Age-dependent protein modifications and declining proteasome activity in the human lens
Data up to Jan 2025
Total Citations Per Year
Abstract
References (34)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
1970 • 253,849 citations
STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES
1996 • 2,408 citations
Degradation of oxidized proteins by the 20S proteasome
2001 • 846 citations
Protein Oxidation in Aging and Age‐Related Diseases
2001 • 656 citations
Comparative resistance of the 20S and 26S proteasome to oxidative stress
1998 • 442 citations
Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.
1994 • 311 citations
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
2000 • 302 citations
Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex
2000 • 301 citations
Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein
1997 • 264 citations
Age-Dependent Declines in Proteasome Activity in the Heart
2002 • 231 citations
A STUDY OF THE PHOTODYNAMIC EFFICIENCIES OF SOME EYE LENS CONSTITUENTS
1991 • 225 citations
Age-Related Decline of Rat Liver Multicatalytic Proteinase Activity and Protection from Oxidative Inactivation by Heat-Shock Protein 90
1996 • 214 citations
Age-related alterations of proteasome structure and function in aging epidermis
2000 • 177 citations
Proteasome Inhibition in Glyoxal-treated Fibroblasts and Resistance of Glycated Glucose-6-phosphate Dehydrogenase to 20 S Proteasome Degradation in Vitro
2001 • 124 citations
Removal of Oxidatively Damaged Proteins from Lens Cells by the Ubiquitin-Proteasome Pathway
2001 • 114 citations
Ascorbic acid-induced crosslinking of lens proteins: evidence supporting a Maillard reaction
1988 • 113 citations
Proteasome Function and Protein Oxidation in the Aged Retina
2002 • 103 citations
Protein synthesis in the core of calf lens
1968 • 103 citations
The precipitation and cross-linking of lens crystallins by ascorbic acid
1988 • 93 citations
Age-Dependent Association of Isolated Bovine Lens Multicatalytic Proteinase Complex (Proteasome) with Heat-Shock Protein 90, an Endogenous Inhibitor
1995 • 92 citations
The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
2001 • 85 citations
Caretaker or undertaker? The role of the proteasome in aging
2001 • 83 citations
Proteasomes in apoptosis: villains or guardians?
1999 • 76 citations
Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.
1999 • 70 citations
Glutathione inhibits the glycation and crosslinking of lens proteins by ascorbic acid
1988 • 69 citations
Function of the ubiquitin proteolytic pathway in the eye
2003 • 55 citations
Proteasome Function and Protein Oxidation in the Aged Retina
2002 • 53 citations
Lens fibers have a fully functional ubiquitin-proteasome pathway
2003 • 49 citations
Ascorbic Acid Glycation: the Reactions of l-Threose in Lens Tissue
1994 • 43 citations
Relationship between Autofluorescence and Advanced Glycation End Products in Diabetic Lenses
1999 • 37 citations
Proteasome activity in human lens nuclei and correlation with age, gender and severity of cataract
2003 • 31 citations
Differential Inhibition of Three Peptidase Activities of the Proteasome in Human Lens Epithelium by Heat and Oxidation
1999 • 30 citations
Coloration of human lens protein
1975 • 26 citations
Targeted disruption of specific steps of the ubiquitin–proteasome pathway by oxidation in lens epithelial cells
2003 • 22 citations