Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

2003 • 1,267 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

2002 • 800 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Generation of Human CD8 T Regulatory Cells by CD40 Ligand–activated Plasmacytoid Dendritic Cells

2002 • 659 citations

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

2001 • 650 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Control of T‐cell activation by CD4⁺ CD25⁺ suppressor T cells

2001 • 560 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets

1996 • 320 citations

Virus-specific CD8+ T Lymphocytes Downregulate T Helper Cell Type 2 Cytokine Secretion and Pulmonary Eosinophilia during Experimental Murine Respiratory Syncytial Virus Infection

1997 • 286 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

1999 • 269 citations

Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

2003 • 262 citations

CD4+ regulatory T cells

2001 • 241 citations

Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4⁺ T cells

1991 • 218 citations

CD8+ T cells can be primed in vitro to produce IL-4.

1992 • 214 citations

Autoreactive CD8 T Cells in Organ-Specific Autoimmunity

2002 • 204 citations

Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans.

1993 • 195 citations

Subsets of CD4⁺ T Cells and their Roles in the Induction and Prevention of Autoimmunity

1991 • 174 citations

CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

1997 • 171 citations

The Specific Regulation Of Immune Responses By CD8⁺T Cells Restricted By The MHC Class Ib Molecule, Qa-1

2000 • 168 citations

Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes

2000 • 153 citations

Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.

1996 • 137 citations

Heterogeneity in Lymphokine Profiles of CD4⁺ and CD8⁺ T Cells and Clones Activated in vivo and in vitro

1991 • 132 citations

The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype.

1989 • 125 citations

The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset

1996 • 121 citations

Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID) induced in BALB/c mice by P815 cells.

1985 • 118 citations

Virus-specific CD8+ T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection

2001 • 100 citations

Suppression of Immune Responses by CD8 Cells. II. Qa-1 on Activated B Cells Stimulates CD8 Cell Suppression of T Helper 2 Responses

1998 • 98 citations

Regulatory T cells: mediating compromises between host and parasite

2002 • 86 citations

Distinction of mouse CD8+ suppressor effector T cell clones from cytotoxic T cell clones by cytokine production and CD45 isoforms.

1993 • 73 citations

Alloreactive CD4 T lymphocytes responsible for acute and chronic graft‐versus‐host disease are contained within the CD45RC^high but not the CD45RC^low subset

2004 • 72 citations

Depletion of CD8⁺ T cells suppresses the development of experimental autoimmune myasthenia gravis in Lewis rats

1995 • 64 citations

CD4⁺CD25⁺ regulatory cells in acquired MHC tolerance

2001 • 43 citations

Regulation of Experimental Autoimmune Encephalomyelitis (EAE) by CD4 ⁺ CD25 ⁺ Regulatory T Cells

2003 • 42 citations

The CD8 T Cell Compartment Plays a Dominant Role in the Deficiency of Brown-Norway Rats to Mount a Proper Type 1 Immune Response

2002 • 22 citations

Depletion of CD8+ T Cells following Primary Immunization with Ovalbumin Results in a High and Persistent IgE Response

1997 • 13 citations

Flow cytometric analysis of intracellular interferon-gamma synthesis in rat CD4 T cells.

1998 • 8 citations

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