The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
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Abstract
References (106)
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Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine
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Fos Expression in Orexin Neurons Varies with Behavioral State
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Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
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Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine
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2002 • 459 citations
The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms
2006 • 455 citations
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2004 • 445 citations
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Hypocretins (Orexins) Regulate Serotonin Neurons in the Dorsal Raphe Nucleus by Excitatory Direct and Inhibitory Indirect Actions
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Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal
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Convergent Excitation of Dorsal Raphe Serotonin Neurons by Multiple Arousal Systems (Orexin/Hypocretin, Histamine and Noradrenaline)
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Attenuated defense response and low basal blood pressure in orexin knockout mice
2003 • 338 citations
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
2004 • 334 citations
Independent Feeding and Metabolic Actions of Orexins in Mice
1998 • 325 citations
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
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Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin NeuronsIn Situ
2005 • 320 citations
Selective Activation of the Extended Ventrolateral Preoptic Nucleus during Rapid Eye Movement Sleep
2002 • 314 citations
Orexins/hypocretins excite basal forebrain cholinergic neurones
2001 • 307 citations
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
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1989 • 295 citations
Tandem-Pore K+ Channels Mediate Inhibition of Orexin Neurons by Glucose
2006 • 293 citations
Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor
2002 • 292 citations
Topographic organization of suprachiasmatic nucleus projection neurons
2001 • 286 citations
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker
2006 • 286 citations
Centrally administered orexin/hypocretin activates HPA axis in rats
2000 • 280 citations
Orexin-induced food intake involves neuropeptide Y pathway
2000 • 262 citations
Mind versus metabolism in the control of food intake and energy balance
2004 • 254 citations
Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep
1992 • 241 citations
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus
2004 • 234 citations
Regulation of orexin neurons by the monoaminergic and cholinergic systems
2003 • 222 citations
Hypoglycemia Activates Orexin Neurons and Selectively Increases Hypothalamic Orexin-B Levels
2001 • 211 citations
Orexin Neurons Function in an Efferent Pathway of a Food-Entrainable Circadian Oscillator in Eliciting Food-Anticipatory Activity and Wakefulness
2004 • 205 citations
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions
2005 • 197 citations
Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat
2001 • 190 citations
Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1AReceptor
2004 • 190 citations
Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect
2006 • 186 citations
Inhibition of Food Intake by Central Injection of Anti-orexin Antibody in Fasted Rats
2000 • 186 citations
Reduced food anticipatory activity in genetically orexin (hypocretin) neuron‐ablated mice
2004 • 184 citations
Orexin A in the nucleus accumbens stimulates feeding and locomotor activity
2005 • 184 citations
Neuropeptide Y Inhibits Hypocretin/Orexin Neurons by Multiple Presynaptic and Postsynaptic Mechanisms: Tonic Depression of the Hypothalamic Arousal System
2004 • 175 citations
Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysis
1999 • 169 citations
Orexin Receptor Type-1 Couples Exclusively to Pertussis Toxin-Insensitive G-Proteins, While Orexin Receptor Type-2 Couples to Both Pertussis Toxin-Sensitive and -Insensitive G-Proteins
2003 • 165 citations
Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons
2004 • 151 citations
Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion
2003 • 149 citations
Cholecystokinin Activates Orexin/Hypocretin Neurons through the Cholecystokinin A Receptor
2005 • 141 citations
Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice
2002 • 141 citations
The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions
2006 • 133 citations
Activation of a subpopulation of orexin/hypocretin‐containing hypothalamic neurons by GABAA receptor‐mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment
2004 • 130 citations
Orexin Neurons Are Directly and Indirectly Regulated by Catecholamines in a Complex Manner
2006 • 120 citations
Glucagon-Like Peptide 1 Excites Hypocretin/Orexin Neurons by Direct and Indirect Mechanisms: Implications for Viscera-Mediated Arousal
2004 • 118 citations
Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
2005 • 112 citations
Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro
2006 • 109 citations
GABAB receptor‐mediated modulation of hypocretin/orexin neurones in mouse hypothalamus
2006 • 103 citations
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
2006 • 103 citations
On the Treatment of Rapid Eye Movement Narcolepsy
1974 • 101 citations
Distribution of Choline Acetyltransferase Immunoreactive Somata in the Feline Brainstem: Implications for REM Sleep Generation
1988 • 93 citations
Roles of Orexins and Orexin Receptors in Central Regulation of Feeding Behavior and Energy Homeostasis
2006 • 86 citations
Effects of orexin on the laterodorsal tegmental neurones
2002 • 75 citations
Genetic Studies in the Sleep Disorder Narcolepsy
1998 • 67 citations
The Wake-Promoting Hypocretin/Orexin Neurons Change Their Response to Noradrenaline after Sleep Deprivation
2005 • 66 citations
Direct Excitation of Hypocretin/Orexin Cells by Extracellular ATP at P2X Receptors
2005 • 61 citations
Neuroanatomy
1997 • 56 citations
Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats
1997 • 44 citations
Neuronal interactions between galanin-like-peptide- and orexin- or melanin-concentrating hormone-containing neurons
2004 • 44 citations
Neuropharmacological Characterization of Basal Forebrain Cholinergic Stimulated Cataplexy in Narcoleptic Canines
1998 • 40 citations
Effects of 24-Hr fasting on methamphetamine- and apomorphine-induced locomotor activities, and on monoamine metabolism in mouse corpus striatum and nucleus accumbens
1990 • 19 citations
Deleted Work
1955 • 0 citations