Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

2003 • 427 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains

1997 • 353 citations

LAT Is Essential for FcεRI-Mediated Mast Cell Activation

2000 • 332 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

1995 • 290 citations

Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

1997 • 278 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Purification and Characterization of Rat Kidney Sphingosine Kinase

1998 • 221 citations

Negative Regulation of Immunoglobulin E–dependent Allergic Responses by Lyn Kinase

2004 • 209 citations

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

1998 • 208 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.

1994 • 194 citations

Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase.

1994 • 180 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

1999 • 175 citations

FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking

1998 • 172 citations

A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation

2003 • 167 citations

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation

2000 • 164 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

2002 • 164 citations

Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.

1997 • 163 citations

The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion

1998 • 129 citations

Sphingosine Is a Novel Activator of 3-Phosphoinositide-dependent Kinase 1

2000 • 102 citations

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.

1988 • 93 citations

Identification and Characterization of RPK118, a Novel Sphingosine Kinase-1-binding Protein

2002 • 92 citations

Regulatory Effect of Phorbol Esters on Sphingosine Kinase in BALB/C 3T3 Fibroblasts (Variant A31): Demonstration of Cell Type-Specific Response - A Preliminary Note

1994 • 87 citations

The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation

2003 • 85 citations

Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity

2002 • 85 citations

Activation of casein kinase II by sphingosine.

1991 • 70 citations

The Signal Modulator Protein-14-3-3 Ts a Target of Sphingosine-Dependent or N,N-Dimethylsphingosine-Dependent Kinase in 3T3(A31) Cells

1995 • 65 citations

Sphingolipids and the regulation of the immune response

2002 • 61 citations

Sphingolipids: second messengers, mediators and raft constituents in signaling

2000 • 60 citations

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1997 • 59 citations

p21ras links Fc epsilon RI to NF-AT family member in mast cells. The AP3-like factor in this cell type is an NF-AT family member.

1995 • 38 citations

Export of the High Affinity IgE Receptor From the Endoplasmic Reticulum Depends on a Glycosylation-Mediated Quality Control Mechanism

2000 • 35 citations

Lyn dissociation from phosphorylated Fc epsilon RI subunits: a new regulatory step in the Fc epsilon RI signaling cascade revealed by studies of Fc epsilon RI dimer signaling activity.

1999 • 31 citations

Mast cells stimulated by membrane-bound, but not soluble, steel factor are dependent on phospholipase C activation

2003 • 27 citations

Lyn Dissociation from Phosphorylated FcεRI Subunits: A New Regulatory Step in the FcεRI Signaling Cascade Revealed by Studies of FcεRI Dimer Signaling Activity

1999 • 23 citations

Gene Regulation after Fc Epsilon Rl Stimulation in the Murine Mast Cell Line CPII

1997 • 14 citations

Glycosphingolipid-Induced Relocation of Lyn and Syk into Detergent-Resistant Membranes Results in Mast Cell Activation

2000 • 12 citations

Effects of protein kinase C and phospholipase C inhibitors on IgE-dependent and IgE-independent basophil histamine release

2000 • 4 citations