Protein Phosphatase 5 Is a Major Component of Glucocorticoid Receptor·hsp90 Complexes with Properties of an FK506-binding Immunophilin

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

1991 • 641 citations

Tetratrico peptide repeat interactions: to TPR or not to TPR?

1995 • 624 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis

1990 • 507 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Peptidylproline cis‐trans‐isomerases: immunophilins

1993 • 349 citations

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1992 • 307 citations

Prolyl Isomerase: Enzymatic Catalysis of Slow Protein-Folding Reactions

1993 • 307 citations

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

1992 • 276 citations

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.

1993 • 266 citations

A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.

1994 • 261 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes.

1992 • 252 citations

A Cyclophilin Function in Hsp90-Dependent Signal Transduction

1996 • 233 citations

A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23.

1994 • 231 citations

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins.

1990 • 229 citations

The Tetratricopeptide Repeat Domain of Protein Phosphatase 5 Mediates Binding to Glucocorticoid Receptor Heterocomplexes and Acts as a Dominant Negative Mutant

1996 • 224 citations

Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp70.

1996 • 212 citations

The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins

1990 • 210 citations

Identification of phosphorylated sites in the mouse glucocorticoid receptor.

1991 • 208 citations

Molecular Cloning of Human FKBP51 and Comparisons of Immunophilin Interactions with Hsp90 and Progesterone Receptor

1997 • 197 citations

The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59)

1993 • 192 citations

Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

1990 • 187 citations

P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

1992 • 181 citations

Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000.

1991 • 177 citations

Cyclophilin 40 (CyP-40), Mapping of Its hsp90 Binding Domain and Evidence That FKBP52 Competes with CyP-40 for hsp90 Binding

1996 • 174 citations

The Cyclosporin A-binding Immunophilin CyP-40 and the FK506-binding Immunophilin hsp56 Bind to a Common Site on hsp90 and Exist in Independent Cytosolic Heterocomplexes with the Untransformed Glucocorticoid Receptor

1995 • 172 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90.

1994 • 169 citations

An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein.

1992 • 168 citations

A Model of Protein Targeting Mediated by Immunophilins and Other Proteins That Bind to hsp90 via Tetratricopeptide Repeat Domains

1996 • 163 citations

The Carboxy-Terminal Region of Mammalian HSP90 Is Required for Its Dimerization and Function In Vivo

1994 • 161 citations

Reconstitution of the Steroid Receptor·hsp90 Heterocomplex Assembly System of Rabbit Reticulocyte Lysate

1996 • 160 citations

Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1.

1992 • 160 citations

The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain.

1994 • 155 citations

Protein Phosphatase Types 1 and/or 2A Regulate Nucleocytoplasmic Shuttling of Glucocorticoid Receptors

1991 • 153 citations

Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor.

1994 • 149 citations

Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain.

1994 • 132 citations

Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus.

1995 • 131 citations

Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization

1993 • 128 citations

Two FKBP-related proteins are associated with progesterone receptor complexes.

1993 • 106 citations

Cyclosporin A potentiates the dexamethasone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells: a possible role for different heat shock protein-binding immunophilins in glucocorticosteroid receptor-mediated gene expression.

1995 • 96 citations

Protein components of the nonactivated glucocorticoid receptor.

1991 • 83 citations

The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor.

1994 • 82 citations

Rabbit FKBP59-heat shock protein binding immunophillin (HBI) is a calmodulin binding protein

1992 • 80 citations

Binding of Immunophilins to the 90 kDa Heat Shock Protein (hsp90) via a Tetratricopeptide Repeat Domain Is a Conserved Protein Interaction in Plants

1996 • 79 citations

FK506 binding to the 56-kilodalton immunophilin (hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function

1993 • 78 citations

Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex

1994 • 78 citations

Demonstration by Confocal Microscopy that Unliganded Overexpressed Glucocorticoid Receptors are Distributed in a Nonrandom Manner throughout All Planes of the Nucleus

1991 • 72 citations

FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts.

1993 • 72 citations

The hsp56 immunophilin component of steroid receptor heterocomplexes: Could this be the elusive nuclear localization signal-binding protein?

1993 • 67 citations

Tissue distribution and cellular localization of hsp56, an FK506-binding protein. Characterization using a highly specific polyclonal antibody.

1992 • 66 citations

Identification of two isoenzymes of protein phosphatase 2C in both rabbit skeletal muscle and liver

1987 • 66 citations

Cyclophilin-40: evidence for a dimeric complex with hsp90

1995 • 65 citations

Subunit structure of the nonactivated human estrogen receptor.

1995 • 64 citations

High Level Expression of Wild Type and Variant Mouse Glucocorticoid Receptors in Chinese Hamster Ovary Cells

1990 • 61 citations

Development of a monoclonal antibody to the rabbit 8.5S uterine progestin receptor

1985 • 56 citations

Isolation of untransformed bovine estrogen receptor without molybdate stabilization

1990 • 41 citations

Heterotetrameric structure of the human progesterone receptor.

1992 • 36 citations

Glucocorticoid Receptor Structure and Leukemic Cell Responses

1995 • 21 citations