Evidence using a green fluorescent protein-glucocorticoid receptor chimera that the Ran/TC4 GTPase mediates an essential function independent of nuclear protein import

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

Distinct functions for the two importin subunits in nuclear protein import

1995 • 479 citations

Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region

1995 • 471 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus.

1994 • 418 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

1995 • 247 citations

Mechanisms of nuclear protein import

1995 • 241 citations

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form

1995 • 188 citations

Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

1993 • 183 citations

The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.

1995 • 170 citations

Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.

1995 • 168 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

1994 • 138 citations

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.

1994 • 134 citations

The C Terminus of the Nuclear RAN/TC4 GTPase Stabilizes the GDP-bound State and Mediates Interactions with RCC1, RAN-GAP, and HTF9A/RANBP1

1995 • 133 citations

RNA1 Encodes a GTPase-activating Protein Specific for Gsp1p, the Ran/TC4 Homologue of Saccharomyces cerevisiae

1995 • 129 citations

Physical properties of estrogen receptor complexes in MCF-7 human breast cancer cells. Differences with anti-estrogen and estrogen.

1982 • 125 citations

A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation

1994 • 116 citations

Diverse Effects of the Guanine Nucleotide Exchange Factor RCC1 on RNA Transport

1995 • 114 citations

The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif.

1995 • 105 citations

Nuclear binding of glucocorticoid receptors: Relations between cytosol binding, activation and the biological response

1980 • 97 citations

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

1994 • 88 citations

v-mosOncoproteins Affect the Nuclear Retention and Reutilization of Glucocorticoid Receptors

1989 • 85 citations

Effects of mutant Ran/TC4 proteins on cell cycle progression.

1994 • 77 citations

Separate Domains of the Ran GTPase Interact with Different Factors To Regulate Nuclear Protein Import and RNA Processing

1995 • 68 citations

Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis.

1995 • 65 citations

Functional expression in Escherichia coli of the mitotic regulator proteins p24ran and p45rcc1 and fluorescence measurements of their interaction

1993 • 64 citations

Ran Binding Domains Promote the Interaction of Ran with p97/β-Karyopherin, Linking the Docking and Translocation Steps of Nuclear Import

1996 • 54 citations

Muscarinic Receptors Transform NIH 3T3 Cells through a Ras-Dependent Signalling Pathway Inhibited by the Ras-GTPase-Activating Protein SH3 Domain

1994 • 26 citations

Effects of Mutant Ran/TC4 Proteins on Cell Cycle Progression

1994 • 20 citations

The mechanism of nuclear transport of natural or artificial transport substrates in digitonin-permeabilized cells

1995 • 15 citations