Structures of the Cancer-Related Aurora-A, FAK, and EphA2 Protein Kinases from Nanovolume Crystallography

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Oncogenic kinase signalling

2001 • 3,632 citations

Automated protein model building combined with iterative structure refinement.

1999 • 2,428 citations

XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density

1999 • 2,108 citations

Protein kinases — the major drug targets of the twenty-first century?

2002 • 2,101 citations

Molecular classification of cutaneous malignant melanoma by gene expression profiling

2000 • 2,011 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

The Conformational Plasticity of Protein Kinases

2002 • 1,691 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

2002 • 1,349 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.

1995 • 619 citations

Structural basis of cyclin-dependent kinase activation by phosphorylation

1996 • 585 citations

Biochemical signals and biological responses elicited by the focal adhesion kinase

2001 • 568 citations

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

1999 • 542 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

Signaling through focal adhesion kinase

1997 • 468 citations

EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

2001 • 454 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

2000 • 379 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

Structure of GSK3beta reveals a primed phosphorylation mechanism.

2001 • 368 citations

Structural Basis for Autoinhibition of the EphB2 Receptor Tyrosine Kinase by the Unphosphorylated Juxtamembrane Region

2001 • 346 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.

2000 • 319 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Eph receptors and ephrin ligands: embryogenesis to tumorigenesis

2000 • 297 citations

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

2000 • 281 citations

Overexpression of the EphA2 tyrosine kinase in prostate cancer

1999 • 265 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Chemical inhibitors of cyclin-dependent kinases

1996 • 251 citations

E-cadherin regulates the function of the EphA2 receptor tyrosine kinase.

1999 • 248 citations

Design of high-throughput methods of protein production for structural biology

2000 • 240 citations

Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2).

2001 • 240 citations

B61 is a ligand for the ECK receptor protein-tyrosine kinase

1994 • 239 citations

cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases

1990 • 234 citations

High-throughput protein crystallization

2000 • 232 citations

Association of centrosomal kinaseSTK15/BTAK mRNA expression with chromosomal instability in human breast cancers

2001 • 231 citations

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

2002 • 212 citations

Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer

1996 • 201 citations

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1Aresolution

1998 • 198 citations

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

1999 • 196 citations

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

2000 • 192 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

EphrinA1-induced cytoskeletal re-organization requires FAK and p130cas

2002 • 184 citations

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

1990 • 159 citations

cDNA Cloning, Expression, Subcellular Localization, and Chromosomal Assignment of Mammalian Aurora Homologues, Aurora-Related Kinase (ARK) 1 and 2

1998 • 81 citations

Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase

1995 • 65 citations

Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

2002 • 54 citations

Requirement for focal adhesion kinase in tumor cell adhesion

1999 • 53 citations

Chemical Inhibitors of Cyclin-Dependent Kinases

1999 • 40 citations

Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia

2001 • 35 citations