SOCS3 negatively regulates IL-6 signaling in vivo

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

1996 • 1,498 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Acre-transgenic mouse strain for the ubiquitous deletion ofloxP-flanked gene segments including deletion in germ cells

1995 • 1,269 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

Suppressors of cytokine signalling (SOCS) in the immune system

2002 • 633 citations

Defective inflammatory response in interleukin 6-deficient mice.

1994 • 540 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo

1994 • 460 citations

SOCS3 regulates the plasticity of gp130 signaling

2003 • 433 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

1995 • 420 citations

The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities

1998 • 404 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

2001 • 331 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

2001 • 302 citations

Mutational switch of an IL-6 response to an interferon-γ-like response

2002 • 262 citations

Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS

2002 • 262 citations

Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

1999 • 245 citations

STAT3 Is a Negative Regulator of Granulopoiesis but Is Not Required for G-CSF-Dependent Differentiation

2002 • 244 citations

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 239 citations

Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system

1994 • 234 citations

Interleukin 6 is essential for in vivo development of B lineage neoplasms.

1995 • 233 citations

Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS

2002 • 230 citations

Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival

1998 • 225 citations

Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10–Induced Pathway That Is Independent of STAT Protein Activation

1999 • 212 citations

Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation

1991 • 212 citations

SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

2003 • 201 citations

Lipopolysaccharide Induces in Macrophages the Synthesis of the Suppressor of Cytokine Signaling 3 and Suppresses Signal Transduction in Response to the Activating Factor IFN-γ

1999 • 191 citations

Interferon γ Induces the Expression of p21waf-1 and Arrests Macrophage Cell Cycle, Preventing Induction of Apoptosis

1999 • 183 citations

Expression of suppressors of cytokine signaling during liver regeneration

2001 • 152 citations

Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transduction in Vitro and in Vivo

2001 • 106 citations