Recognition of Peroxisomal Targeting Signal Type 1 by the Import Receptor Pex5p

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Molecular cloning: A laboratory manual

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Structure of TPR Domain–Peptide Complexes

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A conserved tripeptide sorts proteins to peroxisomes.

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1992 • 531 citations

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The TPR snap helix: a novel protein repeat motif from mitosis to transcription

1991 • 452 citations

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1991 • 441 citations

Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders

1995 • 430 citations

Pex14p, a Peroxisomal Membrane Protein Binding Both Receptors of the Two PTS-Dependent Import Pathways

1997 • 318 citations

Structure of the TPR Domain of p67phox in Complex with Rac·GTP

2000 • 300 citations

PAS7 encodes a novel yeast member of the WD-40 protein family essential for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into peroxisomes.

1994 • 295 citations

Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor.

1996 • 248 citations

The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 246 citations

Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase

1991 • 243 citations

Import of Peroxisomal Matrix and Membrane Proteins

2000 • 233 citations

Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor.

1996 • 225 citations

The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.

1996 • 224 citations

The Difference in Recognition of Terminal Tripeptides as Peroxisomal Targeting Signal 1 between Yeast and Human Is Due to Different Affinities of Their Receptor Pex5p to the Cognate Signal and to Residues Adjacent to It

1998 • 202 citations

Peroxisome Targeting Signal Type 1 (PTS1) Receptor Is Involved in Import of Both PTS1 and PTS2: Studies with PEX5-Defective CHO Cell Mutants

1998 • 200 citations

Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene.

1995 • 190 citations

Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.

1995 • 187 citations

The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal.

1995 • 178 citations

Identification and Characterization of the Putative Human Peroxisomal C-terminal Targeting Signal Import Receptor

1995 • 176 citations

Recombinant Human Peroxisomal Targeting Signal Receptor PEX5

1999 • 173 citations

Involvement of Pex13p in Pex14p Localization and Peroxisomal Targeting Signal 2–dependent Protein Import into Peroxisomes

1999 • 172 citations

Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence.

1996 • 167 citations

Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo.

1994 • 160 citations

Analysis of the Carboxyl-terminal Peroxisomal Targeting Signal 1 in a Homologous Context in Saccharomyces cerevisiae

1996 • 158 citations

Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import

1998 • 156 citations

Pex17p of Saccharomyces cerevisiae Is a Novel Peroxin and Component of the Peroxisomal Protein Translocation Machinery

1998 • 151 citations

Mutational analysis of the N-terminal topogenic signal of watermelon glyoxysomal malate dehydrogenase using the heterologous host Hansenula polymorpha.

1994 • 149 citations

The Tetratricopeptide Repeat Domain of the PAS10 Protein of Saccharomyces cerevisiae Is Essential for Binding the Peroxisomal Targeting Signal -SKL

1994 • 147 citations

PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-peroxisomal protein that is a member of the WD repeat family and is essential for the import of thiolase into peroxisomes.

1995 • 140 citations

Import of proteins into peroxisomes

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Targeting efficiencies of various permutations of the consensus C‐terminal tripeptide peroxisomal targeting signal

1992 • 130 citations

Pex14p is a member of the protein linkage map of Pex5p

1997 • 126 citations

Saccharomyces cerevisiaePTS1 Receptor Pex5p Interacts with the SH3 Domain of the Peroxisomal Membrane Protein Pex13p in an Unconventional, Non-PXXP–related Manner

2000 • 107 citations

Pex8p, an Intraperoxisomal Peroxin of Saccharomyces cerevisiae Required for Protein Transport into Peroxisomes Binds the PTS1 Receptor Pex5p

2000 • 91 citations

The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction

2000 • 90 citations

Peroxisome biogenesis: from yeast to man

1998 • 49 citations

A proposed model for the PEX5-peroxisomal targeting signal-1 recognition complex

2000 • 37 citations

Tetratricopeptide repeat domain of Yarrowia lipolytica Pex5p is essential for recognition of the type 1 peroxisomal targeting signal but does not confer full biological activity on Pex5p

2000 • 18 citations

Transport of Proteins and Metabolites across the Impermeable Membrane of Peroxisomes

1995 • 17 citations