Human physiological models of insomnia

Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults

1996 • 1,794 citations

The sleep switch: hypothalamic control of sleep and wakefulness

2001 • 1,609 citations

Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications

2001 • 774 citations

Psychophysiological insomnia: the behavioural model and a neurocognitive perspective

1997 • 721 citations

Functional Neuroimaging Evidence for Hyperarousal in Insomnia

2004 • 707 citations

Insomnia in Young Men and Subsequent Depression: The Johns Hopkins Precursors Study

1997 • 687 citations

Adenosine and sleep–wake regulation

2004 • 548 citations

Daytime Alertness in Patients with Chronic Insomnia Compared with Asymptomatic Control Subjects

1988 • 299 citations

Caffeine Use as a Model of Acute and Chronic Insomnia

1992 • 232 citations

Microbial Products and Cytokines in Sleep and Fever Regulation

1994 • 215 citations

The Role of Corticotropin-Releasing Factor in the Pathogenesis of Major Depression

1988 • 181 citations

Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications

2001 • 181 citations

Humoral Links between Sleep and the Immune System

2003 • 156 citations

Depression, sleep, and antidepressants.

1998 • 138 citations

Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia

1995 • 126 citations

Blockade of corticotropin-releasing hormone receptors reduces spontaneous waking in the rat

1998 • 112 citations

Chronic administration of the selective corticotropin-releasing factor 1 receptor antagonist CP-154,526: behavioral, endocrine and neurochemical effects in the rat.

2000 • 101 citations

Effects of triazolam on sleep, daytime sleepiness, and morning stiffness in patients with rheumatoid arthritis.

1996 • 93 citations

Drugs for sleep disorders: mechanisms and therapeutic prospects

2006 • 84 citations

Effects of Sleep Deprivation on Daytime Sleepiness in Primary Insomnia

2000 • 58 citations

Future directions in the management of insomnia.

2001 • 53 citations

The relationship between 6‐sulphatoxymelatonin and polysomnographic sleep in good sleeping controls and wake maintenance insomniacs, aged 55–80 years

1999 • 33 citations

Sleep‐wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus

2004 • 18 citations

Central corticotropin-releasing factor and benzodiazepine receptor systems are involved in the social isolation stress-induced decrease in ethanol sleep in mice

1997 • 18 citations

Evaluation of the efficacy of pivagabine on insomnia associated with mood disorders.

1997 • 4 citations