Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q

1989 • 624 citations

High-affinity IgE receptor on eosinophils is involved in defence against parasites

1994 • 524 citations

Complete structure and expression in transfected cells of high affinity IgE receptor

1989 • 515 citations

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).

1992 • 490 citations

A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells

1996 • 479 citations

Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice

1996 • 452 citations

Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

1994 • 406 citations

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene

1993 • 395 citations

Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI.

1992 • 388 citations

Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.

1994 • 378 citations

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor.

1994 • 367 citations

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

1997 • 363 citations

The FcεRIβ Subunit Functions as an Amplifier of FcεRIγ-Mediated Cell Activation Signals

1996 • 346 citations

Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation.

1996 • 332 citations

Localisation of atopy and β subunit of high-affinity IgE receptor (Fc&amp;isin;RI) on chromosome 11q

1993 • 294 citations

Neutrophil Recruitment by Tumor Necrosis Factor from Mast Cells in Immune Complex Peritonitis

1992 • 285 citations

DOES T4 TOXICOSIS EXIST ?

1975 • 252 citations

Complete structure of the mouse mast cell receptor for IgE (Fc ϵ RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells

1989 • 231 citations

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

1989 • 216 citations

Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.

1997 • 195 citations

Expression of High-affinity Binding of Human Immunoglobulin E by Transfected Cells

1989 • 194 citations

The Cells of the Allergic Response

1997 • 182 citations

A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness

1996 • 177 citations

The Emerging Field of Receptor-Mediated Inhibitory Signaling: SHP or SHIP?

1996 • 174 citations

Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering.

1995 • 159 citations

Fc(epsilon)RI-(beta) polymorphism and risk of atopy in a general population sample

1995 • 151 citations

The Negative Signaling Molecule SH2 Domain-containing Inositol-Polyphosphate 5-Phosphatase (SHIP) Binds to the Tyrosine-phosphorylated β Subunit of the High Affinity IgE Receptor

1997 • 143 citations

A Requirement for Syk in the Activation of the Microtubule-associated Protein Kinase/Phospholipase A2 Pathway by FcεR1 Is Not Shared by a G Protein-coupled Receptor

1995 • 142 citations

Linkage between severe atopy and chromosome 11q13 in Japanese families

1994 • 119 citations

Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII).

1991 • 114 citations

Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E.

1988 • 109 citations

Anaphylaxis mediated through a humanized high affinity IgE receptor.

1996 • 108 citations

Anaphylaxis mediated through a humanized high affinity IgE receptor.

1996 • 97 citations

Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin E

1988 • 96 citations

The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.

1992 • 94 citations

Downstream Signaling Molecules Bind to Different Phosphorylated Immunoreceptor Tyrosine-based Activation Motif (ITAM) Peptides of the High Affinity IgE Receptor

1996 • 85 citations

Maturational steps of bone marrow-derived dendritic murine epidermal cells. Phenotypic and functional studies on Langerhans cells and Thy-1+ dendritic epidermal cells in the perinatal period.

1989 • 83 citations

The beta subunit of the Fc epsilon RI is associated with the Fc gamma RIII on mast cells.

1992 • 79 citations

Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor.

1997 • 77 citations

Functional comparison of Fc epsilon RI, Fc gamma RII, and Fc gamma RIII in mast cells.

1992 • 56 citations

Fcϵ receptor‐positive cells are a major source of antigen‐induced interIeukin‐4 in spleens of mice infected with Schistosoma mansoni

1993 • 44 citations

Mapping of murine IgE epitopes involved in IgE‐Fc_ε receptor interactions

1989 • 35 citations