TCR transgenic CD8+ T cells activated in the presence of TGF express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Improved technique of heart transplantation in rats

1969 • 1,338 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

2004 • 1,123 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Type 1 T regulatory cells

2001 • 829 citations

Infectious immunological tolerance.

1971 • 811 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System

2005 • 545 citations

TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

2004 • 527 citations

Induction offoxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants

2004 • 416 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.

1976 • 363 citations

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

2005 • 339 citations

Suppressor Cells and Immunoregulation

1984 • 337 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells

2003 • 308 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses.

1976 • 279 citations

Specific suppression of T helper alloreactivity by allo-MHC class I- restricted CD8+CD28- T cells

1998 • 271 citations

Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3

2004 • 265 citations

Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐β

1992 • 250 citations

Signal transduction by cell adhesion receptors

1995 • 239 citations

Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium.

1988 • 234 citations

Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation

2004 • 198 citations

Tregs and transplantation tolerance

2004 • 195 citations

Development of a Novel Transgenic Mouse for the Study of Interactions Between CD4 and CD8 T Cells During Graft Rejection

2003 • 189 citations

Lymph Node Occupancy Is Required for the Peripheral Development of Alloantigen-Specific Foxp3+ Regulatory T Cells

2005 • 182 citations

Regulatory T cells and organ transplantation

2004 • 177 citations

Linked suppression of skin graft rejection can operate through indirect recognition.

1998 • 175 citations

Characterization of suppressor cells in anterior chamber-associated immune deviation (ACAID) induced by soluble antigen. Evidence of two functionally and phenotypically distinct T-suppressor cell populations.

1990 • 172 citations

A novel technique for the fluorometric assessment of T lymphocyte antigen specific lysis

2001 • 166 citations

Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance.

1987 • 166 citations

T-Cell Costimulatory Pathways in Allograft Rejection and Tolerance

2005 • 120 citations

Rat CD8+ FOXP3+ T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection

2004 • 104 citations

Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells: review

2004 • 104 citations

Induction and Measurement of Cytotoxic T Lymphocyte Activity

2018 • 85 citations

Systemic Transforming Growth Factor-??1 Gene Therapy Induces Foxp3+ Regulatory Cells, Restores Self-Tolerance, and Facilitates Regeneration Of Beta Cell Function in Overtly Diabetic Nonobese Diabetic Mice

2005 • 83 citations

Detection of T suppressor cells in patients with organ allografts

2001 • 81 citations

Differential activation of CD8+ T cells by transforming growth factor-beta 1.

1993 • 77 citations

Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases.

2005 • 75 citations

Transforming growth factor beta 1 costimulated growth and regulatory function of staphylococcal enterotoxin B-responsive CD8+ T cells.

1995 • 61 citations

Induction of transplantation tolerance—the potential of regulatory T cells

2005 • 60 citations

Dendritic cell elimination as an assay of cytotoxic T lymphocyte activity in vivo

2000 • 58 citations

Quantitation of HIV-1 by real-time PCR with a unique fluorogenic probe

2001 • 54 citations

Self-tolerance and localized autoimmunity

1990 • 52 citations

In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation.

2000 • 52 citations

Visualization of naturally occurring Foxp3+ regulatory T cells in normal and tumor-bearing mice

2004 • 40 citations

Haplotype‐specific suppressor T cells mediating linked suppression of immune responses elicited by third‐party H‐2 alloantigens

1983 • 39 citations

NFκB-Inducing Kinase Deficiency Results in the Development of a Subset of Regulatory T Cells, which Shows a Hyperproliferative Activity upon Glucocorticoid-Induced TNF Receptor Family-Related Gene Stimulation

2005 • 35 citations

Human liver allograft acceptance and the “tolerance assay”

2002 • 34 citations

Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells.

2004 • 33 citations

Evidence for Cooperativity in the Rejection of Cardiac Grafts Mediated by CD4+ TCR Tg T Cells Specific for a Defined Allopeptide

2004 • 29 citations

Alloantigen-specific suppressor T cells are not inhibited by cyclosporin A, but do require IL 2 for activation.

1986 • 26 citations

Transforming Growth Factor‐Beta1 Gene Transfer is Associated with the Development of Regulatory Cells

2005 • 23 citations

TGF-β signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions

2005 • 15 citations

Activation and migration of allo-peptide specific TCR transgenic T cells in cardiac allograft rejection

2004 • 14 citations

The effects of immunosuppressive pharmacological agents on the induction of cytotoxic and suppressor T lymphocytes in vitro

1988 • 9 citations

Stability in the HIV vDNA pool in peripheral CD4+ T cells of untreated patients by single tube quantitative PCR

2000 • 8 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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