2 Synthesis

2003 • 214 citations

Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses

1998 • 210 citations

Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase

2004 • 209 citations

Non–T Cell Activation Linker (NTAL)

2002 • 203 citations

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.

1994 • 194 citations

Inhibition of IgE‐induced activation of human mast cells by IL‐10

2001 • 177 citations

Akt-Dependent Cytokine Production in Mast Cells

2000 • 176 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

Structure-Function Analysis of Lyn Kinase Association with Lipid Rafts and Initiation of Early Signaling Events after Fcɛ Receptor I Aggregation

2001 • 175 citations

A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation

2003 • 167 citations

Molecular adapters in FcεRI signaling and the allergic response

2002 • 166 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

2002 • 164 citations

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation

2000 • 164 citations

Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.

1997 • 163 citations

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

2001 • 156 citations

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

2000 • 155 citations

Kit and FcϵRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells

2004 • 154 citations

LAB: A new membrane-associated adaptor molecule in B cell activation

2003 • 154 citations

Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3 or IL-4.

1993 • 154 citations

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

1999 • 154 citations

Regulation of phospholipase C γ isoforms in haematopoietic cells

2001 • 145 citations

Protein-tyrosine phosphorylation: an essential component of FcεRI signaling

1992 • 141 citations

Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.

1995 • 137 citations

A High-Affinity Arg-X-X-Lys SH3 Binding Motif Confers Specificity for the Interaction between Gads and SLP-76 in T Cell Signaling

2002 • 134 citations

Dependence of mast cell IgE-mediated cytokine production on nuclear factor-κB activity

2000 • 132 citations

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

1998 • 131 citations

Sphingolipids and the Balancing of Immune Cell Function: Lessons from the Mast Cell

2005 • 130 citations

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc RI aggregation

2004 • 128 citations

Negative Regulation of Mast Cell Signaling and Function by the Adaptor LAB/NTAL

2004 • 126 citations

Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase

2004 • 125 citations

Syk-dependent Phosphorylation of Shc

1996 • 124 citations

Dysregulated FcεRI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells

2004 • 122 citations

IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production

2000 • 118 citations

Positive and Negative Regulation of FcεRI-Mediated Signaling by the Adaptor Protein LAB/NTAL

2004 • 117 citations

Activation of human mast cells by aggregated IgG through FcγRI: additive effects of C3a

2003 • 117 citations

Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells.

1999 • 114 citations

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

1997 • 113 citations

The Phospholipase Cγ1-dependent Pathway of FcϵRI-mediated Mast Cell Activation Is Regulated Independently of Phosphatidylinositol 3-Kinase

2003 • 109 citations

Macrophage inflammatory protein–1α as a costimulatory signal for mast cell–mediated immediate hypersensitivity reactions

2005 • 108 citations

TGF-β1 Inhibits Mast Cell FcεRI Expression

2005 • 106 citations

The FcϵRIβ Immunoreceptor Tyrosine-based Activation Motif Exerts Inhibitory Control on MAPK and IκB Kinase Phosphorylation and Mast Cell Cytokine Production

2004 • 105 citations

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3.

1997 • 105 citations

Structural Aspects of the Association of FcεRI with Detergent-resistant Membranes

1999 • 105 citations

A Comparison of Mediators Released or Generated by IFN-γ-Treated Human Mast Cells Following Aggregation of FcγRI or FcεRI

2001 • 103 citations

Wortmannin-Sensitive Phosphorylation, Translocation, and Activation of PLCγ1, but Not PLCγ2, in Antigen-stimulated RBL-2H3 Mast Cells

1998 • 100 citations

Knock-in Mutation of the Distal Four Tyrosines of Linker for Activation of T Cells Blocks Murine T Cell Development

2001 • 98 citations

Mitogen-Activated Protein Kinase Activation Through Fcε Receptor I and Stem Cell Factor Receptor Is Differentially Regulated by Phosphatidylinositol 3-Kinase and Calcineurin in Mouse Bone Marrow-Derived Mast Cells

1999 • 96 citations

Activation of phospholipase D in a rat mast (RBL 2H3) cell line. A possible unifying mechanism for IgE-dependent degranulation and arachidonic acid metabolite release.

1991 • 91 citations

Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products

2000 • 87 citations

The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation

2003 • 85 citations

Nuclear Factor of Activated T Cells c Is a Target of p38 Mitogen-Activated Protein Kinase in T Cells

2003 • 84 citations

Grb2 and the Non-T Cell Activation Linker NTAL Constitute a Ca2+-Regulating Signal Circuit in B Lymphocytes

2004 • 84 citations

IL-4 inhibits mouse mast cell Fc epsilonRI expression through a STAT6-dependent mechanism.

1998 • 81 citations

Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun.

1994 • 79 citations

Differential regulation of mast cell function by IL-10 and stem cell factor.

1997 • 76 citations

Induction of tumor necrosis factor-alpha production by mast cells via Fc gamma R. Role of the Fc gamma RIII gamma subunit.

1992 • 71 citations

The mastocyte: the “other” inflammatory cell in immunopathogenesis

2004 • 71 citations

Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

2004 • 69 citations

Stem-cell factor, the kit ligand, induces direct degranulation of rat peritoneal mast cells in vitro and in vivo: dependence of the in vitro effect on period of culture and comparisons of stem-cell factor with other mast cell-activating agents.

1995 • 68 citations

IL-10 Inhibits FcεRI Expression in Mouse Mast Cells

2004 • 67 citations

IL-4 Inhibits Mouse Mast Cell FcεRI Expression Through a STAT6-Dependent Mechanism

1998 • 67 citations

Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release

2002 • 66 citations

Antigen and carbachol mobilize calcium by similar mechanisms in a transfected mast cell line (RBL-2H3 cells) that expresses ml muscarinic receptors.

1993 • 65 citations

TGF-beta1 inhibits the release of histamine and tumor necrosis factor-alpha from mast cells through an autocrine pathway.

1997 • 63 citations

Interaction of Phosphorylated FcϵRIγ Immunoglobulin Receptor Tyrosine Activation Motif-based Peptides with Dual and Single SH2 Domains of p72

1996 • 62 citations

Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells

1998 • 60 citations

Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells

1997 • 59 citations

CC Chemokine Receptor 3 Mobilizes to the Surface of Human Mast Cells and Potentiates Immunoglobulin E–Dependent Generation of Interleukin 13

2003 • 56 citations

Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells.

1998 • 56 citations

Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation

2003 • 55 citations

Fc epsilonRI-mediated induction of TNF-alpha gene expression in the RBL-2H3 mast cell line: regulation by a novel NF-kappaB-like nuclear binding complex.

1998 • 53 citations

NTAL/LAB and LAT: a balancing act in mast-cell activation and function

2005 • 52 citations

The case for a role for adenosine in asthma: almost convincing?

2003 • 52 citations

Cutting Edge: Localization of Linker for Activation of T Cells to Lipid Rafts Is Not Essential in T Cell Activation and Development

2005 • 52 citations

Differential regulation of NFAT and SRF by the B cell receptor via a PLC -Ca2+-dependent pathway

2003 • 48 citations

Stem Cell Factor Augments FcεRI-Mediated TNF-α Production and Stimulates MAP Kinases via a Different Pathway in MC/9 Mast Cells

1998 • 46 citations

ZAP-70 Is Essential for the T Cell Antigen Receptor-induced Plasma Membrane Targeting of SOS and Vav in T Cells

2000 • 44 citations

FcεRI-Mediated Induction of TNF-α Gene Expression in the RBL-2H3 Mast Cell Line: Regulation by a Novel NF-κB-Like Nuclear Binding Complex

1998 • 43 citations

Defective degranulation and calcium mobilization of bone-marrow derived mast cells from Xid and Btk-deficient mice

1998 • 43 citations

Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.

1998 • 37 citations

Functional contributions of the FcepsilonRIalpha and FepsilonRIgamma subunit domains in FcepsilonRI-mediated signaling in mast cells.

1996 • 26 citations

Roles of Adaptor Molecules in Mast Cell Activation

2005 • 25 citations

Expression and Function of FcγR in Mouse Mast Cells

1995 • 25 citations

IL-4 selectively enhances FcγRIII expression and signaling on mouse mast cells

2003 • 21 citations

The Role of Sphingosine Kinase in the Signaling Initiated at the High-Affinity Receptor for IgE (FcεRI) in Mast Cells

2000 • 15 citations