Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement

Transport Between the Cell Nucleus and the Cytoplasm

1999 • 2,001 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

1998 • 1,634 citations

Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery

2003 • 1,470 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

Structure of TPR Domain–Peptide Complexes

2000 • 1,159 citations

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

2000 • 971 citations

Identification of CHIP, a Novel Tetratricopeptide Repeat-Containing Protein That Interacts with Heat Shock Proteins and Negatively Regulates Chaperone Functions

1999 • 904 citations

Molecular Chaperones Hsp90 and Hsp70 Deliver Preproteins to the Mitochondrial Import Receptor Tom70

2003 • 836 citations

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1998 • 820 citations

The Glucocorticoid Receptor: Rapid Exchange with Regulatory Sites in Living Cells

2000 • 791 citations

Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

2001 • 664 citations

Overexpression of the Dynamitin (p50) Subunit of the Dynactin Complex Disrupts Dynein-dependent Maintenance of Membrane Organelle Distribution

1997 • 652 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and Dyneins

2000 • 544 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

A New First Step in Activation of Steroid Receptors

2002 • 418 citations

A Novel Cytoplasmic Protein That Interacts with the Ah Receptor, Contains Tetratricopeptide Repeat Motifs, and Augments the Transcriptional Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1997 • 414 citations

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

1999 • 411 citations

Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homolog in Vivo

1997 • 410 citations

Nopp 140 shuttles on tracks between nucleolus and cytoplasm

1992 • 409 citations

Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones

2002 • 402 citations

FRAP reveals that mobility of oestrogen receptor-α is ligand- and proteasome-dependent

2000 • 390 citations

Chaperone Function of Hsp90-Associated Proteins

1996 • 376 citations

Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.

1996 • 376 citations

Hepatitis B Virus X-Associated Protein 2 Is a Subunit of the Unliganded Aryl Hydrocarbon Receptor Core Complex and Exhibits Transcriptional Enhancer Activity

1998 • 375 citations

Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

1996 • 371 citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 • 367 citations

Peptidylprolyl Cis / Trans Isomerases (Immunophilins): Biological Diversity - Targets - Functions

2003 • 358 citations

Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons

1996 • 356 citations

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

2000 • 352 citations

Loss, Restoration, and Maintenance of Plasma Membrane Integrity

1997 • 341 citations

The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

2003 • 340 citations

The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

1992 • 335 citations

Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG

2003 • 314 citations

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

1996 • 309 citations

Squirrel Monkey Immunophilin FKBP51 Is a Potent Inhibitor of Glucocorticoid Receptor Binding¹

2000 • 293 citations

Dynamics of Intracellular Movement and Nucleocytoplasmic Recycling of the Ligand-Activated Androgen Receptor in Living Cells

2000 • 283 citations

Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor

1998 • 275 citations

Mechanisms of Fast and Slow Axonal Transport

1991 • 269 citations

Calreticulin Is a Receptor for Nuclear Export

2001 • 269 citations

Protein Phosphatase 5 Is a Major Component of Glucocorticoid Receptor·hsp90 Complexes with Properties of an FK506-binding Immunophilin

1997 • 264 citations

Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery

1997 • 260 citations

Direct Visualization of the Human Estrogen Receptor α Reveals a Role for Ligand in the Nuclear Distribution of the Receptor

1999 • 258 citations

p53

2002 • 249 citations

Subcellular localization of mineralocorticoid receptors in living cells: Effects of receptor agonists and antagonists

1998 • 247 citations

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

2003 • 245 citations

Role of the Myosin Assembly Protein UNC-45 as a Molecular Chaperone for Myosin

2002 • 245 citations

Overexpression of the FK506-Binding Immunophilin FKBP51 Is the Common Cause of Glucocorticoid Resistance in Three New World Primates

2001 • 241 citations

Evidence That the Peptidylprolyl Isomerase Domain of the hsp90-binding Immunophilin FKBP52 Is Involved in Both Dynein Interaction and Glucocorticoid Receptor Movement to the Nucleus

2001 • 240 citations

The Human Peroxisomal Targeting Signal Receptor, Pex5p, Is Translocated into the Peroxisomal Matrix and Recycled to the Cytosol

2001 • 237 citations

Subnuclear Trafficking of Estrogen Receptor-α and Steroid Receptor Coactivator-1

2000 • 233 citations

Ligand Discrimination by TPR Domains

2002 • 229 citations

Specific Binding of Tetratricopeptide Repeat Proteins to the C-terminal 12-kDa Domain of hsp90

1998 • 228 citations

Characterization of the AhR−hsp90−XAP2 Core Complex and the Role of the Immunophilin-Related Protein XAP2 in AhR Stabilization

1999 • 226 citations

Discrimination between NL1- and NL2-Mediated Nuclear Localization of the Glucocorticoid Receptor

1999 • 224 citations

Dynamic behavior of transcription factors on a natural promoter in living cells

2002 • 214 citations

Characterization of the Ah Receptor-associated Protein, ARA9

1998 • 204 citations

Regulation of Estrogen Receptor Nuclear Export by Ligand-Induced and p38-Mediated Receptor Phosphorylation

2002 • 201 citations

The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor

2001 • 197 citations

Different Regions of the Immunophilin FKBP52 Determine Its Association with the Glucocorticoid Receptor, hsp90, and Cytoplasmic Dynein

1999 • 190 citations

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

1998 • 190 citations

Nucleocytoplasmic transport: cargo trafficking across the border

2002 • 188 citations

Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

1990 • 187 citations

Glucocorticoid Resistance in the Squirrel Monkey Is Associated with Overexpression of the Immunophilin FKBP51¹

1999 • 187 citations

Folding of the Glucocorticoid Receptor by the Reconstituted hsp90-based Chaperone Machinery

1997 • 183 citations

Analysis of FKBP51/FKBP52 Chimeras and Mutants for Hsp90 Binding and Association with Progesterone Receptor Complexes

1998 • 180 citations

Functional analysis of the hsp90-associated human peptidyl prolyl Cis/Trans isomerases FKBP51, FKBP52 and cyp40 1 1Edited by R. Huber

2001 • 178 citations

Dynamic Remodeling of Transcription Complexes by Molecular Chaperones

2002 • 176 citations

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.

1992 • 176 citations

The Immunophilin-like Protein XAP2 Regulates Ubiquitination and Subcellular Localization of the Dioxin Receptor

2000 • 174 citations

Heat Shock Protein 90-Dependent (Geldanamycin-Inhibited) Movement of the Glucocorticoid Receptor through the Cytoplasm to the Nucleus Requires Intact Cytoskeleton

1998 • 173 citations

The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor

1995 • 172 citations

Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence.

1990 • 170 citations

An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.

1992 • 168 citations

Mechanism of Antiandrogen Action: Key Role of Hsp90 in Conformational Change and Transcriptional Activity of the Androgen Receptor

2002 • 167 citations

Regulation of Nuclear Localization during Signaling

2001 • 165 citations

A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37

1999 • 165 citations

The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies

2000 • 165 citations

Identification and Characterization of a Ligand-regulated Nuclear Export Signal in Androgen Receptor

2003 • 163 citations

A Model of Protein Targeting Mediated by Immunophilins and Other Proteins That Bind to hsp90 via Tetratricopeptide Repeat Domains

1996 • 163 citations

Identification of Conserved Residues Required for the Binding of a Tetratricopeptide Repeat Domain to Heat Shock Protein 90

1999 • 158 citations

Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import

1996 • 157 citations

SBA1 Encodes a Yeast Hsp90 Cochaperone That Is Homologous to Vertebrate p23 Proteins

1998 • 154 citations

Protein phosphatase 5 in signal transduction

2001 • 151 citations

Dimerization with Retinoid X Receptors Promotes Nuclear Localization and Subnuclear Targeting of Vitamin D Receptors

2000 • 149 citations

Differential Localization and Activity of the A- and B-Forms of the Human Progesterone Receptor Using Green Fluorescent Protein Chimeras

1999 • 149 citations

Geldanamycin, a Heat Shock Protein 90-Binding Benzoquinone Ansamycin, Inhibits Steroid-Dependent Translocation of the Glucocorticoid Receptor from the Cytoplasm to the Nucleus

1997 • 146 citations

Mitogen-Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors

2003 • 138 citations

Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin.

1993 • 137 citations

ATP-Dependent Mobilization of the Glucocorticoid Receptor during Chromatin Remodeling

2002 • 137 citations

Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain

1997 • 135 citations

The Subnuclear Three-dimensional Image Analysis of Androgen Receptor Fused to Green Fluorescence Protein

2001 • 135 citations

Immunophilin Chaperones in Steroid Receptor Signalling

2003 • 135 citations

Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system

2003 • 131 citations

Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90

1993 • 130 citations

Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus

1995 • 130 citations

Androgen Receptor Acetylation Site Mutations Cause Trafficking Defects, Misfolding, and Aggregation Similar to Expanded Glutamine Tracts

2004 • 128 citations

Trafficking of nuclear receptors in living cells

2000 • 127 citations

Nucleocytoplasmic Trafficking of Steroid-free Glucocorticoid Receptor

1999 • 126 citations

Ser/Thr Protein Phosphatase Type 5 (PP5) Is a Negative Regulator of Glucocorticoid Receptor-Mediated Growth Arrest

1999 • 126 citations

An FK506-sensitive Transporter Selectively Decreases Intracellular Levels and Potency of Steroid Hormones

1996 • 125 citations

In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus.

1994 • 125 citations

Hormone-induced Translocation of Thyroid Hormone Receptors in Living Cells Visualized Using a Receptor Green Fluorescent Protein Chimera

1998 • 124 citations

Role for Hsp90-Associated Cochaperone p23 in Estrogen Receptor Signal Transduction

1999 • 122 citations

ARA9 Modifies Agonist Signaling through an Increase in Cytosolic Aryl Hydrocarbon Receptor

2000 • 122 citations

p50 Binds Directly to the Catalytic Domain of Raf as Well as to a Site on hsp90 That Is Topologically Adjacent to the Tetratricopeptide Repeat Binding Site

1998 • 119 citations

Binding of hsp90-Associated Immunophilins to Cytoplasmic Dynein: Direct Binding and in Vivo Evidence that the Peptidylprolyl Isomerase Domain Is a Dynein Interaction Domain

2002 • 119 citations

Heat Shock Protein 84 Forms a Complex with Mutant p53 Protein Predominantly within a Cytoplasmic Compartment of the Cell

1996 • 117 citations

The hsp90 Co-chaperone XAP2 Alters Importin β Recognition of the Bipartite Nuclear Localization Signal of the Ah Receptor and Represses Transcriptional Activity

2003 • 114 citations

Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.

1994 • 114 citations

The Common Tetratricopeptide Repeat Acceptor Site for Steroid Receptor-associated Immunophilins and Hop Is Located in the Dimerization Domain of Hsp90

1999 • 112 citations

Molecular Mechanism of Nuclear Translocation of an Orphan Nuclear Receptor, SXR

2003 • 112 citations

Evidence That Peroxisome Proliferator-activated Receptor α Is Complexed with the 90-kDa Heat Shock Protein and the Hepatitis Virus B X-associated Protein 2

2003 • 110 citations

Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import

2001 • 110 citations

Navigating Steroid Hormone Receptors through the Nuclear Compartment

2002 • 108 citations

Subcellular Localization of the Aryl Hydrocarbon Receptor Is Modulated by the Immunophilin Homolog Hepatitis B Virus X-associated Protein 2

2000 • 106 citations

Dynamic Changes in Subcellular Localization of Mineralocorticoid Receptor in Living Cells: In Comparison with Glucocorticoid Receptor using Dual-Color Labeling with Green Fluorescent Protein Spectral Variants

2001 • 106 citations

Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins

1998 • 105 citations

Hsp90-binding immunophilins in plants: the protein movers

2001 • 104 citations

C-terminal Sequences outside the Tetratricopeptide Repeat Domain of FKBP51 and FKBP52 Cause Differential Binding to Hsp90

2003 • 100 citations

Protracted Nuclear Export of Glucocorticoid Receptor Limits Its Turnover and Does Not Require the Exportin 1/CRM1-Directed Nuclear Export Pathway

2000 • 99 citations

Inhibition of Glucocorticoid Receptor Nucleocytoplasmic Shuttling by Okadaic Acid Requires Intact Cytoskeleton

1999 • 98 citations

Chromatin Recycling of Glucocorticoid Receptors: Implications for Multiple Roles of Heat Shock Protein 90

1999 • 97 citations

Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression.

1995 • 96 citations

The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex

2003 • 94 citations

Structure and Dynamic Properties of a Glucocorticoid Receptor-Induced Chromatin Transition

2000 • 90 citations

Nucleocytoplasmic Shuttling of Steroid Receptors

1995 • 85 citations

Identification of Potential Physiological Activators of Protein Phosphatase 5

2002 • 83 citations

The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor.

1994 • 82 citations

Continuous recycling: a mechanism for modulatory signal transduction

2001 • 80 citations

Hsp90 Interactions and Acylation Target the G Protein Gα12 but Not Gα13 to Lipid Rafts

2002 • 80 citations

Binding of Immunophilins to the 90 kDa Heat Shock Protein (hsp90) via a Tetratricopeptide Repeat Domain Is a Conserved Protein Interaction in Plants

1996 • 79 citations

Diffusional protein transport within the nucleus: a message in the medium

2000 • 79 citations

Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2

2002 • 78 citations

ATP-Dependent Release of Glucocorticoid Receptors from the Nuclear Matrix

1996 • 77 citations

The Tetratricopeptide Repeat Domain and a C-terminal Region Control the Activity of Ser/Thr Protein Phosphatase 5

1999 • 77 citations

Overlapping Sites of Tetratricopeptide Repeat Protein Binding and Chaperone Activity in Heat Shock Protein 90

2000 • 75 citations

The Effects of Chaperones and the Influence of Protein Assembly on Peroxisomal Protein Import

1998 • 72 citations

Demonstration by Confocal Microscopy that Unliganded Overexpressed Glucocorticoid Receptors are Distributed in a Nonrandom Manner throughout All Planes of the Nucleus

1991 • 72 citations

Protein dynamics in the nuclear compartment

2002 • 71 citations

Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling.

2001 • 70 citations

The hsp56 immunophilin component of steroid receptor heterocomplexes: Could this be the elusive nuclear localization signal-binding protein?

1993 • 67 citations

Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody.

1992 • 66 citations

Subcellular distribution of the glucocorticoid receptor and evidence for its association with microtubules

1995 • 65 citations

High-Molecular-Weight FK506-Binding Proteins Are Components of Heat-Shock Protein 90 Heterocomplexes in Wheat Germ Lysate

1998 • 63 citations

A Structure-based Mutational Analysis of Cyclophilin 40 Identifies Key Residues in the Core Tetratricopeptide Repeat Domain That Mediate Binding to Hsp90

2002 • 63 citations

Kinetics of glucocorticoid-receptor complexes in rat thymus cells

1976 • 62 citations

The 59 kDa FK506-binding protein, a 90 kDa heat shock protein binding immunophilin (FKBP59-HBI), is associated with the nucleus, the cytoskeleton and mitotic apparatus

1995 • 60 citations

Molecular chaperones and subcellular trafficking of steroid receptors

1998 • 60 citations

Interaction between the Gα Subunit of Heterotrimeric G12 Protein and Hsp90 Is Required for Gα12 Signaling

2001 • 60 citations

Two Distinct Regions of the Immunophilin-like Protein XAP2 Regulate Dioxin Receptor Function and Interaction with hsp90

2002 • 59 citations

Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1

2001 • 58 citations

Recognition of Peroxisomal Targeting Signal Type 1 by the Import Receptor Pex5p

2001 • 57 citations

Region-Specific Antiglucocorticoid Receptor Antibodies Selectively Recognize the Activated Form of the Ligand-Occupied Receptor and Inhibit the Binding of Activated Complexes to Deoxyribonucleic Acid

1989 • 57 citations

All of the Protein Interactions That Link Steroid Receptor·Hsp90·Immunophilin Heterocomplexes to Cytoplasmic Dynein Are Common to Plant and Animal Cells

2002 • 53 citations

Regulation of steroid receptor subcellular trafficking

1999 • 52 citations

Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1

2001 • 51 citations

Potentiation of Progesterone Receptor-Mediated Transcription by the Immunosuppressant FK506

1994 • 51 citations

Role of molecular chaperones in subnuclear trafficking of glucocorticoid receptors

2000 • 51 citations

A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex

1992 • 49 citations

Intracellular localization and trafficking of steroid receptors

1999 • 44 citations

Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor

1994 • 43 citations

Intracellular Retention and Degradation of the Epidermal Growth Factor Receptor, Two Distinct Processes Mediated by Benzoquinone Ansamycins

2000 • 43 citations

Recycling and Desensitization of Glucocorticoid Receptors in v-mosTransformed Cells Depend on the Ability of Nuclear Receptors to Modulate Gene Expression

1990 • 42 citations

Two Parallel Pathways Mediate Cytoplasmic Localization of the Dioxin (Aryl Hydrocarbon) Receptor

2002 • 41 citations

Genetic Dissection of p23, an Hsp90 Cochaperone, Reveals a Distinct Surface Involved in Estrogen Receptor Signaling

2003 • 39 citations

Cloning and Expression of the Glucocorticoid Receptor from the Squirrel Monkey (Saimiri boliviensis boliviensis), a Glucocorticoid-Resistant Primate¹

1997 • 38 citations

Yellow Fluorescent Protein-Tagged and Cyan Fluorescent Protein-Tagged Imaging Analysis of Glucocorticoid Receptor and Importins in Single Living Cells

2003 • 36 citations

Stabilization in vitro of the untransformed glucocorticoid receptor complex of S49 lymphocytes by the immunophilin ligand FK506

1995 • 34 citations

Steroid Receptor and Molecular Chaperone Encounters in the Nucleus

2000 • 21 citations

Tetratricopeptide repeat domain of Yarrowia lipolytica Pex5p is essential for recognition of the type 1 peroxisomal targeting signal but does not confer full biological activity on Pex5p

2000 • 18 citations

Peroxin Puzzles and Folded Freight: Peroxisomal Protein Import in Review

1999 • 18 citations

Chaperones and transcriptional regulation by nuclear receptors

2002 • 15 citations

Impaired transactivation of the glucocorticoid receptor cloned from the Guyanese squirrel monkey

2000 • 15 citations