A superfamily of protein tags: ubiquitin, SUMO and related modifiers

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

2002 • 2,139 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes

2003 • 1,999 citations

Structure of ubiquitin refined at 1.8 Å resolution

1987 • 1,682 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

2002 • 1,442 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

2002 • 1,050 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 • 768 citations

Sumo, ubiquitin's mysterious cousin

2001 • 749 citations

Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

2001 • 687 citations

Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1

2002 • 680 citations

Structural Basis for E2-Mediated SUMO Conjugation Revealed by a Complex between Ubiquitin-Conjugating Enzyme Ubc9 and RanGAP1

2002 • 562 citations

The Small Ubiquitin-like Modifier-1 (SUMO-1) Consensus Sequence Mediates Ubc9 Binding and Is Essential for SUMO-1 Modification

2001 • 506 citations

Trans-histone regulatory pathway in chromatin

2002 • 502 citations

UBP43 (USP18) Specifically Removes ISG15 from Conjugated Proteins

2002 • 488 citations

Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein

2001 • 487 citations

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF ^TIR1 in Mediating Auxin Response

2001 • 463 citations

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation

2001 • 463 citations

Ubiquitin in chains

2000 • 445 citations

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.

1987 • 430 citations

Evolution and function of ubiquitin-like protein-conjugation systems

2000 • 394 citations

Ubiquitin Enters the New Millennium

2001 • 390 citations

Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

2002 • 366 citations

SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization

2002 • 365 citations

NEDD8 recruits E2-ubiquitin to SCF E3 ligase

2001 • 321 citations

Ubiquitin and its kin: how close are the family ties?

2000 • 316 citations

Protein ISGylation modulates the JAK-STAT signaling pathway

2003 • 313 citations

NEDD8 Modification of CUL1 Dissociates p120CAND1, an Inhibitor of CUL1-SKP1 Binding and SCF Ligases

2002 • 309 citations

CAND1 Binds to Unneddylated CUL1 and Regulates the Formation of SCF Ubiquitin E3 Ligase Complex

2002 • 302 citations

Structural insights into the U-box, a domain associated with multi-ubiquitination

2003 • 276 citations

Transcription factor Sp3 is silenced through SUMO modification by PIAS1

2002 • 261 citations

The SUMO-1 Isopeptidase Smt4 Is Linked to Centromeric Cohesion through SUMO-1 Modification of DNA Topoisomerase II

2002 • 251 citations

High-throughput Immunoblotting

2003 • 245 citations

Ubiquitin-Activating/Conjugating Activity of TAF _II 250, a Mediator of Activation of Gene Expression in Drosophila

2000 • 238 citations

Making sense of the COP9 signalosome: a regulatory protein complex conserved from Arabidopsis to human

1999 • 237 citations

Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2EPF and RAD6 Are Recognized by 26 S Proteasome Subunit 5

1996 • 221 citations

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

2002 • 220 citations

Recognition of Specific Ubiquitin Conjugates Is Important for the Proteolytic Functions of the Ubiquitin-associated Domain Proteins Dsk2 and Rad23

2002 • 209 citations

Crystal Structure of the Human Ubiquitin-like Protein NEDD8 and Interactions with Ubiquitin Pathway Enzymes

1998 • 203 citations

Autophagy in Yeast: A Review of the Molecular Machinery.

2002 • 194 citations

The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family

2001 • 188 citations

A Novel Ubiquitin-Specific Protease, UBP43, Cloned from Leukemia Fusion Protein AML1-ETO-Expressing Mice, Functions in Hematopoietic Cell Differentiation

1999 • 158 citations

The Ubiquitin-like Protein FAT10 Forms Covalent Conjugates and Induces Apoptosis

2001 • 157 citations

Dysregulation of protein modification by ISG15 results in brain cell injury

2002 • 156 citations

SUMO: of branched proteins and nuclear bodies

2001 • 152 citations

Structure of GATE-16, Membrane Transport Modulator and Mammalian Ortholog of Autophagocytosis Factor Aut7p

2000 • 143 citations

Targeting of NEDD8 and Its Conjugates for Proteasomal Degradation by NUB1

2001 • 142 citations

Ubiquitin ? protein conjugates

1981 • 113 citations

Regulated SUMOylation and Ubiquitination of DdMEK1 Is Required for Proper Chemotaxis

2002 • 99 citations

Role of a Ubiquitin-Like Modification in Polarized Morphogenesis

2002 • 85 citations

The Rub Family of Ubiquitin-like Proteins

1998 • 83 citations

Proteasomes Modulate Conjugation to the Ubiquitin-like Protein, ISG15

2003 • 80 citations

The Nedd8-conjugated ROC1-CUL1 Core Ubiquitin Ligase Utilizes Nedd8 Charged Surface Residues for Efficient Polyubiquitin Chain Assembly Catalyzed by Cdc34

2002 • 79 citations

A Lack of SUMO Conjugation Affects cNLS-dependent Nuclear Protein Import in Yeast

2002 • 67 citations

The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines

2000 • 48 citations

Ubiquitin-like polypeptide conjugates to acceptor proteins in concanavalin A- and interferon γ-stimulated T-cells

1998 • 19 citations