The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1990 • 889 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Lysosphingolipids Inhibit Protein Kinase C: Implications for the Sphingolipidoses

1987 • 593 citations

Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines.

1989 • 557 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules.

1995 • 172 citations

The Inducible G Protein-coupled Receptor edg-1 Signals via the Gi/Mitogen-activated Protein Kinase Pathway

1996 • 167 citations

Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.

1994 • 147 citations

A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation.

1995 • 99 citations

Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF promoter in stimulated mast cells

1998 • 86 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Ceramide induces interleukin 6 gene expression in human fibroblasts.

1995 • 81 citations

Sphingosine-1-phosphate Mobilizes Intracellular Calcium and Activates Transcription Factor NF-κB in U937 Cells

1997 • 71 citations

Protein Kinase C Regulates Fas (CD95/APO-1) Expression

1998 • 71 citations

Different Protein Kinase C Isoenzymes Regulate IL-2 Receptor Expression or IL-2 Synthesis in Human Lymphocytes Stimulated via the TCR

1998 • 68 citations

A novel splice variant of the transcription factor Nrf1 interacts with the TNF promoter and stimulates transcription

1998 • 48 citations

Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.

1996 • 43 citations

Common and distinct signaling pathways mediate the induction of TNF-alpha and IL-5 in IgE plus antigen-stimulated mast cells.

1998 • 42 citations

The Phosphorylation State of CD3γ Influences T Cell Responsiveness and Controls T Cell Receptor Cycling

1998 • 40 citations

Demonstration of differential effects of cytokines on mast cells derived from murine bone marrow and peripheral blood mononuclear cells.

1994 • 36 citations

Sphingolipids

1996 • 35 citations

Induction of the TNF-alpha promoter in the murine dendritic cell line 18 and the murine mast cell line CPII is differently regulated.

1996 • 34 citations

Common and Distinct Signaling Pathways Mediate the Induction of TNF-α and IL-5 in IgE Plus Antigen-Stimulated Mast Cells

1998 • 32 citations

Effects of Phosphatidylinositol-3-Kinase Inhibitors on Degranulation and Gene Induction in Allergically Triggered Mouse Mast Cells

1997 • 30 citations

Involvement of Mac-1-Mediated Adherence and Sphingosine 1-Phosphate in Survival of Phorbol Ester-Treated U937 Cells

1998 • 28 citations

Activation of a retinoblastoma-protein-dependent pathway by sphingosine

1995 • 22 citations

Th2 Suppressor Cells Are More Susceptible to Sphingosine Than Th1 Cells in Murine Contact Photosensitivity

1996 • 15 citations