Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1976 • 237 citations

Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

1976 • 171 citations

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

1979 • 118 citations

Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in Leukæmia

1961 • 107 citations

Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin.

1972 • 101 citations

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1977 • 95 citations

Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate.

1979 • 93 citations

SITES OF ACTION OF AMETHOPTERIN: INTRINSIC AND ACQUIRED DRUG RESISTANCE*

1971 • 87 citations

Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells

1975 • 80 citations

Isolation and Characterization of the Multiple Forms of Dihydrofolate Reductase from Methotrexate-resistant Hamster Cells

1974 • 49 citations

Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux

1976 • 42 citations

Genetic characterization of methotrexate-resistant chinese hamster ovary cells

1976 • 41 citations

Enzymic and transport mechanisms of amethopterin resistance in l1210 mouse leukemia cells.

1975 • 25 citations

Sequential Biochemical Alteration to Antifolate Resistance in L121O Leukaemia

1967 • 17 citations