SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

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Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

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T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

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Interleukin 4 is localized to and released by human mast cells.

1992 • 589 citations

Complete structure and expression in transfected cells of high affinity IgE receptor

1989 • 515 citations

BLNK

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Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function

1996 • 460 citations

IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions

1997 • 448 citations

Active anaphylaxis in IgE-deficient mice

1994 • 414 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene

1993 • 395 citations

Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses.

1991 • 369 citations

Recent advances in the cellular and molecular biology of mast cells

1989 • 366 citations

Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

1997 • 363 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

The FcεRIβ Subunit Functions as an Amplifier of FcεRIγ-Mediated Cell Activation Signals

1996 • 346 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells.

1996 • 292 citations

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

1998 • 271 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

Fc receptor-mediated phagocytosis requires CDC42 and Rac1

1998 • 254 citations

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production

1998 • 249 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ/CD3 Induction of Interleukin-2

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Membrane and cytoskeletal changes associated with IgE-mediated serotonin release from rat basophilic leukemia cells.

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p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

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Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice

1997 • 169 citations

Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.

1997 • 163 citations

Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: Enhanced IL-13 production by IL-4–primed human mast cells

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Surface expression of functional IgE binding protein, an endogenous lectin, on mast cells and macrophages.

1992 • 156 citations

Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII.

1992 • 140 citations

SLP-76 Is a Direct Substrate of SHP-1 Recruited to Killer Cell Inhibitory Receptors

1998 • 136 citations

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

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Paired Immunoglobulin-like Receptor (PIR)-A Is Involved in Activating Mast Cells through Its Association with Fc Receptor γ Chain

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Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

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The role of Grb2-associated proteins in T-cell activation

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SLP-76 Is a Substrate of the High Affinity IgE Receptor-stimulated Protein Tyrosine Kinases in Rat Basophilic Leukemia Cells

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Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses.

1993 • 59 citations

Association of a p95 Vav-containing Signaling Complex with the FcϵRI γ Chain in the RBL-2H3 Mast Cell Line

1996 • 56 citations

Early and late events in Fc epsilon RI signal transduction in human cultured mast cells.

1997 • 56 citations

Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses.

1991 • 53 citations

Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking

1996 • 50 citations

Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice.

1993 • 48 citations

TcRζ/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB

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1996 • 11 citations