The Effects of Long-Term Vitamin E Treatment on Gene Expression and Oxidative Stress Damage in the Aging Brown Norway Rat Epididymis1

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Vitamin E: function and metabolism

1999 • 1,547 citations

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

2003 • 1,119 citations

Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations

2000 • 880 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Antioxidant Vitamin Intake and Coronary Mortality in a Longitudinal Population Study

1994 • 648 citations

Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction

1997 • 578 citations

Lipid peroxidation in aging brain and Alzheimer’s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 440 citations

Antioxidants and oxidants regulated signal transduction pathways

2002 • 437 citations

Incidence of Cancer and Mortality Following α-Tocopherol and β-Carotene Supplementation

2003 • 423 citations

A Randomised Controlled Trial of Vitamin E in Patients with Coronary Disease: The Cambridge Heart Antioxidant Study (CHAOS)

1996 • 353 citations

The Epididymis: From Molecules to Clinical Practice

2002 • 300 citations

Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)

2002 • 299 citations

Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease

1985 • 262 citations

α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state

1998 • 259 citations

Protein kinase C and its substrates

1996 • 236 citations

Vitamin E activates gene expression via the pregnane X receptor

2002 • 226 citations

Regulation of cell signalling by vitamin E

2002 • 215 citations

Gene Expression in the Epididymis

1999 • 144 citations

Dynamic Changes in Gene Expression along the Rat Epididymis1

2001 • 142 citations

Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes

1999 • 134 citations

Oxidative Stress and Life Span Determination in the Nematode Caenorhabditis elegans

2002 • 123 citations

Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials.

2002 • 110 citations

The 80th Anniversary of Vitamin E: Beyond Its Antioxidant Properties

2002 • 107 citations

Segment-Specific Morphological Changes in Aging Brown Norway Rat Epididymis1

1998 • 101 citations

Testicular Steroidogenesis in the Aging Brown Norway Rat

1993 • 99 citations

The Effect of Aging on the Seminiferous Epithelium of the Brown Norway Rat

1993 • 85 citations

Gene Expression and Epididymal Function

2002 • 76 citations

Sperm Structural and Motility Changes During Aging in the Brown Norway Rat

2001 • 73 citations

Effects of vitamin E and carotenoid status on oxidative stress in health and disease. Evidence obtained from human intervention studies

2003 • 71 citations

Gene Expression in the Aging Brown Norway Rat Epididymis

1995 • 35 citations

The Effects of Aging on the Expression of Glutathione S‐Transferases in the Testis and Epididymis of the Brown Norway Rat

1998 • 35 citations

Changes in gene expression during aging in the Brown Norway rat epididymis

2002 • 35 citations

Differential inhibition by α- and β-tocopherol of human erythroleukemia cell adhesion: role of integrins

2001 • 35 citations

Evidence for oxidative damage in a murine leukemia virus-induced neurodegeneration

2000 • 22 citations

Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles

2001 • 20 citations

High Pressure Liquid Chromatographic Determination of Vitamins A and E in Cereal Products

1979 • 17 citations