Reactive Oxygen Disrupts Mitochondria in MA-10 Tumor Leydig Cells and Inhibits Steroidogenic Acute Regulatory (StAR) Protein and Steroidogenesis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives

1999 • 1,156 citations

The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR).

1994 • 1,140 citations

Mitochondria, oxygen free radicals, disease and ageing

2000 • 1,054 citations

pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin

1988 • 1,039 citations

StAR Protein and the Regulation of Steroid Hormone Biosynthesis

2001 • 869 citations

Mitochondrial Dysfunction in Cardiac Disease: Ischemia–Reperfusion, Aging, and Heart Failure

2001 • 687 citations

Role of mitochondria in oxidative stress and ageing

1998 • 649 citations

Reactive oxygen species and antioxidants in inflammatory diseases

1997 • 624 citations

Characterization of Several Clonal Lines of Cultured Ley dig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses*

1981 • 596 citations

Acute Testicular Ischemia Results in Germ Cell-Specific Apoptosis in the Rat1

1997 • 352 citations

Reactive oxygen and mechanisms of inflammatory liver injury

2000 • 348 citations

Rapid regulation of steroidogenesis by mitochondrial protein import

2002 • 345 citations

Hormonal and developmental regulation of the steroidogenic acute regulatory protein.

1995 • 296 citations

Oxidative stress and the ovary*1

2001 • 289 citations

The leydig cell

1996 • 266 citations

Regulation of Leydig Cell Steroidogenic Function During Aging1

2000 • 261 citations

Quantitation of mitochondrial alterations associated with apoptosis

2002 • 257 citations

Reactive Oxygen Species and Protein Oxidation in Aging: A Look Back, A Look Ahead

2002 • 249 citations

Mitochondrial Processing of Newly Synthesized Steroidogenic Acute Regulatory Protein (StAR), but Not Total StAR, Mediates Cholesterol Transfer to Cytochrome P450 Side Chain Cleavage Enzyme in Adrenal Cells

2001 • 212 citations

The Mechanism of Action of Steroidogenic Acute Regulatory Protein (StAR)

1998 • 193 citations

Steroidogenic acute regulatory protein (StAR) and the intramitochondrial translocation of cholesterol

2000 • 182 citations

Role of cytokines in testicular function

1999 • 171 citations

Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression.

1992 • 157 citations

Reactive oxygen species and biological aging: a mechanistic approach

1999 • 154 citations

Steroidogenic Acute Regulatory Protein

2001 • 144 citations

Age-related increase in mitochondrial superoxide generation in the testosterone-producing cells of Brown Norway rat testes: relationship to reduced steroidogenic function?

2001 • 137 citations

Hormonal Regulation of Cytochrome P450 Enzymes, Cholesterol Side-Chain Cleavage and 17α-Hydroxylase/C17 – 20 Lyase in Leydig Cells1

1990 • 134 citations

The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis.

1993 • 129 citations

Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein.

1995 • 127 citations

Effect of Truncated Forms of the Steroidogenic Acute Regulatory Protein on Intramitochondrial Cholesterol Transfer*

1998 • 127 citations

Impaired Detoxification of Reactive Oxygen and Consequent Oxidative Stress in Experimentally Cryptorchid Rat Testis1

1992 • 118 citations

Evidence That Hydrogen Peroxide Blocks Hormone- Sensitive Cholesterol Transport into Mitochondria of Rat Luteal Cells*

1991 • 116 citations

Oxidative Stress and the Ovary

2001 • 111 citations

Testicular Steroidogenesis in the Aging Brown Norway Rat

1993 • 99 citations

Oxygen-mediated damage of microsomal cytochrome P-450 enzymes in cultured leydig cells. Role in steroidogenic desensitization.

1984 • 98 citations

Steroid product-induced, oxygen-mediated damage of microsomal cytochrome P-450 enzymes in Leydig cell cultures. Relationship to desensitization.

1985 • 95 citations

The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells.

1993 • 93 citations

Antigonadotropic and Antisteroidogenic Actions of Peroxide in Rat Granulosa Cells*

1990 • 83 citations

Noncoordinate Regulation ofde NovoSynthesis of Cytochrome P-450 Cholesterol Side-Chain Cleavage and Cytochrome P-450 17α-Hydroxylase/C_17-20Lyase in Mouse Leydig Cell Cultures: Relation to Steroid Production

1987 • 82 citations

Diametric Effects of Bacterial Endotoxin Lipopolysaccharide on Adrenal and Leydig Cell Steroidogenic Acute Regulatory Protein

2000 • 78 citations

Calcium stimulates steroidogenesis in permeabilized bovine adrenal cortical cells.

1988 • 76 citations

Abdominal Position of the Rat Testis is Associated with High Level of Lipid Peroxidation1

1995 • 71 citations

Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic Acute Regulatory (StAR) proteinProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

1999 • 60 citations

Dietary antioxidants and assessment of oxidative stress

2000 • 55 citations

The involvement of oxygen radicals in microbicidal mechanisms of leukocytes and macrophages

1991 • 52 citations

Bactericidal Activity of Testicular Macrophages1

1988 • 51 citations

The role of cytokines in the regulation of Leydig cell P450c17 gene expression

1992 • 51 citations

Possible role for mitochondrial calcium in angiotensin II- and potassium-stimulated steroidogenesis in bovine adrenal glomerulosa cells.

1996 • 51 citations

The site of action of Ca2+ in the activation of steroidogenesis: studies in Ca2+-clamped bovine adrenal zona-glomerulosa cells

1995 • 48 citations

Cu/Zn Superoxide Dismutase, Catalase and Glutathione Peroxidase mRNA Expression in the Rat Testis After Surgical Cryptorchidism and Efferent Duct Ligation

1997 • 43 citations

ATP and A mitochondrial electrochemical gradient are required for functional activity of the steroidogenic acute regulatory (star) protein in isolated mitochondria

1996 • 42 citations

Physiological and pathological effects of steroids on the function of the adrenal cortex

1987 • 33 citations

Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis

2000 • 20 citations

Sources and sites of action of calcium in the regulation of aldosterone biosynthesis

1996 • 18 citations

Regulation of mineralocorticoid biosynthesis by calcium and the StAR protein

1998 • 15 citations

Microsomal Cytochrome P‐450 Enzyme Damage in Cultured Leydig Cells: Relation to Steroidogenic Desensitization ^a

1984 • 11 citations

Regulation of Mitochondrial and Microsomal Cytochrome P-450 Enzymes in Leydig Cells

1987 • 3 citations