Enzymatic reactions involved in the repair of oxidized proteins

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Protein Oxidation in Aging, Disease, and Oxidative Stress

1997 • 3,299 citations

Biochemistry and pathology of radical-mediated protein oxidation

1997 • 1,675 citations

Methionine residues as endogenous antioxidants in proteins

1996 • 1,005 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

Degradation of oxidized proteins by the 20S proteasome

2001 • 846 citations

Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD

2004 • 702 citations

Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals

2001 • 642 citations

Protein Sulfenic Acids in Redox Signaling

2004 • 569 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

Antioxidant Function of Thioredoxin and Glutaredoxin Systems

2000 • 491 citations

High-quality life extension by the enzyme peptide methionine sulfoxide reductase

2002 • 440 citations

Oxidation of Methionine in Proteins: Roles in Antioxidant Defense and Cellular Regulation

2000 • 364 citations

Repair of Oxidized Proteins

2001 • 339 citations

Overexpression of Human Thioredoxin in Transgenic Mice Controls Oxidative Stress and Life Span

2002 • 292 citations

Escherichia coli peptide methionine sulfoxide reductase gene: regulation of expression and role in protecting against oxidative damage

1995 • 288 citations

Methionine Sulfoxide Reduction in Mammals: Characterization of Methionine-R-Sulfoxide Reductases

2003 • 285 citations

Oxidation of Methionine in Proteins: Roles in Antioxidant Defense and Cellular Regulation

2000 • 284 citations

Overexpression of peptide-methionine sulfoxide reductase inSaccharomyces cerevisiaeand human T cells provides them with high resistance to oxidative stress

1998 • 268 citations

Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase

2002 • 261 citations

Decrease in Peptide Methionine Sulfoxide Reductase in Alzheimer's Disease Brain

1999 • 251 citations

A Sulfenic Acid Enzyme Intermediate Is Involved in the Catalytic Mechanism of Peptide Methionine Sulfoxide Reductase fromEscherichia coli

2000 • 187 citations

Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

2003 • 186 citations

Identification and Characterization of a Putative Active Site for Peptide Methionine Sulfoxide Reductase (MsrA) and Its Substrate Stereospecificity

2000 • 185 citations

The mirrored methionine sulfoxide reductases of Neisseria gonorrhoeae pilB

2002 • 171 citations

Protein Degradation by the Proteasome and Its Implications in Aging

2000 • 168 citations

Thiol–disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase

2000 • 164 citations

Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation

2004 • 159 citations

Regeneration of Peroxiredoxins during Recovery after Oxidative Stress

2003 • 158 citations

Reaction Mechanism, Evolutionary Analysis, and Role of Zinc in Drosophila Methionine-R-sulfoxide Reductase

2002 • 158 citations

Purification and Characterization of Methionine Sulfoxide Reductases from Mouse and Staphylococcus aureus and Their Substrate Stereospecificity

2002 • 152 citations

Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats

2000 • 141 citations

Structure and Mechanism of Peptide Methionine Sulfoxide Reductase, an “Anti-Oxidation” Enzyme^,

2000 • 141 citations

Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging

2001 • 127 citations

Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress

2003 • 122 citations

Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme‐involved in the repair of oxidized proteins

2002 • 116 citations

Removal of Oxidatively Damaged Proteins from Lens Cells by the Ubiquitin-Proteasome Pathway

2001 • 114 citations

Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells

2003 • 109 citations

Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues

2003 • 108 citations

Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)

1999 • 105 citations

Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process

2003 • 98 citations

Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

1996 • 77 citations

The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS‐1), are downregulated during replicative senescence of human WI‐38 fibroblasts

2004 • 76 citations

Activity, tissue distribution and site‐directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1

2002 • 70 citations

Structure ofMycobacterium tuberculosisMethionine Sulfoxide Reductase A in Complex with Protein-Bound Methionine

2003 • 70 citations

Reverse genetic approaches in plants and yeast suggest a role for novel, evolutionarily conserved, selenoprotein-related genes in oxidative stress defense

2002 • 56 citations

Thiol-Disulfide Exchange Systems in the Liver of Aging Fischer 344 Rats

1998 • 13 citations

Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase fromEscherichia coli

2000 • 6 citations