Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer’s disease: A role for cholinergic transmission

Principles and Practice of Sleep Medicine

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness

1997 • 1,198 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

Dopaminergic Role in Stimulant-Induced Wakefulness

2001 • 763 citations

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

2002 • 699 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

A neural circuit for circadian regulation of arousal

2001 • 600 citations

Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms

2003 • 546 citations

Neuropathologic changes in Alzheimer's disease.

2003 • 544 citations

Neurotransmitters of the hypothalamic suprachiasmatic nucleus: Immunocytochemical analysis of 25 neuronal antigens

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BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

2004 • 529 citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1995 • 521 citations

Principles and Practice of Sleep Medicine

2001 • 488 citations

Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

2002 • 423 citations

Sundowning and Circadian Rhythms in Alzheimer’s Disease

2001 • 363 citations

Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state

2000 • 358 citations

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

2004 • 343 citations

Sleep problems in the community elderly as predictors of death and nursing home placement

1990 • 314 citations

Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains

1990 • 308 citations

β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

1996 • 305 citations

Evidence for glial-mediated inflammation in aged APPSW transgenic mice

1999 • 295 citations

Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex

2004 • 292 citations

Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition

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A role for cryptochromes in sleep regulation.

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Genetic variation in EEG activity during sleep in inbred mice

1998 • 282 citations

Cholinergic function and Alzheimer's disease

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Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice

2001 • 260 citations

Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease

1995 • 227 citations

Progressive and gender-dependent cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease

1999 • 221 citations

Acetylcholine systems and rhythmic activities during the waking–sleep cycle

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Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease

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Sleep and Memory

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Treatment of sleep disturbance in Alzheimer's disease

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Chapter 4 Organization of central cholinergic systems

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Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat

1993 • 154 citations

Adenosine in sleep and wakefulness

1999 • 154 citations

Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence

1996 • 145 citations

The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease

1990 • 131 citations

Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep.

2000 • 125 citations

FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

2002 • 119 citations

Transgenic mice expressing Alzheimer amyloid precursor proteins

1998 • 119 citations

Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice

1991 • 115 citations

Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human β-amyloid precursor protein

2002 • 112 citations

Age-independent and age-related deficits in visuospatial learning, sleep–wake states, thermoregulation and motor activity in PDAPP mice

2002 • 111 citations

Neurotensin-Induced Bursting of Cholinergic Basal Forebrain Neurons Promotes γ and θ Cortical Activity Together with Waking and Paradoxical Sleep

2000 • 109 citations

Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night

1996 • 107 citations

Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type

1986 • 100 citations

Cholinergic neuropathology in a mouse model of Alzheimer's disease

2003 • 99 citations

Alterations in cholinergic and non‐cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with β‐amyloid plaque pathology

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The Effects of a Cholinesterase Inhibitor Are Prominent in Patients With Fluctuating Cognition: A Part 3 Study of the Main Mechanism of Cholinesterase Inhibitors in Dementia

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Real-Time Automated Sleep Scoring: Validation of a Microcomputer-Based System for Mice

1991 • 67 citations

Different manifestations of circadian rhythms in senile dementia of Alzheimer's type and multi-infarct dementia

1997 • 64 citations

Molecular features of hypothalamic plaques in Alzheimer's disease.

1991 • 60 citations

Sleep in Alzheimer's disease and other dementing disorders.

1991 • 59 citations

Disruption of circadian regulation by brain grafts that overexpress Alzheimer beta/A4 amyloid.

1992 • 52 citations

Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls

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Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology

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Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Aβ

2003 • 48 citations

Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders.

1994 • 44 citations

Muscarinic receptors mediate carbachol-induced phase shifts of circadian activity rhythms in Syrian hamsters

1996 • 43 citations

β-Amyloid(1-42)-Induced Cholinergic Lesions in Rat Nucleus Basalis Bidirectionally Modulate Serotonergic Innervation of the Basal Forebrain and Cerebral Cortex

2001 • 42 citations

β‐Amyloid Excitotoxicity in Rat Magnocellular Nucleus Basalis: Effect of Cortical Deafferentation on Cerebral Blood Flow Regulation and Implications for Alzheimer's Disease

2000 • 42 citations

Apolipoprotein E deposition and astrogliosis are associated with maturation of β-amyloid plaques in βAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer’s disease

2001 • 36 citations

The human suprachiasmatic nucleus; neuropeptide changes in senium and Alzheimer's disease.

1988 • 36 citations

The effects of an orally administered cholinergic agonist on REM sleep in major depression

2002 • 34 citations

Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats

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Free-running period of circadian rhythms is shorter in rats with a genetically upregulated central cholinergic system

1994 • 29 citations

The nature and management of sleep/wake disturbance in Alzheimer's dementia.

1988 • 28 citations

Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer?s disease

2004 • 27 citations

EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos

2002 • 19 citations

Acetylcholine in the Cerebral Cortex

2004 • 12 citations

Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats

2001 • 11 citations

Disorders of the Circadian Clock: Etiology and Possible Therapeutic Targets

2002 • 11 citations