Immunoreceptor Tyrosine-Based Inhibitory Motif of the IL-4 Receptor Associates with SH2-Containing Phosphatases and Regulates IL-4-Induced Proliferation

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

IL-4/IL-13 signaling beyond JAK/STAT

2000 • 369 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1994 • 306 citations

Human Influence on the Atmospheric Vertical Temperature Structure: Detection and Observations

1996 • 289 citations

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

1987 • 280 citations

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.

1996 • 213 citations

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

1996 • 210 citations

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

1994 • 187 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation

1996 • 180 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction

1998 • 168 citations

Inhibitory receptors, ITIM sequences and phosphatases

1997 • 160 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological functions

2000 • 150 citations

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.

1994 • 144 citations

Stat Proteins Control Lymphocyte Proliferation by Regulating p27^Kip1 Expression

1998 • 133 citations

Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction

2000 • 124 citations

The SHIP phosphatase becomes associated with FcγRIIB1 and is tyrosine phosphorylated during ‘negative’ signaling

1996 • 107 citations

Correction: A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling

1994 • 93 citations

Interleukin 4 signals through two related pathways.

1995 • 90 citations

Negative signaling in B cells: SHIP Grbs Shc

1997 • 81 citations

Regulation of B cell signal transduction by SH2-containing protein–tyrosine phosphatases

1998 • 71 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 64 citations

Regulation of apoptosis by tyrosine-containing domains of IL-4R alpha: Y497 and Y713, but not the STAT6-docking tyrosines, signal protection from apoptosis.

1998 • 59 citations

Interleukin-4 (IL-4) Induces Phosphatidylinositol 3-Kinase (p85) Dephosphorylation

1997 • 56 citations

Immunoreceptor Tyrosine-Based Inhibitory Motifs on Activating Molecules

2000 • 46 citations

Activation-induced bi-dentate interaction of SHIP and Shc in B lymphocytes

1997 • 38 citations

Regulation of Apoptosis by Tyrosine-Containing Domains of IL-4Rα: Y497 and Y713, But Not the STAT6-Docking Tyrosines, Signal Protection from Apoptosis

1998 • 38 citations

Positive Regulation of Interleukin-4-mediated Proliferation by the SH2-containing Inositol-5′-phosphatase

2000 • 32 citations

IL-2, But Not IL-4 and Other Cytokines, Induces Phosphorylation of a 98-kDa Protein Associated with SHP-2, Phosphatidylinositol 3′-Kinase, and Grb2

1999 • 30 citations

Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor α-Chain

2000 • 29 citations

Building up the family of ITIM-bearing negative coreceptors

1996 • 25 citations

Integration of activatory and inhibitory signals in human B-cells

1996 • 22 citations

IL-4 receptor mutations

1999 • 13 citations