Clock Genes, Oscillators, and Cellular Networks in the Suprachiasmatic Nuclei

Coordination of circadian timing in mammals

2002 • 4,132 citations

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

2002 • 2,248 citations

Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

2000 • 2,232 citations

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

2004 • 2,231 citations

The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

2002 • 2,045 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Entrainment of the Circadian Clock in the Liver by Feeding

2001 • 1,709 citations

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

1995 • 1,437 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus

2003 • 910 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

1997 • 883 citations

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

2001 • 876 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

A transcription factor response element for gene expression during circadian night

2002 • 852 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

1997 • 763 citations

Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections

2001 • 719 citations

A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference

2003 • 712 citations

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

2002 • 701 citations

Dec1 and Dec2 are regulators of the mammalian molecular clock

2002 • 654 citations

Circadian Rhythms in Isolated Brain Regions

2002 • 648 citations

Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency

1994 • 596 citations

The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei

2002 • 541 citations

Toward a detailed computational model for the mammalian circadian clock

2003 • 540 citations

Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity

2002 • 529 citations

Disrupted circadian rhythms in VIP- and PHI-deficient mice

2003 • 381 citations

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

1998 • 376 citations

Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms

2000 • 343 citations

GABA Synchronizes Clock Cells within the Suprachiasmatic Circadian Clock

2000 • 331 citations

The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior

1997 • 291 citations

Circadian Dynamics of Cytosolic and Nuclear Ca2+ in Single Suprachiasmatic Nucleus Neurons

2003 • 268 citations

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

2002 • 267 citations

Temporal Precision in the Mammalian Circadian System: A Reliable Clock from Less Reliable Neurons

2004 • 266 citations

An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center

2003 • 262 citations

Inhibition of Light- or Glutamate-InducedmPer1Expression Represses the Phase Shifts into the Mouse Circadian Locomotor and Suprachiasmatic Firing Rhythms

1999 • 262 citations

The Biological Clock Nucleus: A Multiphasic Oscillator Network Regulated by Light

2003 • 261 citations

Genome-Wide Epistatic Interaction Analysis Reveals Complex Genetic Determinants of Circadian Behavior in Mice

2001 • 244 citations

Role of Molecular Oscillations in Generating Behavioral Rhythms in Drosophila

2001 • 242 citations

Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock

2002 • 241 citations

In Search of the Pathways for Light-Induced Pacemaker Resetting in the Suprachiasmatic Nucleus

2003 • 225 citations

Differential Resynchronisation of Circadian Clock Gene Expression within the Suprachiasmatic Nuclei of Mice Subjected to Experimental Jet Lag

2002 • 217 citations

Requirement of Mammalian Timeless for Circadian Rhythmicity

2003 • 204 citations

Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro

1986 • 186 citations

Cellular communication in the circadian clock, the suprachiasmatic nucleus

1993 • 153 citations

The Suprachiasmatic Nucleus Entrains, But Does Not Sustain, Circadian Rhythmicity in the Olfactory Bulb

2004 • 152 citations

Transcription Regulation within the Circadian Clock: The E-box and Beyond

2004 • 149 citations

The mouse VPAC₂ receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro

2003 • 149 citations

Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: Temperature compensation and damping

2003 • 148 citations

Chimera Analysis of the Clock Mutation in Mice Shows that Complex Cellular Integration Determines Circadian Behavior

2001 • 147 citations

Photic and circadian expression of luciferase in mPeriod1 - luc transgenic mice in vivo

2001 • 137 citations

Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus

2004 • 135 citations

Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons

2002 • 134 citations

Phase Resetting Light Pulses InducePer1and Persistent Spike Activity in a Subpopulation of Biological Clock Neurons

2003 • 133 citations

Resetting the brain clock: time course and localization of mPER1 and mPER2 protein expression in suprachiasmatic nuclei during phase shifts

2004 • 131 citations

Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates

1997 • 130 citations

Finding New Clock Components: Past and Future

2004 • 126 citations

A Novel C-Terminal Domain of Drosophila PERIOD Inhibits dCLOCK:CYCLE-Mediated Transcription

2003 • 125 citations

Gates and Oscillators: A Network Model of the Brain Clock

2003 • 124 citations

Phenotype Matters: Identification of Light-Responsive Cells in the Mouse Suprachiasmatic Nucleus

2004 • 122 citations

Afterhyperpolarization Regulates Firing Rate in Neurons of the Suprachiasmatic Nucleus

2003 • 122 citations

Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice

2002 • 121 citations

DrosophilaPhotoreceptors Contain an Autonomous Circadian Oscillator That Can Function withoutperiodmRNA Cycling

1998 • 118 citations

Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus

2001 • 114 citations

Gastrin-Releasing Peptide Mediates Photic Entrainable Signals to Dorsal Subsets of Suprachiasmatic Nucleus via Induction ofPeriod Gene in Mice

2002 • 113 citations

Olfactory bulb neurons express functional, entrainable circadian rhythms

2004 • 113 citations

Rapid Resetting of the Mammalian Circadian Clock

1999 • 113 citations

Suprachiasmatic Nuclei Grafts Restore the Circadian Rhythm in the Paraventricular Nucleus of the Hypothalamus

2004 • 109 citations

Cycle of period Gene Expression in a Diurnal Mammal (Spermophilus tridecemlineatus): Implications for Nonphotic Phase Shifting

2001 • 105 citations

Aberrant Gating of Photic Input to the Suprachiasmatic Circadian Pacemaker of Mice Lacking the VPAC₂Receptor

2004 • 100 citations

MULTIPLE OSCILLATORS IN THE SUPRACHIASMATIC NUCLEUS

2001 • 71 citations

Dissociation between Circadian Per1 and Neuronal and Behavioral Rhythms Following a Shifted Environmental Cycle

2003 • 69 citations

GABAergic modulation of gap junction communication in slice cultures of the rat suprachiasmatic nucleus

2000 • 61 citations

Neuronal Activity Is Required for the Circadian Rhythm of Vasopressin Gene Transcription in the Suprachiasmatic Nucleusin Vitro

2002 • 58 citations

Electrophysiology of the Circadian Pacemaker in Mammals

2003 • 56 citations

Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons

2000 • 55 citations

A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus

2003 • 52 citations

Light does not degrade the constitutively expressed BMAL1 protein in the mouse suprachiasmatic nucleus

2003 • 49 citations

Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2

2003 • 44 citations

Expression of Clock Gene Products in the Suprachiasmatic Nucleus in Relation to Circadian Behaviour

2003 • 42 citations

Circadian rhythms of arginine vasopressin and vasoactive intestinal polypeptide do not depend on cytoarchitecture of dispersed cell culture of rat suprachiasmatic nucleus

1998 • 40 citations

Restoration of Self-Sustained Circadian Rhythmicity by the Mutant Clock Allele in Mice in Constant Illumination

2002 • 26 citations

A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus

2003 • 20 citations