Oxidative damage and age-related functional declines

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A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss

2001 • 3,104 citations

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1985 • 2,999 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration

2000 • 1,987 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Decline in skeletal muscle mitochondrial function with aging in humans

2005 • 1,177 citations

Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group

1994 • 1,170 citations

Age-related changes in lymphocyte development and function

2004 • 1,164 citations

The variability of female reproductive ageing

2002 • 1,131 citations

Prevalence of Olfactory Impairment in Older Adults

2002 • 1,060 citations

Overview of caloric restriction and ageing

2005 • 1,040 citations

Calorie restriction, SIRT1 and metabolism: understanding longevity

2005 • 1,005 citations

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

1999 • 983 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration

1994 • 905 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Effects of male age on semen quality and fertility: a review of the literature

2001 • 672 citations

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

2001 • 642 citations

Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal

2002 • 588 citations

Oxidative Stress, Mitochondrial DNA Mutation, and Impairment of Antioxidant Enzymes in Aging

2002 • 583 citations

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

2003 • 573 citations

Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects

1997 • 541 citations

Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration

2003 • 537 citations

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

Invited Review: Theories of aging

2003 • 508 citations

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.

1996 • 493 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

Superoxide dismutase evolution and life span regulation

2004 • 456 citations

Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

1999 • 450 citations

Muscle tissue changes with aging

2004 • 450 citations

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

2002 • 440 citations

Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in

2005 • 438 citations

Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits

1998 • 434 citations

GENETICS OF LIFE HISTORY IN DROSOPHILA MELANOGASTER. II. EXPLORATORY SELECTION EXPERIMENTS

1981 • 414 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

Protein oxidation and proteolysis during aging and oxidative stress

1989 • 396 citations

Methionine oxidation and aging

2004 • 387 citations

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

1989 • 381 citations

Sexual desire in later life

2005 • 374 citations

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

2003 • 370 citations

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia

2001 • 368 citations

Aging: Overview

2001 • 366 citations

Endocrinology: An Integrated Approach

2001 • 342 citations

Reactive Oxygen Disrupts Mitochondria in MA-10 Tumor Leydig Cells and Inhibits Steroidogenic Acute Regulatory (StAR) Protein and Steroidogenesis

2003 • 328 citations

Carboxyethylpyrrole Protein Adducts and Autoantibodies, Biomarkers for Age-related Macular Degeneration

2003 • 326 citations

Pathologic Features of Senile Macular Degeneration

2005 • 314 citations

What Cognitive Changes can be Expected with Normal Ageing?

2001 • 312 citations

Overexpression of the small mitochondrial Hsp22 extendsDrosophilalife span and increases resistance to oxidative stress

2004 • 306 citations

Functional senescence in Drosophila melanogaster

2005 • 299 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Effect of Age and Caloric Intake on Protein Oxidation in Different Brain Regions and on Behavioral Functions of the Mouse

1996 • 290 citations

Life extension in Drosophila by feeding a drug

2002 • 289 citations

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

2000 • 288 citations

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

1987 • 280 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 • 276 citations

Potential Options for Preservation of Fertility in Women

2005 • 273 citations

Biophysical consequences of lipid peroxidation in membranes

1987 • 250 citations

Selection for life span in Drosophila melanogaster

1985 • 247 citations

Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients

2002 • 247 citations

Mitochondrial Free Radical Production and Aging in Mammals and Birds^a

1998 • 244 citations

Pathologic Features of Senile Macular Degeneratlon

1985 • 242 citations

The Effect of Visual and Hearing Impairments on Functional Status

1999 • 242 citations

Mitochondria: are they the seat of senescence?

2003 • 236 citations

The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.

1988 • 235 citations

Effects of Dietary Restriction and Antioxidants on Presbyacusis

2000 • 235 citations

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

1997 • 234 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Age-Dependent Declines in Proteasome Activity in the Heart

2002 • 231 citations

Effects of antioxidants on immune system ageing

2002 • 228 citations

Biology of Aging: Observations and Principles

1998 • 220 citations

Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle

2000 • 215 citations

Another set of responses and correlated responses to selection on age at reproduction in Drosophila melanogaster

1999 • 209 citations

RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress

2002 • 208 citations

Increase of Oxidatively Modified Protein Is Associated With a Decrease of Proteasome Activity and Content in Aging Epidermal Cells

2000 • 205 citations

Oxidative stress and mitochondrial function with aging – the effects of calorie restriction

2003 • 200 citations

Multiple-stress analysis for isolation ofDrosophilalongevity genes

2004 • 199 citations

Altered proteasome function and subunit composition in aged muscle

2003 • 197 citations

Membranes and Transport

1973 • 197 citations

Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells

2004 • 193 citations

Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging

2004 • 193 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Fibroblast cultures from healthy centenarians have an active proteasome

2000 • 192 citations

Oxidative damage increases with age in a canine model of human brain aging

2002 • 191 citations

The biology of aging : observations and principles

2006 • 189 citations

DNA oxidative damage and life expectancy in houseflies.

1994 • 188 citations

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner

2005 • 188 citations

Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster

2005 • 187 citations

Chronic antioxidant treatment improves the cognitive performance of aged rats

1995 • 186 citations

Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase

1999 • 184 citations

Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster

1990 • 180 citations

Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly

2005 • 178 citations

Age-related alterations of proteasome structure and function in aging epidermis

2000 • 177 citations

Antioxidant Enzymes in the Aging Human Retinal Pigment Epithelium

1991 • 177 citations

Selectivity of protein oxidative damage during aging in Drosophila melanogaster

2001 • 177 citations

The role of cell adhesion molecules in synaptic plasticity and memory

1999 • 172 citations

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1995 • 170 citations

Aging Specifically Impairs amnesiac-Dependent Memory in Drosophila

2003 • 166 citations

Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle

1997 • 162 citations

Membranes and Transport

1982 • 154 citations

A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

2003 • 154 citations

Molecular mechanisms of age-related hearing loss

2002 • 151 citations

Dietary Supplementation with Vitamin E Reverses the Age-related Deficit in Long Term Potentiation in Dentate Gyrus

1998 • 149 citations

The effects of gene-environment interaction on the expression of longevity

1985 • 148 citations

Age‐dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria

2002 • 142 citations

Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function?

2001 • 137 citations

The Effect of Long‐term Dietary Supplementation with Antioxidants^a

1998 • 136 citations

Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns☆

2000 • 133 citations

Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice

1999 • 131 citations

Effect of Ethoxyquin on the Longevity of C3H Mice

1971 • 129 citations

Impact of ageing on proteasome structure and function in human lymphocytes

2003 • 129 citations

Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging

2001 • 127 citations

Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy

1998 • 120 citations

Aging and protein oxidative damage

1994 • 119 citations

DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila

2004 • 119 citations

Vitamin E, aging and Leydig cell steroidogenesis

2005 • 116 citations

Oxidative stress, aging and longevity in Drosophila melanogaster

2001 • 115 citations

Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction

1998 • 115 citations

Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins

2000 • 114 citations

The demography of slow aging in male and female Drosophila mutant for the insulin‐receptor substrate homologue chico

2002 • 114 citations

Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function

1996 • 112 citations

Alteration of Rat Liver 20S Proteasome Activities by Age and Food Restriction

1996 • 112 citations

Vitamin E Supplementation Decreases Lung Virus Titers in Mice Infected with Influenza

1997 • 107 citations

Proteasome Function and Protein Oxidation in the Aged Retina

2002 • 103 citations

Age-related Decline in Ubiquitin Conjugation in Response to Oxidative Stress in the Lens

1997 • 97 citations

Differential effects of age on motor performance in two mouse strains

1981 • 95 citations

Selectivity of protein oxidative damage during aging in Drosophila melanogaster

2001 • 94 citations

Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila

1998 • 94 citations

Effect of Diet Restriction on Some Biochemical Parameters Related to Aging in Mice

1983 • 94 citations

The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells.

1993 • 93 citations

Age-dependent protein modifications and declining proteasome activity in the human lens

2004 • 93 citations

Enzymatic reactions involved in the repair of oxidized proteins

2004 • 88 citations

Stress resistance and longevity in selected lines of Drosophila melanogaster☆

1999 • 85 citations

Mitochondrial DNA Deletion Mutations and Sarcopenia

2002 • 85 citations

Dissociation between functional senescence and oxidative stress resistance in Drosophila

2002 • 82 citations

Improvement by several antioxidants of macrophage function in vitro

1998 • 81 citations

Calorie restriction delays lipid oxidative damage in Drosophila melanogaster

2005 • 81 citations

Antioxidant therapy counteracts the disturbing effects of diamide and maternal ageing on meiotic division and chromosomal segregation in mouse oocytes

1998 • 79 citations

The oxidizing agent tertiary butyl hydroperoxide induces disturbances in spindle organization, c-meiosis, and aneuploidy in mouse oocytes

1996 • 78 citations

Relationships between glycation and oxidation related fluorescences in rat collagen during aging. An in vivo and in vitro study.

1994 • 78 citations

Concurrent administration of coenzyme Q10 and α-tocopherol improves learning in aged mice

2004 • 78 citations

Olfactory Capacities in Aging and Alzheimer's Diseasea

1991 • 77 citations

The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS‐1), are downregulated during replicative senescence of human WI‐38 fibroblasts

2004 • 76 citations

Effects of long-term administration of melatonin and a putative antagonist on the ageing rat

1995 • 74 citations

Low glutathione reductase and peroxidase activity in age-related macular degeneration.

1994 • 71 citations

Plasma malondialdehyde and nitric oxide levels in age related macular degeneration

2001 • 71 citations

Genetic alteration of normal aging processes is responsible for extended longevity in Drosophila

1990 • 70 citations

Effect of SOD1 overexpression on age- and noise-related hearing loss

2003 • 70 citations

Insights into age-related locomotor declines from studies of insects

2004 • 63 citations

Localization of atrophy-prone areas in the aging mouse brain: Comparison between the brain atrophy model SAM-P/10 and the normal control SAM-R/1

1994 • 58 citations

Delayed behavioural aging and altered mortality in Drosophilaβ integrin mutants

2003 • 55 citations

The Amount of Thiolic Antioxidant Ingestion Needed to Improve Several Immune Functions is Higher in Aged than in Adult Mice

2002 • 53 citations

The Effects of Long-Term Vitamin E Treatment on Gene Expression and Oxidative Stress Damage in the Aging Brown Norway Rat Epididymis1

2004 • 53 citations

The Oxidative Modification of Lens Proteins

1988 • 52 citations

Changes in superoxide dismutase activity and copper during development and ageing in the fruit fly Drosophila melanogaster

1980 • 50 citations

Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage☆

2000 • 50 citations

Ageing is associated in females with a decline in the content and activity of the b-c1 complex in skeletal muscle mitochondria

1996 • 49 citations

Endocrine Alterations and Signaling Changes Associated with Declining Ovarian Function and Advanced Biological Aging in Follicle-Stimulating Hormone Receptor Haploinsufficient Mice1

2002 • 49 citations

Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats

1995 • 48 citations

Serum oxidative and antioxidant parameters in a group of Italian patients with age-related maculopathy

2002 • 45 citations

Effect of temperature and different sex ratios on physical activity and life span in the adult housefly, musca domestica

1981 • 45 citations

Changes in Antioxidant Enzyme Activity and Malondialdehyde Level in Patients with Age-Related Macular Degeneration

2004 • 44 citations

Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster

2004 • 41 citations

Protein restriction (PR) and caloric restriction (CR) compared: effects on DNA damage, carcinogenesis, and oxidative damage

1993 • 39 citations

Vitamin E and Respiratory Infection in the Elderly

2004 • 38 citations

The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet

1996 • 37 citations

Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1)

2000 • 37 citations

Appearance of 1∼2 Mbp Giant DNA Fragments as an Early Common Response Leading to Cell Death Induced by Various Substances That Cause Oxidative Stress

1997 • 37 citations

Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice.

2002 • 34 citations

In the Aging Housefly Aconitase Is the Only Citric Acid Cycle Enzyme to Decline Significantly

2005 • 31 citations

Suppression of steroidogenesis and activator protein-1 transcription factor activity in rat adrenals by vitamin E deficiency–induced chronic oxidative stress

2004 • 29 citations

Mitochondrial oxidative phosphorylation system assembly in man: recent achievements

2001 • 29 citations

Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice

2003 • 28 citations

Special issue on dietary restriction: Dietary restriction, longevity and ageing—the current state of our knowledge and ignorance

2005 • 25 citations

Memory Decline of Aging Reduced by Extracellular Superoxide Dismutase Overexpression

2005 • 24 citations

Changes in Superoxide Dismutase and Catalase in Aging Heat-ShockedDrosophila

1992 • 23 citations

THE ROLE OF COENZYME Q-10 IN AGING: A FOLLOW-UP STUDY ON LIFELONG ORAL SUPPLEMENTATION Q-10 IN RATS

1995 • 16 citations

Atherogenic change in the thoracic aorta of the senescence-accelerated mouse

1995 • 9 citations

Increased Longevity, Reduced Fecundity, and Delayed Development in Fruitfly (Zaprionus paravittiger) Fed on Butylated Hydroxy Anisole

1997 • 8 citations

Endocrinology: An Integrated Approach

2002 • 2 citations